Characteristics and Clinical Outcomes of Children and Adolescents Aged &lt;18 Years Hospitalized with COVID-19 — Six Hospitals, United States, July–August 2021

Wanga, Valentine; Gerdes, Megan E.; Shi, Dallas S.; Choudhary, Rewa; Dulski, Theresa M.; Hsu, Sophia; Idubor, Osatohamwen I.; Webber, Bryant J.; Wendel, Arthur M.; Agathis, Nickolas T.; Anderson, Kristi; Boyles, Tricia; Chiu, Sophia; Click, Eleanor S.; Silva, Juliana da; Dupont, Hannah; Evans, Mary; Gold, Jeremy A W; Haston, Julia C.; Logan, Pamela; Maloney, Susan A.; Martínez, Marisol; Natarajan, Pavithra; Spicer, Kevin B.; Swancutt, Mark A.; Stevens, Valerie A.; Brown, Jessica; Chandra, Gyan; Light, Megan; Barr, Frederick E.; Snowden, Jessica; Kociolek, Larry K.; McHugh, Matthew D.; Wessel, David; Simpson, Joelle; Gorman, Kathleen; Breslin, Kristen; DeBiasi, Roberta L.; Thompson, Aaron; Kline, Mark W.; Bloom, Julie A.; Singh, Ila R.; Dowlin, Michael; Wietecha, Mark; Schweitzer, Beth; Morris, Sapna Bamrah; Koumans, Emily H.; Ko, Jean Y.; Kimball, Anne; Siegel, David A.

doi:10.15585/mmwr.mm705152a3

Cited by 86 publications

(74 citation statements)

References 9 publications

(15 reference statements)

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“…Findings suggest that incidental admissions do not account for the increase in hospitalization rates observed during the Omicron period. Throughout the COVID-19 pandemic, admissions for reasons other than COVID-19 have been recorded ( 8 , 9 ), and during both the Delta- and Omicron-predominant periods, incidental admissions were more likely among fully vaccinated adolescents. Reasons for admission should continue to be monitored as more children and adolescents become fully vaccinated.…”

Section: Discussionmentioning

confidence: 99%

Hospitalizations of Children and Adolescents with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, July 2021–January 2022

Marks¹,

Whitaker²,

Anglin³

et al. 2022

MMWR Morb. Mortal. Wkly. Rep.

150

121

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this report was posted as an MMWR Early Release on the MMWR website (https://www.cdc.gov/mmwr). The first U.S. case of COVID-19 attributed to the Omicron variant of SARS-CoV-2 (the virus that causes COVID-19) was reported on December 1, 2021 (1), and by the week ending December 25, 2021, Omicron was the predominant circulating variant in the United States.* Although COVID-19-associated hospitalizations are more frequent among adults, † COVID-19 can lead to severe outcomes in children and adolescents (2). This report analyzes data from the Coronavirus Disease 19-Associated Hospitalization Surveillance Network (COVID-NET) § to describe COVID-19-associated hospitalizations among U.S. children (aged 0-11 years) and adolescents (aged 12-17 years) during periods of Delta (

show abstract

Section: Discussionmentioning

confidence: 99%

Hospitalizations of Children and Adolescents with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, July 2021–January 2022

Marks¹,

Whitaker²,

Anglin³

et al. 2022

MMWR Morb. Mortal. Wkly. Rep.

150

121

View full text Add to dashboard Cite

show abstract

“…Likely contributors to low vaccination coverage include vaccine hesitancy among parents and caregivers and potential need for alternative convenient, trusted vaccine access points ( 2 ). With pediatric COVID-19 vaccine readily available in most communities, ongoing strategies to improve coverage could focus on improving vaccine confidence among caregivers through provision of information from trusted messengers, such as faith and community leaders, about the impact of COVID-19 among children ( 4 – 7 ) and the safety and effectiveness of COVID-19 vaccination ( 8 , 9 ) in culturally relevant and accessible formats to address community-level concerns ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccine Provider Access and Vaccination Coverage Among Children Aged 5–11 Years — United States, November 2021–January 2022

Kim¹,

Yee²,

Bhatkoti³

et al. 2022

MMWR Morb. Mortal. Wkly. Rep.

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“…Among hospitalized children, 22% with influenza and 26% with COVID-19 required ICU admission, and 5% with influenza and 6% with COVID-19 required mechanical ventilation. Another analysis of COVID-19 hospitalizations among children < 18 years old during July–August 2021, when the B.1.617.2 (Delta) variant of SARS-CoV-2 was predominant, showed similar findings with 29.5% requiring ICU admission and 7.9% requiring mechanical ventilation [27]. COVID-19 also can lead to multisystem inflammatory syndrome [29] and other longer-term sequelae [30].…”

Section: Discussionmentioning

confidence: 99%

Comparison of influenza and COVID-19–associated hospitalizations among children < 18 years old in the United States — FluSurv-NET (October–April 2017–2021) and COVID-NET (October 2020–September 2021)

Delahoy

Ujamaa

Taylor

et al. 2022

Preprint

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Background: Influenza virus and SARS-CoV-2 are significant causes of respiratory illness in children. Methods: Influenza and COVID-19-associated hospitalizations among children <18 years old were analyzed from FluSurv-NET and COVID-NET, two population-based surveillance systems with similar catchment areas and methodology. The annual COVID-19-associated hospitalization rate per 100 000 during the ongoing COVID-19 pandemic (October 1, 2020-September 30, 2021) was compared to influenza-associated hospitalization rates during the 2017-18 through 2019-20 influenza seasons. In-hospital outcomes, including intensive care unit (ICU) admission and death, were compared. Results: Among children <18 years old, the COVID-19-associated hospitalization rate (48.2) was higher than influenza-associated hospitalization rates: 2017-18 (33.5), 2018-19 (33.8), and 2019-20 (41.7). The COVID-19-associated hospitalization rate was higher among adolescents 12-17 years old (COVID-19: 59.9; influenza range: 12.2-14.1), but similar or lower among children 5-11 (COVID-19: 25.0; influenza range: 24.3-31.7) and 0-4 (COVID-19: 66.8; influenza range: 70.9-91.5) years old. Among children <18 years old, a higher proportion with COVID-19 required ICU admission compared with influenza (26.4% vs 21.6%; p<0.01). Pediatric deaths were uncommon during both COVID-19- and influenza-associated hospitalizations (0.7% vs 0.5%; p=0.28). Conclusions: In the setting of extensive mitigation measures during the COVID-19 pandemic, the annual COVID-19-associated hospitalization rate during 2020-2021 was higher among adolescents and similar or lower among children <12 years old compared with influenza during the three seasons before the COVID-19 pandemic. COVID-19 adds substantially to the existing burden of pediatric hospitalizations and severe outcomes caused by influenza and other respiratory viruses.

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Characteristics and Clinical Outcomes of Children and Adolescents Aged <18 Years Hospitalized with COVID-19 — Six Hospitals, United States, July–August 2021

Cited by 86 publications

References 9 publications

Hospitalizations of Children and Adolescents with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, July 2021–January 2022

Hospitalizations of Children and Adolescents with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, July 2021–January 2022

COVID-19 Vaccine Provider Access and Vaccination Coverage Among Children Aged 5–11 Years — United States, November 2021–January 2022

Comparison of influenza and COVID-19–associated hospitalizations among children < 18 years old in the United States — FluSurv-NET (October–April 2017–2021) and COVID-NET (October 2020–September 2021)

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