Characteristics and in vitro release of dextromethorphan resinates

Prakongpan, Sompol; Rungsardthong, U.; Chancham, P.; Priprem, Aroonsri

doi:10.1016/j.powtec.2005.01.017

Cited by 20 publications

(17 citation statements)

References 17 publications

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“…Toxicokinetic data on humans in vivo [Benowitz et al 1991;Gorsline et al 1992;D'Alesandro et al 2001;Onuki et al 2003] and in vitro [Zorin et al 1999;Pongjanyajul et al 2000] and data on animals [Shah et al 1981;Matsushima et al 1995] Nicotine system effects, cerebrovascular disease with prolonged exposure, and developmental effects, including pregnancy loss in rats. Therefore, on the basis of the data for this assessment, nicotine is assigned the SK: SYS notation.…”

Section: Nicotinementioning

confidence: 99%

NIOSH skin notation (SK) profile: nicotine [CAS No. 54-11-5].

Hudson¹,

Dotson²

2015

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Section: Nicotinementioning

confidence: 99%

NIOSH skin notation (SK) profile: nicotine [CAS No. 54-11-5].

Hudson¹,

Dotson²

2015

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“…Moreover, a comparable DMP release rate in both media was found, although the cation concentration of SGF was higher than that of SIF. 15 This result was due to the influence of pH that affected the ionization of DMP. The higher pH of SIF caused a lower ionized form of DMP in the resinate.…”

Section: Scale-up Production Studiesmentioning

confidence: 99%

“…This finding was in agreement with the previous report. 15 Moreover, the release of DMP from the resinate tablets was also investigated using 0.1 N HCl for 2 hours and followed with pH 6.8 phosphate buffer that was a simulated GI condition. The release profiles of DMP resinate tablets proceeded continuously when changing the dissolution medium from acid stage to pH 6.8 buffer stage (Figure 6), indicating that the release of DMP could take place continuously in GI conditions.…”

Section: Scale-up Production Studiesmentioning

confidence: 99%

“…Thus the release of DMP was mainly controlled by the resinates. 6 Drug released from ion exchange resins is driven by the exchange of ions toward an equilibrium, 7,14,15 which is likely to occur with a substantial percentage of drug still bound to the resins, even under sink conditions. This is a problem that occurs with a fixed-volume dissolution apparatus because it does not obtain a complete drug-release profile.…”

Section: Introductionmentioning

confidence: 99%

“…For example, DMP released from the resinates was~60% and 65% of total drug loading in simulated gastric and intestinal fluids, respectively. 15 Thus, continuous release of the drug from the resinates may be achieved by changing almost all the release medium in order to maintain the ion exchange process. However, this method causes the process to become complicated.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of sampling procedures of release testing on drug release and scale-up production feasibility of multiple-unit dextromethorphan resinate tablets: A technical note

Pongjanyakul

2007

AAPS PharmSciTech

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Drug Release Properties of Polymer Coated Ion-Exchange Resin Complexes: Experimental and Theoretical Evaluation

Jeong

Berhane

Haghighi

et al. 2007

Journal of Pharmaceutical Sciences

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Although ion-exchange resins have been used widely as drug delivery systems, their exact release kinetics has not been reported yet. Usually only the rate-limiting step has been taken into account and the rest of the steps have been ignored as instantaneous processes. To investigate the exact release kinetics of polymer-coated drug/ion-exchange resin complexes for sustained drug delivery, the results of new mathematical modeling were compared with experimental results. Drug/resin complexes with a model drug, dextromethorphan, were prepared and used as cores for fluid-bed coating. An aqueous colloidal dispersion of poly(vinyl acetate) was applied for the coating. A comprehensive mathematical model was developed using a mechanistic approach by considering diffusion, swelling, and ion-exchange processes solved by numerical techniques. The rate-limiting factor of the uncoated resin particles was diffusion through the core matrix. Similarly, in the coated particles the rate-limiting factor was diffusion through the coating membrane. The mathematical model has captured the phenomena observed during experimental evaluations and the release dynamics from uncoated and coated (at different coat levels) particles were predicted accurately (maximum RMSE 2.4%). The mathematical model is a useful tool to theoretically evaluate the drug release properties from coated ion-exchange complexes thus can be used for design purposes.

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Characteristics and in vitro release of dextromethorphan resinates

Cited by 20 publications

References 17 publications

NIOSH skin notation (SK) profile: nicotine [CAS No. 54-11-5].

NIOSH skin notation (SK) profile: nicotine [CAS No. 54-11-5].

Effect of sampling procedures of release testing on drug release and scale-up production feasibility of multiple-unit dextromethorphan resinate tablets: A technical note

Drug Release Properties of Polymer Coated Ion-Exchange Resin Complexes: Experimental and Theoretical Evaluation

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