Characteristics and Outcomes of Patients With Myocarditis Listed for Heart Transplantation

ElAmm, Chantal; Al‐Kindi, Sadeer G.; Oliveira, Guilherme H.

doi:10.1161/circheartfailure.116.003259

Cited by 21 publications

(18 citation statements)

References 20 publications

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“…Long-term implantable left ventricle assist devices (LVADs) are rarely used to provide adequate circulation for a more extended time period to allow the resolution of myocarditis and bridge a patient from emergent temporary MCS to HTx, which is the final option for treating critically ill patients affected by myocarditis. HTx survival is comparable to that of patients with other types of HF as shown in a recent series, although higher rates of relapses have been demonstrated, especially in patients with GCM undergoing HTx ( 36 , 37 ). Once patients with FM recover from cardiogenic shock, pharmacological treatment for HF, including beta-blockers, diuretics, angiotensin-converting enzyme inhibitors or angiotensin-II receptor blockers, should be initiated according to current consensus ( 38 ).…”

Section: Introductionsupporting

confidence: 55%

Fulminant myocarditis: Characteristics, treatment, and outcomes

Veronese¹

2018

Anatol J Cardiol

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Myocarditis is an inflammatory disease of the myocardium with a broad spectrum of clinical presentations, ranging from mild symptoms to severe heart failure. The course of patients with myocarditis is heterogeneous, varying from partial or full clinical recovery in few days to advanced low cardiac output syndrome requiring mechanical circulatory support or heart transplantation. Fulminant myocarditis (FM) is a peculiar clinical condition and is an acute form of myocarditis, whose main characteristic is a rapidly progressive clinical course with the need for hemodynamic support. Despite the common medical belief of the past decades, recent comprehensive data, including a recent registry that compared FM with acute non-FM, highlighted that FM has a poor inhospital outcome, often requires advanced hemodynamic support, and may result in residual left ventricular dysfunction in survivors. This review aimed to provide an updated practical definition of FM, including essentials in the diagnosis and management of the disease. Finally, the outcome of FM was critically revised according to the current published registries focusing on the topic.

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Section: Introductionsupporting

confidence: 55%

Fulminant myocarditis: Characteristics, treatment, and outcomes

Veronese¹

2018

Anatol J Cardiol

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“…The proportion of female COVID‐19 patients with myocarditis was similar to that reported by Ammirati et al (34.1% vs. 38.9%) 13 and comparable to myocarditis caused by other pathogens than SARS‐CoV‐2 15,36–38 …”

Section: Discussionsupporting

confidence: 87%

“…The proportion of female COVID-19 patients with myocarditis was similar to that reported by Ammirati et al (34.1% vs. 38.9%) 13 and comparable to myocarditis caused by other pathogens than SARS-CoV-2. 15,[36][37][38] Our study demonstrated that the highest absolute numbers of myocarditis cases were seen during spring (March/April) and in winter (November/December), along with the highest numbers of hospitalized COVID-19 patients 5,18 and thus, following the seasonal variations of viral infections. 18,27 In this context, the highest relative numbers of myocarditis, in turn, were identified in the summer, suggesting that in summer was the risk of developing myocarditis at its maximum.…”

Section: Resultsmentioning

confidence: 57%

Incidence and risk factors of myocarditis in hospitalized patients with COVID‐19

Keller

Sagoschen

Konstantinides

et al. 2023

Journal of Medical Virology

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Myocarditis as cardiac involvement in coronavirus disease 2019 (COVID-19)infection is well known. Real-world data about incidence in hospitalized COVID-19patients and risk factors for myocarditis in COVID-19-patients are sparse. We used the German nationwide inpatient sample to analyze all hospitalized patients with confirmed COVID-19-diagnosis in Germany in 2020 and stratified them for myocarditis. Overall, 176 137 hospitalizations (52.3% males, 53.6% aged ≥70 years) with confirmed COVID-19-infection were coded in Germany in 2020 and among them, 226 (0.01%) had myocarditis (incidence: 1.28 per 1000 hospitalization-cases).Absolute numbers of myocarditis increased, while relative numbers decreased with age. COVID-19-patients with myocarditis were younger (64.0 [IQR: 43.0/78.0] vs. 71.0 [56.0/82.0], p < 0.001). In-hospital case-fatality was 1.3-fold higher in COVID-19-patients with than without myocarditis (24.3% vs. 18.9%, p = 0.012).

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“…The severity and prognosis of myocarditis varies greatly, from asymptomatic episodes with spontaneous improvement to severe heart failure or other cardiac complications. In the acute phase systolic dysfunction, ventricular arrhythmias and sudden deaths may ensue and in the chronic phase it can result in heart failure, which may require advanced treatment such as left ventricular assist devices and transplantation in severe cases [10].…”

Section: Discussionmentioning

confidence: 99%

A case report of acute Leriche syndrome: aortoiliac occlusive disease due to embolization from left ventricular thrombus caused by myocarditis

Mohamed

Mattsson

Magnusson

2021

BMC Cardiovasc Disord

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Background Leriche syndrome is the triad of symptoms consisting of claudication, erectile dysfunction, and absence of femoral pulses. Inflammatory disease of the heart muscle, myocarditis, may occur because of immune system activation, drug exposure or infections. Case presentation A 31-year-old man with no previous medical history presented to the emergency department with acute back pain that had started suddenly during weightlifting, which was initially misdiagnosed as spinal disc herniation. The patient returned four hours later and a thoracoabdominal computed tomography showed a large thrombus in the aortoiliac region creating a total occlusion. Vascular surgery with embolectomy was immediately performed. Further investigation with echocardiography revealed deteriorated systolic dysfunction with marked hypokinesia and two large thrombi in the left ventricle. Cardiac magnetic resonance imaging showed late contrast enhancement of the inferolateral and septal regions, which indicated a recent myocarditis. Conclusion Myocarditis can result in multiple embolization with diverse organ manifestation including total occlusion of the aortoiliac arteries, which required urgent embolectomy.

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Characteristics and Outcomes of Patients With Myocarditis Listed for Heart Transplantation

Cited by 21 publications

References 20 publications

Fulminant myocarditis: Characteristics, treatment, and outcomes

Fulminant myocarditis: Characteristics, treatment, and outcomes

Incidence and risk factors of myocarditis in hospitalized patients with COVID‐19

A case report of acute Leriche syndrome: aortoiliac occlusive disease due to embolization from left ventricular thrombus caused by myocarditis

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