Characteristics and outcomes of young patients with laryngeal cancer: National <scp>hospital‐based</scp> retrospective cohort analysis

Yang, Alex; Tanamal, Priscilla; Tibbetts, Kathleen M.; Sumer, Baran D.; Blackwell, James-Michael; Schostag, Kelly; Sher, David J.; Day, Andrew T.

doi:10.1002/hed.27120

Cited by 1 publication

(2 citation statements)

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“…Human papillomavirus (HPV) infections cause highly morbid laryngeal diseases, accounting for 95% of recurrent respiratory papillomatosis (RRP) cases 1 and up to 25% of laryngeal squamous cell carcinomas (SCCs). 2,3 RRP is caused by low-risk HPVs, specifically types 6 and 11. 4 High-risk HPVs that cause cancer include types 16, 18, and 31, but genotypes in laryngeal SCC are not routinely reported.…”

Section: Introductionmentioning

confidence: 99%

“…9,[11][12][13] Preclinical models of HPV-positive laryngeal SCC have not been widely reported because laryngeal SCC is associated primarily with smoking rather than HPV infection. [14][15][16] However, HPV positivity in laryngeal SCC is higher in younger patients than in older patients, 3 suggesting that the role of HPV in laryngeal cancer is growing.…”

Section: Introductionmentioning

confidence: 99%

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Preclinical Models of Laryngeal Papillomavirus Infection: A Scoping Review

et al. 2023

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ObjectiveLaryngeal human papillomavirus (HPV) infection causes recurrent respiratory papillomatosis (RRP) and accounts for up to 25% of laryngeal cancers. Lack of satisfactory preclinical models is one reason that treatments for these diseases are limited. We sought to assess the literature describing preclinical models of laryngeal papillomavirus infection.Data SourcesPubMed, Web of Science, and Scopus were searched from the inception of database through October 2022.Review MethodsStudies searched were screened by two investigators. Eligible studies were peer‐reviewed, published in English, presented original data, and described attempted models of laryngeal papillomavirus infection. Data examined included type of papillomavirus, infection model, and results including success rate, disease phenotype, and viral retention.ResultsAfter screening 440 citations and 138 full‐text studies, 77 studies published between 1923 and 2022 were included. Models used low‐risk HPV or RRP (n = 51 studies), high‐risk HPV or laryngeal cancer (n = 16), both low‐ and high‐risk HPV (n = 1), and animal papillomaviruses (n = 9). For RRP, 2D and 3D cell culture models and xenografts retained disease phenotypes and HPV DNA in the short term. Two laryngeal cancer cell lines were consistently HPV‐positive in multiple studies. Animal laryngeal infections with animal papillomaviruses resulted in disease and long‐term retention of viral DNA.ConclusionsLaryngeal papillomavirus infection models have been researched for 100 years and primarily involve low‐risk HPV. Most models lose viral DNA after a short duration. Future work is needed to model persistent and recurrent diseases, consistent with RRP and HPV‐positive laryngeal cancer.Level of EvidenceN/A Laryngoscope, 2023

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