Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units

Shekerdemian, Lara; Mahmood, Nabihah; Wolfe, Katie K.; Riggs, Becky J.; Ross, Catherine E.; McKiernan, Christine; Heidemann, Sabrina M.; Kleinman, Lawrence C.; Sen, Anita; Hall, Mark W.; Priestley, Margaret A.; McGuire, John K.; Boukas, Konstantinos; Sharron, Matthew; Burns, Jeffrey P.

doi:10.1001/jamapediatrics.2020.1948

Cited by 906 publications

(1,166 citation statements)

References 9 publications

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“…Corticosteroids were prescribed for two patients with resistant Kawasaki disease with giant aneurism and multiorgan failure. As with other studies, the prognosis of most patients was good (4,5,7,13,15). Almost all our patients discharged without complication, except one case with giant aneurysms.…”

Section: Discussionsupporting

confidence: 85%

“…Laboratory tests showed acute kidney injury and hepatic dysfunction in 3 and 2 patients, respectively. These ndings have had different results in the studies of Verdoni et al 5, Whittaker et al 7, Shekerdemian et al (13) and Chiotos et al (15). The increase in ESR and CRP, anemia, and leukopenia were similar to our case series.…”

Section: Discussioncontrasting

confidence: 61%

“…Given that standard treatment for the disease has not been identi ed, this report provides our experience in management of these patients. Although children with COVID-19 are more likely to present fever and respiratory or gastrointestinal symptoms (13)(14)(15), but the most common presentation of our cases (8 cases of 10) at the time of onset was fever and rash with no respiratory symptoms, like the report of Whittaker et al (7) and only 3 of our cases had cough or any other respiratory complaints. On the other hand, 2 of our patients didn't show any respiratory complaints.…”

Section: Discussionsupporting

confidence: 53%

“…In echocardiography, ejection fraction reduced in three cases, and in two cases, ectasia and in one patient aneurysm were reported. As reported by Verdoni et al (13), and Chiotos et al (15), almost all these patients were admitted to PICU ward. In addition to supportive care like hydration, albumin infusion, packed cell transfusion, appropriate antibiotics, and chloroquine, IVIG was given to 6 patients at a dose of 1 g/kg and in three patients at a dose of 2 g/kg.…”

Section: Discussionmentioning

confidence: 66%

“…However, three to four days after hospitalization, almost all patients developed respiratory symptoms like Shekerdemian et al's report (13). One of these patients had uncontrollable seizures and fever, with no other serious symptoms at the time of admission.…”

Section: Discussionmentioning

confidence: 86%

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Clinical Characteristics of Pediatric Inflammatory Multisystem Syndrome Associated With COVID-19

Shahbaznejad¹,

Navaifar²,

Abbaskhanian³

et al. 2020

Preprint

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Background: Although symptoms and signs of COVID-19 (Coronavirus disease 2019) in children are milder than adults, there are reports of more severe cases which was defined as pediatric inflammatory multisystem syndrome (PIMS). The purpose of this report is to describe possible association between COVID-19 and PIMS in children. Methods: From 28 March to 24 June 2020, 10 febrile children were admitted with COVID-19 infection showing characteristics of PIMS in a tertiary hospital in the north of Iran. Demographic and clinical characteristics, laboratory and imaging findings and therapeutic modalities were recorded and analysed. Results: The mean age of patients was 5.37±3.9 years (13 months to 12 years). Six of them were boy. Kawasaki disease, myocarditis, toxic shock syndrome, appendicitis, sepsis, urosepsis, prolonged febrile seizure, acute hemorrhagic edema of infancy, and COVID-19-related pneumonia were their first impression. All of them had increased C-reactive protein level and most of them had an elevated erythrocyte sedimentation rate, lymphopenia, anemia, and hypoalbuminemia. Some of them had thrombocytopenia. Six of them were serologically or polymerase chain reaction positive for COVID-19, and 4 of them were diagnosed as COVID-19 just by chest computed tomography scan. Most of the patients improved without a residual sequel, except one who died with multiorgan failure and another case discharged with a giant coronary aneurysm.Conclusion: Children with COVID-19 may present symptoms similar to Kawasaki disease and inflammatory syndromes. PIMS should be considered in children with fever and rash, seizure, cough, tachypnea, and gastrointestinal symptoms such as vomiting, diarrhea, and abdominal pain.

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Section: Discussionsupporting

confidence: 85%

Section: Discussioncontrasting

confidence: 61%

Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 86%

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Clinical Characteristics of Pediatric Inflammatory Multisystem Syndrome Associated With COVID-19

Shahbaznejad¹,

Navaifar²,

Abbaskhanian³

et al. 2020

Preprint

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Estimation of US Children’s Educational Attainment and Years of Life Lost Associated With Primary School Closures During the Coronavirus Disease 2019 Pandemic

2020

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Key Points Question Based on the current understanding of the associations between school disruption and decreased educational attainment and between decreased educational attainment and lower life expectancy, is it possible to estimate the association between school closure during the coronavirus disease 2019 pandemic and decreased life expectancy of publicly educated primary school–aged children in the United States? Findings This decision analytical model found that missed instruction during 2020 could be associated with an estimated 5.53 million years of life lost. This loss in life expectancy was likely to be greater than would have been observed if leaving primary schools open had led to an expansion of the first wave of the pandemic. Meaning These findings suggest that the decision to close US public primary schools in the early months of 2020 may be associated with a decrease in life expectancy for US children.

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Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children

et al. 2021

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Key Points Question Among children with a COVID-19 diagnosis, what conditions are common, and which are associated with severe COVID-19 illness? Findings In this cross-sectional study of 43 465 patients aged 18 years or younger with COVID-19, more than one-quarter had 1 or more underlying condition; asthma, obesity, neurodevelopmental disorders, and certain mental health conditions were most common. Certain conditions as well as medical complexity were associated with a higher risk of severe COVID-19 illness. Meaning These findings expand the knowledge available regarding children with COVID-19 and could inform pediatric clinical practice and public health priorities, such as prevention and mitigation of COVID-19.

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Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units

Cited by 906 publications

References 9 publications

Clinical Characteristics of Pediatric Inflammatory Multisystem Syndrome Associated With COVID-19

Clinical Characteristics of Pediatric Inflammatory Multisystem Syndrome Associated With COVID-19

Estimation of US Children’s Educational Attainment and Years of Life Lost Associated With Primary School Closures During the Coronavirus Disease 2019 Pandemic

Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children

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