Characteristic Generated Alterations of Autoantibody Patterns in Idiopathic Thrombocytopenic Purpura

Sundblad, Anne; Ferreira, C.; Nóbrega, Alberto; Haury, Matthias; Ferreira, Eliane de Oliveira; Pádua, Fernando de; Coutinho, António

doi:10.1006/jaut.1996.0116

Cited by 17 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In AITP, as in many other autoimmune diseases, there is no direct relationship between the presence, titre and characteristics of autoantibodies and the clinical course or severity of the disease [27][28][29]. Experimental studies and theoretical models have shown that there are general, but disease-specific alterations of the antibody repertoire in serum from patients with autoimmune diseases, including AITP [30,31]. Such alterations might already be present in an early stage of the disease, before clinical symptoms occur, but the underlying cellular mechanism is not known.…”

Section: Introductionmentioning

confidence: 97%

Increased Utilization of the VH6 Gene Family in Patients with Autoimmune Idiopathic Thrombocytopenic Purpura

Dijk-Härd

Feld

Holmberg

et al. 1999

Journal of Autoimmunity

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 97%

Increased Utilization of the VH6 Gene Family in Patients with Autoimmune Idiopathic Thrombocytopenic Purpura

Dijk-Härd

Feld

Holmberg

et al. 1999

Journal of Autoimmunity

View full text Add to dashboard Cite

“…Thus, the presence of antiplatelet Abs appears to be a common feature of many autoimmune conditions, and the etiology of the immune thrombocytopenia cannot be differentiated on the grounds of this Ab specificity. Moreover, other serum Ab reactivities have been suggested in order to differentiate ITP from other autoimmune diseases and controls, as ITP donors had shared characteristic alterations in serum Ab reactivity patterns on homologous erythrocyte and liver antigens which were different from those of systemic lupus erythematosus patients and normal controls [15]. With respect to the pathogenic role of serum Abs against platelet GPs, Fujisawa et al [16] reported about 13 of 21 plasma Abs tested from patients with ITP that bound primarily to the carboxyterminus of GP IIIa, which is relatively inaccessible on the surface of intact platelets when compared with other epitopes.…”

Section: Figmentioning

confidence: 99%

Autoantibody Level Modification in Adult Patients with Idiopathic Thrombocytopenic Purpura following Intravenous Immunoglobulin Treatment

Levy

Sherer²,

Ahmed³

et al. 1998

Nat Immun

View full text Add to dashboard Cite

The aim of this study was to determine whether treatment of patients with immune thrombocytopenic purpura (ITP) with intravenous immunoglobulin (IVIg) is associated with a modification in the antiplatelet glycoprotein (GP) antibodies (Abs). Fourteen patients with ITP (11 females and 3 males, mean age 36.6 years, range 18–72) received one to four IVIg treatment courses. The preparation used was ISIVEN that was given in a dose of 2 g/kg body weight in a 5-day schedule and in monthly intervals. Levels of IgG, IgM and IgA isotypes of Abs to GPs IIb/IIIa and Ib/IX were measured before the treatment, and before and after each treatment course. Two patients did not respond to IVIg, 6 had a temporary response, 5 had a sustained response and 1 patient responded well to the treatment but was lost to follow-up. The patients had a high prevalence of serum Abs directed against GPs IIb/IIIa and Ib/IX before the treatment, and the mean IgG isotype levels of both Abs increased after each treatment course, and decreased again before the following course began. Whenever high Ab levels of either isotype (>10 U/ml) were detected before the treatment, they were significantly decreased before the last treatment course. The elevated levels of IgG Abs to IIb/IIIa and Ib/IX after every course are probably a result of displacement of these Abs from Fc receptors by the IVIg, rather than of exogenous infusion of these Abs contained within the IVIg, whereas the decrease in high Ab levels after a few treatment courses results from the immunomodulatory effects of IVIg: suppression of Ab formation, and the presence of anti-idiotypes.

show abstract

“…There is a fourth important aspect: Panama blots undergo significant and characteristic changes during severe alterations of immunological activities, such as human autoimmune diseases (41)(42)(43). More recently, changes in Panama blot profiles against autologous organs and/or E. coli extracts were correlated with clinical forms of chronic parasitic diseases, such as trypanosomiasis cruzi, malaria and schistosomiasis mansoni, both in humans and in mice (4,5,44).…”

Section: Panama Blotsmentioning

confidence: 99%

“…Aberrant patterns of connectivity of the immune system are associated with autoimmune diseases, in which significant changes in the pattern of immu-noglobulin formation occur (41)(42)(43). When von Pirquet and Schick characterized serum sickness , they showed that immunological activities, of themselves, are not always defensive and may be damaging to the organism (47).…”

Section: The Emergence Of Pathologymentioning

confidence: 99%

“…The physiology of the immune system is conservative and maintains steady states of lymphocyte activation and differentiation acquired early in ontogenesis, influenced but not determined by maternal and early environmental factors, as revealed by the ontogeny of patterns of natural IgM reactivity with complex antigenic mixtures (40)(41)(42)(43). We propose that clonal expansions occurring during infectious, allergic and autoimmune diseases are elements inherent to the pathology of these conditions, which may be better described as deviations from normal dynamics than as defensive reactions.…”

Section: Codamentioning

confidence: 99%

See 1 more Smart Citation

The conservative physiology of the immune system

Vaz

Faria

Verdolin

et al. 2003

Braz J Med Biol Res

View full text Add to dashboard Cite

Current immunological opinion disdains the necessity to define global interconnections between lymphocytes and regards natural autoantibodies and autoreactive T cells as intrinsically pathogenic. Immunological theories address the recognition of foreignness by independent clones of lymphocytes, not the relations among lymphocytes or between lymphocytes and the organism. However, although extremely variable in cellular/molecular composition, the immune system preserves as invariant a set of essential relations among its components and constantly enacts contacts with the organism of which it is a component. These invariant relations are reflected, for example, in the life-long stability of profiles of reactivity of immunoglobulins formed by normal organisms (natural antibodies). Oral contacts with dietary proteins and the intestinal microbiota also result in steady states that lack the progressive quality of secondary-type reactivity. Autoreactivity (natural autoantibody and autoreactive T cell formation) is also stable and lacks the progressive quality of clonal expansion. Specific immune responses, currently regarded as the fundament of the operation of the immune system, may actually result from transient interruptions in this stable connectivity among lymphocytes. More permanent deficits in interconnectivity result in oligoclonal expansions of T lymphocytes, as seen in Omenn s syndrome and in the experimental transplantation of a suboptimal diversity of syngeneic T cells to immunodeficient hosts, which also have pathogenic consequences. Contrary to theories that forbid autoreactivity as potentially pathogenic, the physiology of the immune system is conservative and autoreactive. Pathology derives from failures of these conservative mechanisms.

show abstract

Characteristic Generated Alterations of Autoantibody Patterns in Idiopathic Thrombocytopenic Purpura

Cited by 17 publications

References 0 publications

Increased Utilization of the VH6 Gene Family in Patients with Autoimmune Idiopathic Thrombocytopenic Purpura

Increased Utilization of the VH6 Gene Family in Patients with Autoimmune Idiopathic Thrombocytopenic Purpura

Autoantibody Level Modification in Adult Patients with Idiopathic Thrombocytopenic Purpura following Intravenous Immunoglobulin Treatment

The conservative physiology of the immune system

Contact Info

Product

Resources

About