“…3 As with NSAIDs, disruption of the balance of the lining of the gastric mucosa occurs in several ways; decreased mucus production as a factor in gastric protection, disruption of gastric acid production, and inhibition of COX-1, which causes vasoconstriction so that vascularity is not optimal which can cause necrosis of epithelial cells. 6 Meanwhile, based on surgery reports, the perforations are mostly located in 1-5 cm prepylorus. According to its anatomical location, the stomach is divided into several parts, ranging from cardia, fundus, corpus, antrum, and pylorus.…”