Characteristic extrinsic Cotton effects of azo proteins

Gf, Fairclough; Bl, Vallee

doi:10.1021/bi00823a009

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1971

1975

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Cited by 22 publications

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Reaction of diazonium salt with tyrosine residues in polypeptides

Pieroni¹,

Fissi²,

Houben³

1975

Makromol. Chem.

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Some copolymers of L-glutamic acid and L-tyrosine are treated with p-carboxybenzenediazonium chloride. Monoazotyrosine chromophores can be obtained along the polypeptide chains in the presence of a stoichiometric quantity of the reagent, whereas an excess of the reagent gives rise to the formation of a mixture of mono-and bis-azoderivatives. In all the cases only a part of the total number of the tyrosine residues can be modified. The results are discussed on the basis of the pK, values for the ionization of tyrosine and azo-tyrosine OH-groups. ZUSAMMENFASS UNG:Einige Copolymere aus L-Glutaminsiiure und L-Tyrosin werden mit p-Carboxybenzoldiazoniumchlorid behandelt. Durch eine stochiometrische Reagensmenge werden Monoazo-tyrosin-Chromophore in den Polypeptid-Ketten gebildet, wahrend ein Reagensuber-schul3 zur Bildung einer Mischung von Mono-und Bisazoderivaten fuhrt. In allen Fallen kann nur ein Teil der Tyrosin-Grundbausteine verandert werden. Die Ergebnisse werden mit den verschiedenen pK,-Werten fur die Ionisierung der OH-Gruppen in den Tyrosin-und Azotyrosin-Grundbausteinen erklart.

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