Characteristics and Clinical Outcomes of Adult Patients Hospitalized with COVID-19 — Georgia, March 2020

Gold, Jeremy A W; Wong, Karen K.; Szablewski, Christine M.; Patel, Priti R.; Rossow, John; Silva, Juliana da; Natarajan, Pavithra; Morris, Sapna Bamrah; Fanfair, Robyn Neblett; Rogers-Brown, Jessica; Bruce, Bonnie; Browning, Sean; Hernández-Romieu, Alfonso C; Furukawa, Nathan W.; Kang, Mohleen; Evans, Mary; Oosmanally, Nadine; Tobin-D’Angelo, Melissa; Drenzek, Cherie; Murphy, David J.; Hollberg, Julie; Blum, James M.; Jansen, Robert D.; Wright, David W.; Sewell, William M.; Owens, Jack; Lefkove, Benjamin; Brown, Frank; Burton, Deron C.; Uyeki, Timothy M.; Bialek, Stephanie R.; Jackson, Brendan R

doi:10.15585/mmwr.mm6918e1

Cited by 447 publications

(514 citation statements)

References 5 publications

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“…Despite this, neither age or BMI signi cantly correlated with mortality or successful extubation rates. Although the literature recognizes a linear relationship between elderly and obese patients with severity of disease 5,7 , we found that among those who were already intubated (critically ill) the above risk factors did not predict outcomes. The same ndings are also applicable to gender and race.…”

Section: Discussioncontrasting

confidence: 65%

“…The COVID-19 pandemic has spread rapidly across the United States (US) becoming the leading country by number of people infected and associated deaths 5,6 . As of April 20 th , 2020, the rate of infection in New York (NY) has exceeded every other state becoming more than 30% of all of the US cases 7 .…”

Section: Introductionmentioning

confidence: 99%

“…There is a lack of data despite increased incidence, in high population density areas 3 . Detailed data on demographic characteristics, underlying medical conditions, and potential interventions for hospitalized patients with COVID-19 are needed to conjugate prevention strategies and community speci c interventions 5,9 . In order to improve care and to reduce mortality, we highlight the need for studies to assess mechanisms behind increased disease severity.…”

Section: Introductionmentioning

confidence: 99%

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Mortality Data in Mechanically Ventilated COVID-19 patients admitted to ICU: A Retrospective Study in Brooklyn

Patti

Duarte

Dalsania

et al. 2020

Preprint

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Background: High mortality rates are predominant even in COVID-19 patients requiring minimal supportive therapy, with a short-coming of data on COVID-19 patients requiring mechanical ventilation.Objectives/Design: We performed a single-center, retrospective, cohort study at a tertiary care, community-based teaching hospital with patient who required invasive mechanical ventilatory support and were COVID-19 positive. All patients were treated according to the ARDSnet protocol. The primary outcome was overall mortality, and secondary outcome was successful extubation.Results: A total of 72 COVID-19 positive intubated patients were included. Twenty-six (66.6%) patients died within the first 15 days of hospital admission; thirty-eight (52.7%) died within 28 days, and thirty-nine (54.2%) died within 29 days. A total of 22 patients (30.5%) were successfully extubated. 15 patients (20.8%) who required reintubation or could not be extubated further underwent tracheostomy.Conclusions: Mortality of critically ill COVID-19 patients requiring mechanical ventilatory support is high, our observed mortality rate (54.2%) was significantly lower than currently published reports. We believe our rate to be a consequence of early intubation in conjunction with adherence to ARDSnet protocol. We also observed patients with hyperlipidemia, higher CRP, renal failure, or those requiring vasopressor use had worse outcomes.

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Section: Discussioncontrasting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mortality Data in Mechanically Ventilated COVID-19 patients admitted to ICU: A Retrospective Study in Brooklyn

Patti

Duarte

Dalsania

et al. 2020

Preprint

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“…There is also growing evidence that COVID-19 tends to disproportionately affect African Americans in the United States [29,30], and that those of black and ethnic minority origins have more severe disease [31]. Due to reduced vitamin D production from skin pigmentation, there is a higher prevalence of vitamin D deficiency in dark-skin individuals [32].…”

Section: Vitamin D Deficiency and Possible Links With Covid-19mentioning

confidence: 99%

Are Adequate Vitamin D Levels Helpful in Fighting COVID-19? A Look at the Evidence

Hoong

Cho

et al. 2020

Horm Metab Res

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COVID-19 is a global pandemic with high mortality in vulnerable groups. Given the current lack of definitive treatment or vaccine that significantly reduces mortality rate, governments, researchers and healthcare providers are racing to find possible solutions to the crisis. Vitamin D and its analogues have been previously studied for their non-skeletal benefits. In particular, questions regarding their role in the modulation of immunity have re-surfaced, in view of possible epidemiological links observed between COVID-19 and vitamin D levels in selected populations. In this review, we highlight potential mechanisms and summarise the evidence for and against the potential role of vitamin D supplementation in our fight against COVID-19.

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“…Given its high prevalence, high transmissibility, and lack of established therapeutic and preventative agents, SARS‐CoV‐2 will likely infect the majority of adults and children. Therefore, defining potential associations of SARS‐CoV‐2 with future cancer risk, especially in minority populations, 48,49 seems warranted. As an example, in utero cytomegalovirus (CMV) infection has been associated with subsequent ALL risk (OR = 3.71, P = .0016) most pronounced in Hispanics (OR = 5.90, P = .0006) and hypothesized to occur given the supportive role of CMV in oncogenesis through induction of chromosomal instability and immune dysregulation 50 .…”

Section: Introductionmentioning

confidence: 99%

Pediatric cancer research: Surviving COVID‐19

Auletta

Adamson

Agin

et al. 2020

Pediatric Blood & Cancer

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A diverse panel of pediatric cancer advocates and experts, whose collective experience spans the continuum of international academic medicine, industry, government research, and cancer advocacy, recently discussed challenges for pediatric cancer research in the context of coronavirus disease 2019 (COVID‐19). Specifically, this special report addresses the following focus areas: (a) the critical role that translational research has played in transforming pediatric cancer outcomes; (b) the current and potential future impact of COVID‐19 on pediatric cancer research; (c) target areas of COVID‐19 research that may have application in immunity, oncogenesis, and therapeutic discovery; and (d) future considerations and directions in maintaining pediatric cancer research during and after COVID‐19.

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Characteristics and Clinical Outcomes of Adult Patients Hospitalized with COVID-19 — Georgia, March 2020

Cited by 447 publications

References 5 publications

Mortality Data in Mechanically Ventilated COVID-19 patients admitted to ICU: A Retrospective Study in Brooklyn

Mortality Data in Mechanically Ventilated COVID-19 patients admitted to ICU: A Retrospective Study in Brooklyn

Are Adequate Vitamin D Levels Helpful in Fighting COVID-19? A Look at the Evidence

Pediatric cancer research: Surviving COVID‐19

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