Characteristic Features of Wound Healing in Laser-Induced Incisions

Schünke, Michael; Krüss, C.; Mecke, H.; Werner, Jochen A.

doi:10.1159/000424328

Cited by 10 publications

(9 citation statements)

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“…Nd:YAG laser coagulation in other tissues typically causes dispersed changes over time spreading over about 8 mm (Schirk et al, 1994;Schunke et al, 1995;Lippert et al, 1995). This is usually called 'collateral damage', meaning the tissue effects spread far beyond what is seen at the time of surgery.…”

Section: Discussionmentioning

confidence: 99%

Time-related cotyledonary effects of laser coagulation of superficial chorionic vessels in an ovine model

et al. 1999

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Endoscopic Nd:YAG laser coagulation of superficial chorionic plate vessels has been suggested as a ‘causal’ therapy for severe twin‐to‐twin transfusion syndrome (TTS), as it is believed to arrest flow over vascular anastomoses. The therapy remains debated, partly because it is questioned whether coagulation of superficial chorionic vessels can arrest blood flow over deeply located anastomoses. The latter are believed to be responsible for the majority of cases of severe TTs. In this study, the coagulation performance, and the immediate and delayed tissue effects of laser coagulation were evaluated in an in vivo ovine model. Eight pregnant ewes of about 100 days' gestational age (term=145 days) were studied. In utero coagulation was done through a 1·2mm fetoscope loaded with a 600μm laser fibre, connected to an Nd:YAG laser in continuous mode. Superficial cotyledonary vessels were coagulated under visual control at a distance of 1cm with a mean power of 60 watts. 31 lasered cotyledons were harvested, either immediately (n=15), 14 days (n=8) or 42 days (n=8) after the surgery and evaluated by inspection and histology. Control cotyledons were either neighbouring cotyledons from the same amniotic sac (internal control) or cotyledons from another gestational‐age‐matched sac (external control). Immediate effects consisted of localized coagulation necrosis at the zone of laser impact with no significant histological effect at more than 2mm distance, except tissue congestion. Long‐term effects consisted of fibrosis without any vascular recanalization or tissue regeneration extending from the impact site over the whole cotyledon. All treated cotyledons underwent complete infarction over time. This study provides experimental evidence supporting that laser coagulation of superficial chorionic vessels entering a cotyledon achieves complete functional elimination of the involved cotyledon. Copyright © 1999 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Time-related cotyledonary effects of laser coagulation of superficial chorionic vessels in an ovine model

et al. 1999

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“…These wounds take longer to heal than those created with a scalpel. 23 The effectiveness of surgery, therefore, should be assessed months later, when the healing process has stabilized. Indeed, a study on the long-term histopathologic changes after LAUP disclosed that the various components of the soft palate underwent extensive changes, with replacement of the loose connective tissue in the lamina propria by diffuse fibrosis that also extended to the central layer, on the expanse of seromucous glands and muscle fibers.…”

Section: Commentmentioning

confidence: 99%

Is There a Better Way to Do Laser-Assisted Uvulopalatoplasty?

Berger¹,

Stein²,

Ophir³

et al. 2003

Arch Otolaryngol Head Neck Surg

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“…These wounds take longer to heal than those created with a scalpel. 20 The effectiveness of surgery, therefore, should be assessed months later, when the healing process has stabilized. Indeed, Berger et al 9 have recently reported the long-term histopathologic changes after LAUP.…”

Section: Commentmentioning

confidence: 99%

Laser-Assisted Uvulopalatoplasty for Snoring

Berger¹,

Finkelstein²,

Stein³

et al. 2001

Arch Otolaryngol Head Neck Surg

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The favorable subjective short-term results of laser-assisted uvulopalatoplasty deteriorated with time. In addition, postoperative nocturnal polysomnography showed that the procedure caused mild obstructive sleep apnea in a considerable number of patients who formerly were nonapneic snorers. These findings may be related to velopharyngeal narrowing and progressive palatal fibrosis, caused by the thermal damage inflicted by the laser beam.

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Characteristic Features of Wound Healing in Laser-Induced Incisions

Cited by 10 publications

References 0 publications

Time-related cotyledonary effects of laser coagulation of superficial chorionic vessels in an ovine model

Time-related cotyledonary effects of laser coagulation of superficial chorionic vessels in an ovine model

Is There a Better Way to Do Laser-Assisted Uvulopalatoplasty?

Laser-Assisted Uvulopalatoplasty for Snoring

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