Characteristics and implications of Omicron variant associated digestive system infections – Correspondence

Yunjie, Shi; Mei, Zubing; Wang, Hao

doi:10.1016/j.ijsu.2022.106750

Cited by 6 publications

(7 citation statements)

References 11 publications

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“…According to the Shanghai experience, gastrointestinal symptoms caused by Omicron variations are rather infrequent compared to other variants. The researchers observed that the Omicron variant strain had a lower proliferation efficiency in the intestinal model( Shi et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Molecular dynamic and bioinformatic studies of metformin-induced ACE2 phosphorylation in the presence of different SARS-CoV-2 S protein mutations

El‐Arabey

Abdalla

Abd-Allah

et al. 2023

Saudi Journal of Biological Sciences

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Section: Discussionmentioning

confidence: 99%

Molecular dynamic and bioinformatic studies of metformin-induced ACE2 phosphorylation in the presence of different SARS-CoV-2 S protein mutations

El‐Arabey

Abdalla

Abd-Allah

et al. 2023

Saudi Journal of Biological Sciences

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“…This may be a clue to explain the narrower tissue specificity of Omicron in comparison with earlier variants. The pathology of Omicron infection is more localized to the respiratory system, resulting in fewer symptoms in the digestive and nervous systems [42,86,87]. Interestingly, in the airway epithelial carcinoma cell line Calu-3, the deficiency of Omicron was less dramatic, presumably due to its adaptation to airway cells [85].…”

Section: Phenotypic Loss Due To Genetic Degradationmentioning

confidence: 99%

Attenuation and Degeneration of SARS-CoV-2 Despite Adaptive Evolution

Liu¹

2023

Cureus

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The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has followed similar trends as other RNA viruses, such as human immunodeficiency virus type 1 and the influenza A virus. Rapid initial diversification was followed by strong competition and a rapid succession of dominant variants. Hostinitiated RNA editing has been the primary mechanism for introducing mutations. A significant number of mutations detrimental to viral replication have been quickly purged. Fixed mutations are mostly diversifying mutations selected for host adaptation and immune evasion, with the latter accounting for the majority of the mutations. However, immune evasion often comes at the cost of functionality, and thus, optimal functionality is still far from being accomplished. Instead, selection for antibody-escaping variants and accumulation of near-neutral mutations have led to suboptimal codon usage and reduced replicative capacity, as demonstrated in non-respiratory cell lines. Beneficial adaptation of the virus includes reduced infectivity in lung tissues and increased tropism for the upper airway, resulting in shorter incubation periods, milder diseases, and more efficient transmission between people.

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“…This may be a clue to explain the narrower tissue specificity of Omicron in comparison with earlier variants. The pathology of Omicron infection is more localized to the respiratory system, resulting in less symptoms of the digestive and nervous systems [37,80,81]. Interestingly, in the airway epithelial carcinoma cell line Calu-3, the disadvantage of Omicron was less dramatic, presumably due to its adaptation to airway cells [79].…”

Section: Reduced Replication Capacity In Non-respiratory Cell Linesmentioning

confidence: 99%

<strong>Attenuation and Degeneration of SARS-CoV-2 Despite of Adaptive Evolution</strong>

Liu¹

2022

Preprint

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Evolution of SARS-CoV-2 has followed similar trends as other RNA viruses, e.g., HIV-1 and influenza A. Rapid initial diversification was followed by strong competition and rapid succession of dominant variants. Host-initiated RNA editing has been the primary mechanism for introducing mutations. A significant number of mutations were detrimental and were quickly purged. Fixed mutations are mostly diversifying mutations selected for host adaptation and immune evasion, with the latter accounting for more of the changes. However, immune evasion often comes at the cost of functionality, so that optimal functionality is still far from being accomplished. Instead, selection for antibody-escaping variants and accumulation of near-neutral mutations has led to suboptimal codon usage and reduced replicative capacity as demonstrated in non-respiratory cell lines. Beneficial adaptation of the virus includes reduced infectivity in lung tissues and increased tropism for the upper airway, resulting in shorter incubation periods, milder diseases, and more efficient transmission between people.

show abstract

Characteristics and implications of Omicron variant associated digestive system infections – Correspondence

Cited by 6 publications

References 11 publications

Molecular dynamic and bioinformatic studies of metformin-induced ACE2 phosphorylation in the presence of different SARS-CoV-2 S protein mutations

Molecular dynamic and bioinformatic studies of metformin-induced ACE2 phosphorylation in the presence of different SARS-CoV-2 S protein mutations

Attenuation and Degeneration of SARS-CoV-2 Despite Adaptive Evolution

<strong>Attenuation and Degeneration of SARS-CoV-2 Despite of Adaptive Evolution</strong>

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