Characteristic Cutaneous Lesions in Patients With Brucellosis

Ariza, Javier; Servitje, Octavio; Pallarés, Román; Viladrich, Pedro F.; Rufí, Gabriel; Peyrı́, Jordi; Gudiol, Francisco

doi:10.1001/archderm.1989.01670150070010

Cited by 71 publications

(89 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Three cases of human brucellosis have been reported associated with B. melitensis infection of breast implant patients. These involved patients who had either consumed unpasteurized cheese or sniffed B. melitensis cultures in a clinical laboratory (1,3,20,31).…”

mentioning

confidence: 99%

Novel Brucella Strain (BO1) Associated with a Prosthetic Breast Implant Infection

Stauffer

Koylass

et al. 2008

J Clin Microbiol

View full text Add to dashboard Cite

We report the microbiological, biochemical, and molecular characterization of an unusual Brucella strain (BO1) isolated from a breast implant wound in a 71-year-old woman with clinical symptoms consistent with brucellosis. Initial phenotypic analysis, including biochemical and antimicrobial susceptibility testing, cellular fatty acid analysis, and molecular analysis based on DNA-DNA reassociation and the presence of multiple copies of IS711 element suggested that the isolate was a Brucella-like organism, but species determination using microbiological algorithms was unsuccessful. Furthermore, molecular data based on 16S rRNA gene sequencing and multilocus sequence analysis demonstrated that BO1 was an unusual Brucella strain and not closely related to any currently described Brucella species. However, comparison with equivalent sequences in Ochrobactrum spp. confirms that the isolate is much more closely related to Brucella than to Ochrobactrum spp., and thus the isolate likely represents an atypical and novel strain within the genus Brucella.Brucellosis is primarily a zoonotic disease caused by members of the genus Brucella, which consists of six recognized species based on pathogenicity and host preferences: Brucella abortus (cattle), Brucella canis (dogs), Brucella melitensis (goats or sheep), Brucella suis (swine), Brucella ovis (rams), and Brucella neotomae (desert rats), as well as recently identified strains from marine mammals (5,10,13,26,34). Early studies on genomic DNA hybridization demonstrate a high degree of homology among the brucellae (40) and thus suggest the genus Brucella as one species, Brucella melitensis with several biovars (14), which has been confirmed by a number of molecular approaches, including 16S rRNA gene sequencing (21), multilocus enzyme electrophoresis (19), and whole-genome sequence analyses (15,24,36). However, because of the lack of widespread support the Brucella Taxonomy Subcommittee has recently returned to the traditional classification of the six Brucella nomenspecies with recognized biovars, along with two presumptive Brucella spp. from marine mammals: B. cetaceae and B. pinnipediae (34). Brucellae are intracellular facultative pathogens that infect many organs and soft tissues, including mammary glands, and frequently result in abortion, low milk production, and fetal death in animals (12,45).Most human disease is caused by B. abortus, B. suis, B. melitensis, and B. canis (13,22,35) and is most frequently associated with the consumption of unpasteurized dairy products or direct contact with infected animals or animal products (38,46). Brucellosis is also an occupational hazard of laboratory scientists infected by the inhalation of aerosols in a microbiology laboratory setting (32, 37). In humans, brucellosis is a systemic, febrile illness and can be associated with chronic debilitating infection of major organ systems that may include bone and the kidney, brain, epididymis, liver, ovary, and gallbladder (7,8,18,27). However, association of Brucella with infection of m...

show abstract

mentioning

confidence: 99%

Novel Brucella Strain (BO1) Associated with a Prosthetic Breast Implant Infection

Stauffer

Koylass

et al. 2008

J Clin Microbiol

View full text Add to dashboard Cite

show abstract

“…The same or similar skin lesion patterns are associated with numerous dermatological entities other than brucellosis. The unspecificity of etiologic factor/-s causing the same type of skin lesion, confirm the historical statement that "Brucellosis is a Great Imitator" [4,7]. The list of differential diagnoses is practically endless [8][9][10].…”

Section: Introductionmentioning

confidence: 61%

“…In the 1950s, brucellosis was proposed as one of the first "causes" of the "chronic fatigue syndrome" (CFS). rarely been reported (3.8% -17%) in different published studies [4][5][6][7]. A large variety of skin manifestations are associated with brucellosis.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Manifestations of Brucellosis

Balabanova-Stefanova¹,

Starova²,

Arsovska-Bezhoska³

2010

Macedonian Journal of Medical Sciences

View full text Add to dashboard Cite

Aim.To present and compare 10-year clinical experience of human brucellosis in Republic of Macedonia with data presented in the literature about the frequency of cutaneous manifestations of brucellosis. To estimate the percent of underdiagnosed / misdiagnosed skin lesions related to brucellosis and to raise awareness of cutaneous manifestations of brucellosis in our clinical practice. Methods.Clinical records and experience of the Infectious Diseases Clinic and Dermatology Clinic, Faculty of Medicine, Skopje, and a review of the recent literature data about cutaneous manifestations of brucellosis relevant for dermatologists, infectologists and general practitioners. Results.Cutaneous manifestations or complications have been reported rarely, less than 5% (3.8 % -17 %) in different published studies. A variety of skin lesions have been reported in patients with brucellosis, including rashes (25%), nodules, papules, erythema nodosum (25%), eczematous lesions (12.5%), psoriasiform lesions (12.5%), petechiae, purpura and others.

show abstract

“…The cutaneous manifestations of brucellosis may develop due to direct inoculation, hypersensitivity phenomena, deposition of immune complexes, and direct invasion of the skin or via a hematogenous route of spread by the organism [5–7]. The cutaneous manifestations in brucellosis may be encountered as erythema, papules, petechiae, urticaria, impetigo, eczematous rash, erythema nodosum, subcutaneous abscess, and cutaneous vasculitis [1, 2].…”

Section: Discussionmentioning

confidence: 99%

“…In the study performed by Ariza et al and investigating 436 patients of brucellosis, the authors determined the most commonly observed cutaneous lesions to be disseminated violet erythematous, papulonodular eruption, and erythema nodosum-like lesions and they reported that these lesions were seen in about 6% of the patients [5]. In the study performed by Akcali et al and investigating 140 patients of brucellosis, the authors determined skin involvements associated with brucellosis in a total of 8 patients (5,7%) as follows: 2 maculopapular eruptions, 2 erythema nodosum-like lesions, 1 psoriasiform lesion, 1 palmar erythema, 1 malar eruption, and 1 palmar eczema [8].…”

Section: Discussionmentioning

confidence: 99%

A Case of Brucellosis with Recurrent Attacks of Vasculitis

Korkmaz

Kıdır

Namdar

et al. 2016

Case Reports in Infectious Diseases

View full text Add to dashboard Cite

Brucellosis is a zoonosis that affects several organs or systems. Skin involvement is nonspecific and it is reported to range between 0,4 and 17% of the patients with brucellosis. Here, we defined a 36-year-old female patient presented to our clinic with a clinical picture of recurrent attacks of vasculitis due to brucellosis for the first time. Skin involvement and vasculitic lesions as a finding of skin involvement are nonspecific in brucellosis. Therefore, in the regions like Turkey where brucellosis is endemic, brucellosis should be kept in mind necessarily in the differential diagnosis of vasculitis.

show abstract

Characteristic Cutaneous Lesions in Patients With Brucellosis

Cited by 71 publications

References 14 publications

Novel Brucella Strain (BO1) Associated with a Prosthetic Breast Implant Infection

Novel Brucella Strain (BO1) Associated with a Prosthetic Breast Implant Infection

Cutaneous Manifestations of Brucellosis

A Case of Brucellosis with Recurrent Attacks of Vasculitis

Contact Info

Product

Resources

About