Characteristic of the Oxidative Stress in Blood of Patients in Dependence of Community-Acquired Pneumonia Severity

Muravlyova, Larissa; Molotov-Luchankiy, Vilen; Bakirova, Ryszhan; Klyuyev, Dmitriy; Демидчик, Л. А.; Lee, Valentina

doi:10.3889/oamjms.2016.040

Cited by 11 publications

(18 citation statements)

References 20 publications

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“…They found that decreased serum TOS is associated with CAP. Muravlyova et al18 found that malondialdehyde and reactive carbonyl derivatives were significantly lower in CAP patients than in controls. Castillo et al14 showed that the antioxidant capacity of plasma, as well as glutathione and glutathione disulfide levels, were lower than in controls.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of dynamic thiol/disulfide redox state in community-acquired pneumonia

Parlak

Alışık

Hezer

et al. 2018

SMJ

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ObjectivesTo compare dynamic thiol/disulfide homeostasis between patients with community-acquired pneumonia (CAP) and healthy controls.MethodsThis prospective, case-control study was conducted in the Department of Pulmonary Diseases, Ankara Ataturk Training and Research Hospital, Yildirim Beyazit University, Ankara, Turkey, between August 2016 and August 2017. In total, 50 hospitalized patients with CAP and 35 healthy individuals were enrolled. Patients with comorbidities and smokers were excluded. The thiol/disulfide state was evaluated in each group. Thiol levels (native/total) and % polymorhonuclear leukocytes and C-reactive protein levels association were evaluated in patients with CAP.ResultsThere was no significant difference between the CAP and control groups in age or gender (both, p>0.05). The disulfide (SS) levels were similar between the 2 groups (p=0.148). The total thiol (TT) and native thiol (SH) levels were significantly lower (all, p=0.001) and the SS/TT levels were significantly higher (p=0.019) in the CAP group compared with the controls.ConclusionsThis study showed that the oxidant/antioxidant ratio was shifted to the oxidative side in CAP patients. An abnormal thiol/disulfide state may be an important factor in the pathogenesis and monitoring the treatment response. The thiol resources may use for treatment in CAP and may positively affect the prognosis.

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Section: Discussionmentioning

confidence: 97%

Evaluation of dynamic thiol/disulfide redox state in community-acquired pneumonia

Parlak

Alışık

Hezer

et al. 2018

SMJ

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“…[11][12][13][14][15] Several recent studies have evaluated the associations between CAP and the oxidant and antioxidant statuses. 9,10,16,17 Reactive oxygen species (ROS) occur normally in physiological conditions, and they are counterbalanced by oxidantantioxidant mechanisms. In CAP, these mechanisms are destroyed by phagocytes acting via the primary defense mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of dynamic thiol/disulfide homeostasis in adult patients with community-acquired pneumonia

Şener¹,

Çelik

Özhasenekler

et al. 2018

Hong Kong Journal of Emergency Medicine

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Background: Community-acquired pneumonia is an important cause of mortality and morbidity in all age groups. Oxidant and antioxidant mechanisms play an important role in the pathogenesis and mortality of community-acquired pneumonia. Objectives: In this study, the role of thiol/disulfide homeostasis in the diagnosis and prognosis of community-acquired pneumonia was investigated. Methods: This was a prospective, controlled, observational study involving 73 community-acquired pneumonia patients and 68 healthy volunteers. Results: The native thiol and total thiol, which are thiol/disulfide homeostasis components, were significantly lower in the community-acquired pneumonia group. It was also found that the native thiol was lower in the high-risk community-acquired pneumonia group and that the native thiol and total thiol were associated with the Pneumonia Severity Index, CRB65 (confusion, respiratory rate, blood pressure, ⩾65 years old), and CURB65 (confusion, uremia, respiratory rate, blood pressure, ⩾65 years old) scores. The thiol compound levels were also associated with the C-reactive protein and procalcitonin levels. However, there was no significant difference between the survivors and non-survivors in terms of the thiol/disulfide homeostasis parameters. Conclusion: This study demonstrated the important role that oxidative stress plays in the pathogenesis of community-acquired pneumonia. The thiol/disulfide homeostasis biomarkers especially the native thiol and index-1 levels were significantly lower in patients with community-acquired pneumonia. Further studies are needed to investigate the diagnostic and prognostic value of thiol/disulfide homeostasis parameters in community-acquired pneumonia.

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“…Thus, neutrophils play a dual role: on the one hand, they perform a protective function; on the other, they are potential mediators of tissue damage. A sufficient number of studies have been devoted to the study of indices of oxidative stress in the blood to assess the severity of the pathological process, but the number of studies of indices of oxidative stress of neutrophils in CAP patients with chronic obstructive pulmonary disease (COPD) and patients with CAP depending on the degree of disease severity is limited [ 6 , 7 ]. In this aspect, the study of neutrophils and their functional and metabolic status is one of the most urgent and promising tasks, since their condition largely determines the development and outcomes of the disease.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia

et al. 2020

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Background and Objectives. Community-acquired pneumonia (CAP) has a high mortality rate among adult patients throughout the world. The highest mortality is registered in the older age group with a steady increase in the number of cases of morbidity among persons of working age. Neutrophils are one of the most urgent areas of research, since their condition largely determines the development and outcome of acute pneumonia. We study the indices of oxidative stress and oxidized-modified proteins of neutrophils in CAP patients, depending on the degree of severity, and also compare the detection frequency of neutrophil extracellular traps in the progression of pneumonia. Materials and Methods. 51 patients with CAP were divided into 2 groups depending on the severity of the pathological process. The first group (I) consisted of 32 patients with moderate severity of pneumonia. The second group (II) consisted of 19 patients with severe pneumonia. The third group (III), the comparison group, consisted of 14 CAP patients with chronic obstructive pulmonary disease (COPD). The control group consisted of 19 volunteers. Results. Statistically significant increase in the level of carbonyl derivatives (CD) in patients of all study groups relative to the control group was revealed. In the group of patients with moderate severity and severe pneumonia, also in CAP patients with COPD, the level of CD exceeded the control group. There was no statistically significant difference in the level of advanced oxidation protein products (AOPP) and myeloperoxidase (MPO) in blood neutrophils between the studied groups. Conclusion. Results indicate an oxidative imbalance in neutrophils and contribute to the worsening of the course of the disease.

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Characteristic of the Oxidative Stress in Blood of Patients in Dependence of Community-Acquired Pneumonia Severity

Cited by 11 publications

References 20 publications

Evaluation of dynamic thiol/disulfide redox state in community-acquired pneumonia

Evaluation of dynamic thiol/disulfide redox state in community-acquired pneumonia

Evaluation of dynamic thiol/disulfide homeostasis in adult patients with community-acquired pneumonia

Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia

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