Characteristics and outcomes of patients with community-acquired and
            hospital-acquired sepsis

Westphal, Glauco Adrieno; Pereira, Aline Braz; Fachin, Silvia Maria; Barreto, Alessandra Costa; Bornschein, Ana Carolina Gern Junqueira; Filho, Milton Caldeira; Köenig, Álvaro

doi:10.5935/0103-507x.20190013

Cited by 41 publications

(47 citation statements)

References 28 publications

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“…In our study, the infection sites of CASS were primarily the respiratory tract, central nervous system, and digestive tract. The infection sites of CASS varied widely among studies; however, the main site was the respiratory tract, which is in line with the ndings of our study [19].…”

Section: Discussionsupporting

confidence: 91%

Comparison of Hospital- and Community-Acquired Septic Shock in Children: A Single-Center, Cohort, Retrospective Study

Fan

Fang

et al. 2021

Preprint

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Background To explore differences between hospital- (HASS) and community-acquired septic shock (CASS) in patient characteristics, pathogens, complications, outcomes, and risk factors in pediatric intensive care unit (PICU) children. Methods This retrospective study enrolled septic shock children from January 1, 2016, to December 31, 2019. The patients were followed up until 28 days after shock or death and were divided into HASS and CASS groups. After comparison, logistic regression analyses were used to identify risk factors for mortality. Results A total of 298 children were enrolled. 65.9% of HASS patients (N = 91) had hematological/tumor diseases and were mainly bloodstream infections of Gram-negative bacteria (47.3%). 67.7% of CASS (N = 207) had no obvious underlying disease and were mostly infected with Gram-positive bacteria (30.9%) of the respiratory or central nervous system. 28-day mortality was 62.6% and 32.7% in HASS and CASS groups, respectively (p < 0.001). The factor associated with 28-day mortality of HASS and CASS was MODS (OR:11.524; 95% CI: 2.140-62.051) and needed invasive mechanical ventilation therapy (OR:6.884; 95% CI: 1.499–31.624), respectively. Conclusions The underlying diseases, pathogens, complications, prognosis and mortality varied widely. 28-day mortality is associated with MODS and need for invasive mechanical ventilation therapy in HASS and CASS patients.

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Section: Discussionsupporting

confidence: 91%

Comparison of Hospital- and Community-Acquired Septic Shock in Children: A Single-Center, Cohort, Retrospective Study

Fan

Fang

et al. 2021

Preprint

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“…According to the SPREAD and PROGRESS studies, the mortality rate of patients with sepsis in Brazil is 55.7% and 57.4%, respectively (4) . These percentages are significantly higher than the 45% and 38.2% reported for developing and developed countries, respectively (3) . However, the SPREAD study authors concluded that Brazilian Journal of Development, Curitiba, v.7, n.2, p. 17924-17935 feb. 2021 inadequate treatment, delayed administration of antibiotics, high disease severity, and hospital infection are directly related to patient mortality (4) .…”

Section: Introductioncontrasting

confidence: 58%

Risk Factors Associated With Increased Mortality in Septic Patients Admitted to the Intensive Care Unit/ Fatores De Risco Associados Ao Aumento Da Mortalidade Em Pacientes Sépticos Admitidos Na Unidade De Terapia Intensiva

Rocha

Nascimento

Freitas

et al. 2021

BJD

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Sepsis is a potentially fatal clinical syndrome characterized by an abnormal response to infection associated with organic dysfunction. It is a relevant cause of admission to intensive care units (ICUs) and related to increased morbidity and mortality rates. This study aimed to evaluate the epidemiological profile of adult ICU patients of Lauro Wanderley University Hospital (HULW) in the municipality of João Pessoa (PB) to determine the risk factors associated with increased mortality in patients with sepsis. This retrospective and observational methodological study evaluated the epidemiological profile and characteristics of patients with sepsis, aiming to analyze the risk factors related to increased mortality. The mortality risk analysis was performed in two parts. The first was made from Pearson's chi-square test to determine the association between categorical

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“…Hospital-acquired sepsis was more likely to be associated with lung infections and less likely to be associated with abdominal infections than community-acquired sepsis. Recent studies showed that patients with hospital-acquired sepsis had an elevated mortality ( 37 – 39 ). However, we did not find that hospital-acquired sepsis was associated with significantly increased mortality, which may be related to our failure to include ICU-acquired sepsis.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence, Risk Factors, and Outcomes of Sepsis in Critically Ill Patients in China: A Multicenter Prospective Cohort Study

et al. 2020

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Background: Sepsis is a main cause of morbidity and mortality in critically ill patients. The epidemiology of sepsis in high-income countries is well-known, but information on sepsis in middle- or low-income countries is still deficient, especially in China. The purpose of this study was to explore the prevalence, characteristics, risk factors, treatment, and outcomes of sepsis in critically ill patients in tertiary hospitals in China.Methods: A multicenter prospective observational cohort study was performed with consecutively collected data from adults who stayed in any intensive care unit (ICU) for at least 24 h; data were collected from 1 January 2014 to 31 August 2015, and patients were followed until death or discharge from the hospital.Results: A total of 4,910 patients were enrolled in the study. Of these, 2,086 (42.5%) presented with sepsis or septic shock on admission to the ICU or within the first 48 h after admission to the ICU. ICU mortality was higher in patients with sepsis (13.1%) and septic shock (39.0%) and varied according to geographical region. Acinetobacter, Pseudomonas, and Staphylococcus infections were associated with increased ICU mortality. In addition, age, Acute Physiology, and Chronic Health Evaluation II (APACHE II) scores, pre-existing cardiovascular diseases, malignant tumors, renal replacement therapy (RRT), and septic shock were independent risk factors for mortality in patients with sepsis. The prompt administration of antibiotics (OR 0.65, 95% CI 0.46–0.92) and 30 mL/kg of initial fluid resuscitation during the first 3 h (OR 0.43, 95% CI 0.30–0.63) improved the outcome in patients with septic shock.Conclusions: Sepsis was common and was associated with a high mortality rate in critically ill patients in tertiary hospitals in China. The prompt administration of antibiotics and 30 mL/kg fluid resuscitation decreased the risk of mortality.

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Characteristics and outcomes of patients with community-acquired and hospital-acquired sepsis

Cited by 41 publications

References 28 publications

Comparison of Hospital- and Community-Acquired Septic Shock in Children: A Single-Center, Cohort, Retrospective Study

Comparison of Hospital- and Community-Acquired Septic Shock in Children: A Single-Center, Cohort, Retrospective Study

Risk Factors Associated With Increased Mortality in Septic Patients Admitted to the Intensive Care Unit/ Fatores De Risco Associados Ao Aumento Da Mortalidade Em Pacientes Sépticos Admitidos Na Unidade De Terapia Intensiva

The Prevalence, Risk Factors, and Outcomes of Sepsis in Critically Ill Patients in China: A Multicenter Prospective Cohort Study

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