Characteristics and Echogenicity of Clinical Ultrasound Contrast Agents: An In Vitro and In Vivo Comparison Study

Hyvelin, Jean-Marc; Gaud, Emmanuel; Costa, Maria Célia Pires; Helbert, Alexandre; Bussat, Philippe; Bettinger, Thierry; Frinking, Peter

doi:10.7863/ultra.16.04059

Cited by 55 publications

(53 citation statements)

References 34 publications

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“…During the operation and in addition to the acquisition of intraoperative B-mode ultrasound volumes (noted 3D-iUS), two 3D intraoperative contrast enhanced ultrasound (3D-iCEUS) data were acquired after the injection of 4.8 milliliter of an ultrasound contrast agent (SonoVue, Bracco s.p.a., Milan, Italy) at a rate of 3.0 mL/min using a syringe pump (ACIST VueJect, Bracco s.p.a, Milano, Italy) and using the contrast harmonic imaging (CHI) method. The size and density of the micro-bubbles in the SonoVue contrast agent was 1.9 ± 0.1 micromillimeter and 3.4 ± 0.5 micro-bubbles/mL as recently reported in [ 24 ]. The first volume, denoted 3D-iCEUS

, was obtained transdurally immediately after the craniotomy when the tumor was still entire, and the second one, denoted 3D-iCEUS

, was acquired after removing the tumor at the end of the surgery.…”

Section: Methodssupporting

confidence: 78%

Vascular Structure Identification in Intraoperative 3D Contrast-Enhanced Ultrasound Data

Ilunga-Mbuyamba

Aviña-Cervantes

Lindner

et al. 2016

Sensors

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In this paper, a method of vascular structure identification in intraoperative 3D Contrast-Enhanced Ultrasound (CEUS) data is presented. Ultrasound imaging is commonly used in brain tumor surgery to investigate in real time the current status of cerebral structures. The use of an ultrasound contrast agent enables to highlight tumor tissue, but also surrounding blood vessels. However, these structures can be used as landmarks to estimate and correct the brain shift. This work proposes an alternative method for extracting small vascular segments close to the tumor as landmark. The patient image dataset involved in brain tumor operations includes preoperative contrast T1MR (cT1MR) data and 3D intraoperative contrast enhanced ultrasound data acquired before (3D-iCEUSstart) and after (3D-iCEUSend) tumor resection. Based on rigid registration techniques, a preselected vascular segment in cT1MR is searched in 3D-iCEUSstart and 3D-iCEUSend data. The method was validated by using three similarity measures (Normalized Gradient Field, Normalized Mutual Information and Normalized Cross Correlation). Tests were performed on data obtained from ten patients overcoming a brain tumor operation and it succeeded in nine cases. Despite the small size of the vascular structures, the artifacts in the ultrasound images and the brain tissue deformations, blood vessels were successfully identified.

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, was obtained transdurally immediately after the craniotomy when the tumor was still entire, and the second one, denoted 3D-iCEUS

, was acquired after removing the tumor at the end of the surgery.…”

Section: Methodssupporting

confidence: 78%

Vascular Structure Identification in Intraoperative 3D Contrast-Enhanced Ultrasound Data

Ilunga-Mbuyamba

Aviña-Cervantes

Lindner

et al. 2016

Sensors

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“…In addition, the positioning of ROI 2 -4 of likely benign lesions as well as the lack of histological correlation of these regions need to be mentioned as a potential study bias. To our knowledge, there are only a few studies [27,28] investigating the potential value of using quantification software for the interpretation of CEUS in the prostate as well as other organs and thus further long-term multimodality imaging studies should be conducted. Furthermore, we ▶ did not include an analysis of interreader agreement which seems to be increased based on CEUS [29].…”

Section: Discussionmentioning

confidence: 99%

Contrast-Enhanced Ultrasound (CEUS) and Quantitative Perfusion Analysis in Patients with Suspicion for Prostate Cancer

et al. 2018

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“…To enhance the echogenicity and ultrasound responsiveness of certain tissues, microbubbles were developed as contrast agents. They basically consists of various gases enhancing echogenicity stabilized within a lipid or protein shell [11,12]. It is thus possible to obtain 2D and 3D images of tissues and organs [3].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

327

247

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• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

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Characteristics and Echogenicity of Clinical Ultrasound Contrast Agents: An In Vitro and In Vivo Comparison Study

Abstract: Imaging performance of SonoVue was similar to or slightly better than that of Definity, but it was superior to Optison for the conditions used in this study.

Cited by 55 publications

References 34 publications

Vascular Structure Identification in Intraoperative 3D Contrast-Enhanced Ultrasound Data

Vascular Structure Identification in Intraoperative 3D Contrast-Enhanced Ultrasound Data

Contrast-Enhanced Ultrasound (CEUS) and Quantitative Perfusion Analysis in Patients with Suspicion for Prostate Cancer

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

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