Characteristics and changes in invasive meningococcal disease epidemiology in France, 2006–2015

Châtelet, Isabelle Parent du; Deghmane, Ala‐Eddine; Antona, Denise; Hong, Eva; Fonteneau, Laure; Taha, Muhamed‐Kheir; Lévy-Brühl, Daniel

doi:10.1016/j.jinf.2017.02.011

Cited by 49 publications

(54 citation statements)

References 35 publications

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“… reported a lower prevalence of SBIs (7.2%) and IBIs (0.4%) from data collected between 2004 and 2006, which could be explained by the high level of vaccine coverage and herd immunity in Australia . However, despite suboptimal vaccination coverage in France, IBIs have decreased in recent years following steady advances in the pneumococcal conjugate and the decrease in group C invasive meningococcal disease .…”

Section: Discussionmentioning

confidence: 67%

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Procalcitonin and C‐reactive protein may help to detect invasive bacterial infections in children who have fever without source

et al. 2018

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Section: Discussionmentioning

confidence: 67%

“…This prospective study of children under the age of five presenting with FWS in a university PED in France reported that SBIs and IBIs occurred in 11.9% (95% CI: 10.1%-14.0%) and 1.0% (95% CI: 0.4%-1.6%), respectively. the pneumococcal conjugate and the decrease in group C invasive meningococcal disease (22,23).…”

Section: Discussionmentioning

confidence: 99%

Procalcitonin and C‐reactive protein may help to detect invasive bacterial infections in children who have fever without source

et al. 2018

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“…As in England, the epidemiology of MenW disease has changed substantially since 2000 in France. An increase of MenW disease associated with the Hajj strain was also observed in the early 2000s, but quickly receded and MenW caused few cases during 2006-2011 [23,31]. Unlike in England, however, new cases of the Hajj strain were reported from 2012, but the increase was transient and mostly associated with recent travel to sub-Saharan countries [54,55].…”

Section: Discussionmentioning

confidence: 97%

“…Data in France were provided by the National Reference Centre for Meningococci [31]. These data consisted of the age-stratified counts of non-MenW:cc11 IMD cases during 2010/2011-2016/2017 and of MenW:cc11/ SA cases during 2012/2013-2018/2019 [23].…”

Section: Datamentioning

confidence: 99%

Transmissibility and pathogenicity of the emerging meningococcal serogroup W sequence type-11 complex South American strain: a mathematical modeling study

Cellès

Campbell

Borrow

et al. 2020

BMC Med

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Background: The recent emergence of strains belonging to the meningococcal serogroup W (MenW) sequence type-11 clonal complex and descending from the South American sub-lineage (MenW:cc11/SA) has caused significant shifts in the epidemiology of meningococcal disease worldwide. Although MenW:cc11/SA is deemed highly transmissible and invasive, its epidemiological characteristics have not yet been quantified. Methods: We designed a mathematical model of MenW transmission, carriage, and infection to analyze the recent epidemiology of invasive disease caused by MenW:cc11/SA strains and by other MenW strains in England and in France. We confronted that model with age-stratified incidence data to estimate the transmissibility and the invasiveness of MenW:cc11/SA in England, using the data in France as a validation cohort. Results: During the epidemiological years 2010/2011-2014/2015 in England, the transmissibility of MenW:cc11/SA relative to that of other MenW strains was estimated at 1.20 (95% confidence interval, 1.15 to 1.26). The relative invasiveness of MenW:cc11/SA was also found to exceed unity and to increase with age, with estimates ranging from 4.0 (1.6 to 9.7) in children aged 0-4 years to 20 (6 to 34) in adults aged ≥ 25 years. In France, the model calibrated in England correctly reproduced the early increase of MenW:cc11/SA disease during 2012/2013-2016/2017. Most recent surveillance data, however, indicated a decline in MenW:cc11/SA disease. In both countries, our results suggested that the transmission of MenW:cc11/SA carriage possibly started several months before the first reported case of MenW:cc11/SA disease. Discussion: Our results confirm earlier suggestions about the transmission and the pathogenic potential of MenW:cc11/SA. The main limitation of our study was the lack of age-specific MenW carriage data to confront our model predictions with. Furthermore, the lesser model fit to the most recent data in France suggests that the predictive accuracy of our model might be limited to 5-6 years.(Continued on next page)

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“…We screened the database of the French National reference centre for meningococci and Haemophilus in uenzae (NRCMHi) for biologically con rmed IMD cases (meningococci detected by culture and/or from a normally sterile site) and compared data for the period between 01 January and 15 May of 2019 and 2020. Meningococcal isolates are sent to the NRCMHi for full typing (MLST and WGS) as part of the mandatory reporting of IMD (9). A total of 305 cases of IMD were received at the NRCMHi for the two studied periods (176 in 2019 and 129 in 2020).…”

Section: Main Textmentioning

confidence: 99%

Impact of COVID-19 pandemic and the lockdown on invasive meningococcal disease

Taha

Deghmane

2020

Preprint

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Objective: Few data are available on the association between SARS-CoV-2 and secondary bacterial infections. Such an association was described for flu and invasive meningococcal disease (IMD). We aimed exploring such a correlation between COVID-19and IMD.Results: We compared IMD cases received at the French National Reference Centre for meningococci and Haemophilus influenzae that are sent as part of the mandatory reporting of IMD. We compared these data during the period 01 January-15 May 2020 to those from the same period in 2019. IMD cases that were associated with respiratory presentations significantly increased in 2020, involved elderly and were due to unusual isolates. However, usual IMD cases due to highly transmissible isolates decreased during the lockdown. Enhancing IMD surveillance and anti-meningococcal vaccination in elderly should to be addressed.

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Characteristics and changes in invasive meningococcal disease epidemiology in France, 2006–2015

Cited by 49 publications

References 35 publications

Procalcitonin and C‐reactive protein may help to detect invasive bacterial infections in children who have fever without source

Procalcitonin and C‐reactive protein may help to detect invasive bacterial infections in children who have fever without source

Transmissibility and pathogenicity of the emerging meningococcal serogroup W sequence type-11 complex South American strain: a mathematical modeling study

Impact of COVID-19 pandemic and the lockdown on invasive meningococcal disease

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