Characteristic Complications after Autologous Chondrocyte Implantation for Cartilage Defects of the Knee Joint

Niemeyer, Philipp; Pestka, Jan M.; Kreuz, Peter; Erggelet, Christoph; Schmal, Hagen; Suedkamp, Norbert P.; Steinwachs, Matthias

doi:10.1177/0363546508322131

Cited by 236 publications

(243 citation statements)

References 31 publications

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“…17 The periosteal flap cover was made responsible for the hypertrophy in p-ACI. The occurrence of GH using the mb-ACI method and its clinical relevance are still uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…The IKDC and VAS scores used in this study are established and validated scores in the follow-up examination of cartilage regeneration procedures and show a high rate of reliability and reproduction, 11,22 hence the frequent use of these scores in follow-up examinations after p-ACI and mb-ACI. 9,14,17,18,21 Magnetic Resonance Imaging A follow-up magnetic resonance imaging (MRI) examination was performed after 3, 6, 12, and 24 months using a 1.5-T machine (Magnetom Sonata, Fa Siemens AG, Erlangen, Germany) with the use of a commercially available circular polarizing 1-channel knee spool in a predetermined protocol. Fast spin echo (dual T2-FSE) and fat saturation gradient echo (3D-GE-FS) sequences were produced.…”

Section: Clinical Scoresmentioning

confidence: 99%

“…The clinical results of the mb-ACI are comparable with those of the classic ACI. 1,4,9,17 Because the periosteal cover of the defect is not applicable using the mb-ACI technique, we have assumed that the rate of GH is smaller than after p-ACI.…”

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confidence: 99%

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The Incidence and Clinical Relevance of Graft Hypertrophy After Matrix-Based Autologous Chondrocyte Implantation

et al. 2011

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Background: Graft hypertrophy is the most common complication of periosteal autologous chondrocyte implantation (p-ACI). Purpose: The aim of this prospective study was to analyze the development, the incidence rate, and the persistence of graft hypertrophy after matrix-based autologous chondrocyte implantation (mb-ACI) in the knee joint within a 2-year postoperative course. Study Design: Case series; Level of evidence, 4. Methods: Between 2004 and 2007, a total of 41 patients with 44 isolated cartilage defects of the knee were treated with the mb-ACI technique. The mean age of the patients was 35.8 years (standard deviation [SD], 11.3 years), and the mean body mass index was 25.9 (SD, 4.2; range, 19-35.3). The cartilage defects were arthroscopically classified as Outerbridge grades III and IV. The mean area of the cartilage defect measured 6.14 cm2 (SD, 2.3 cm2). Postoperative clinical and magnetic resonance imaging (MRI) examinations were conducted at 3, 6, 12, and 24 months to analyze the incidence and course of the graft. Results: Graft hypertrophy developed in 25% of the patients treated with mb-ACI within a postoperative course of 1 year; 16% of the patients developed hypertrophy grade 2, and 9% developed hypertrophy grade 1. Graft hypertrophy occurred primarily in the first 12 months and regressed in most cases within 2 years. The International Knee Documentation Committee (IKDC) and visual analog scale (VAS) scores improved during the postoperative follow-up time of 2 years. There was no difference between the clinical results regarding the IKDC and VAS pain scores and the presence of graft hypertrophy. Conclusion: The mb-ACI technique does not lead to graft hypertrophy requiring treatment as opposed to classic p-ACI. The frequency of occurrence of graft hypertrophy after p-ACI and mb-ACI is comparable. Graft hypertrophy can be considered as a temporary excessive growth of regenerative cartilage tissue rather than a true graft hypertrophy. It is therefore usually not a persistent or systematic complication in the treatment of circumscribed cartilage defects with mb-ACI.

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“…17 The periosteal flap cover was made responsible for the hypertrophy in p-ACI. The occurrence of GH using the mb-ACI method and its clinical relevance are still uncertain.…”

Section: Discussionmentioning

confidence: 99%

Section: Clinical Scoresmentioning

confidence: 99%

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The Incidence and Clinical Relevance of Graft Hypertrophy After Matrix-Based Autologous Chondrocyte Implantation

et al. 2011

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“…By using matrix-associated ACI, the revision rate could be reduced compared to the periosteal covered ACI. 72 As described earlier, complications like graft hypertrophy related to the periosteal flap or insufficient regenerative cartilage related to restricted function of the injected chondrocytes were addressed by the matrix-associated technique. 35 By the development of the matrix-guided technique, the complexity and morbidity of the procedure could be reduced.…”

Section: Developments In Acimentioning

confidence: 99%

Autologous chondrocyte implantation for cartilage repair: current perspectives

Zellner¹,

Krutsch²,

Pfeifer³

et al. 2015

ORR

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Over the last decade, regenerative treatment options have become the more routinely used techniques for treatment of cartilage defects, with predictable outcomes for their specific indications. For large chondral lesions in young patients, in particular, autologous chondrocyte implantation is the treatment of choice for restoration of joint health. This review focuses on indications, results, and outcome predictors of autologous chondrocyte implantation in comparison to other regenerative treatment procedures and discusses improvement options and future perspectives for autologous chondrocyte transplantation. As research activities are increasing in the field of regenerative joint therapy, recent developments may help to overcome remaining limitations step by step.

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“…In recent years, matrix-induced autologous chondrocyte implantation has successfully been used in animal models [13] and even in clinical trials [14] . However, mentioned technique is timeconsuming and implicates the risk of potential donorsite morbidity because of chondrocyte harvesting [15,16] . Collagen-based materials have been already used for cartilage repair in rabbits with satisfying findings [17,18] .…”

Section: Introductionmentioning

confidence: 99%

Tavşanlarda Artikular Kartilaj Defekt Onarımında Devekuşu Plantar Ligament Kökenli Hücre İçermeyen Matriks Doku Kullanımı

Moridpour¹,

Fattahian²,

Mortazavi³

2017

Kafkas Univ Vet Fak Derg

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Citation of This ArticleMoridpour R, Fattahian HR, Mortazavi P: Using cell-free matrix derived from ostrich plantar ligament for repair of articular cartilage defect of rabbit. Kafkas Univ Vet Fak Derg, 23 (5): 707-713, 2017. DOI: 10.9775/kvfd.2017 Abstract Articular cartilage lesions are most common injury of the knee for which several repair methods have been described. We described in-vivo potential of collagen type I scaffold extracted fromknee of ostrich. Full thickness defects were created bilaterally in the weight bearing area of femoral condyles of the both femurs of 7 white New zealand adult male rabbits weighting 1800±100 g. The six left medial condyles as experimental group I were filled by using cell-free tissue and six right medial condyles of the same rabbit were treated by cell-tissue as experimental group II and the right medial condyle defect of one rabbit as control group was left without treatment. Histopathology data demonstrated significant difference between three groups with respect to the cartilage repair indicators as the morphology of the cells, color matrix and cartilage thickness (P<0.05). Furthermore, sub-chondral bone formation showed a significant difference and relationship between two experimental groups and control group (P<0.05). The use of cell-free ligamentum plantar matrix showed markedly significant improvement in the processes of joint cartilage repair compared control group (P<0.05). Results support the use of cell-free ligamentum plantar can be useful and promising bio-engineering procedure as a scaffold for the treatment of the articular cartilage surface. Keywords: Cell-free matrix, Ostrich plantar ligament, Repair, Articular cartilage defect, Rabbit Tavşanlarda Artikular Kartilaj Defekt Onarımında Devekuşu Plantar Ligament Kökenli Hücre İçermeyen Matriks Doku Kullanımı ÖzetArtikular kartilaj lezyonları dizin en sıklıkla gözlenen yaralanması olup birkaç onarım metodu tanımlanmıştır. Bu çalışmada devekuşunun dizinden ekstrakte edilen kollajen tip I doku iskelesinin in vivo potansiyeli tanımlanmıştır. Ağırlıkları 1800±100 g olan 7 adet Yeni Zelanda ergin erkek tavşanın her iki femurunda femoral kondulusların ağırlık taşıyan bölgelerinde bilateral olarak tüm kat hasarı oluşturuldu. Altı sol medial kondulus hücre içermeyen doku ile doldurulurken (Grup I) aynı tavşanların altı sağ medial kondulus hasarı hücre içeren doku ile tedavi edildi (Grup II) ve bir tavşanın sağ medial kondulus hasarı tedavi uygulanmayarak kontrol grubu olarak bırakıldı. Histopatoloji bulguları kartilaj onarım belirteçleri olarak hücre morfolojisi, renk matriks ve kartilaj kalınlığı bakımlarından her üç grup arasında anlamlı derecede fark olduğunu gösterdi (P<0.05). Ayrıca, subkondral kemik oluşumu iki deney grubu ile kontrol grubu arasında anlamlı derecede fark olduğunu göstermiştir (P<0.05). Hücre içermeyen ligamentum plantar matriks kullanımının kontrol grubu ile karşılaştırıldığında eklem kartilaj onarımında belirgin derecede iyileşme oluşturduğu gözlemlendi (P<0.05). Elde edilen sonuçlar hücre iç...

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Characteristic Complications after Autologous Chondrocyte Implantation for Cartilage Defects of the Knee Joint

Cited by 236 publications

References 31 publications

The Incidence and Clinical Relevance of Graft Hypertrophy After Matrix-Based Autologous Chondrocyte Implantation

The Incidence and Clinical Relevance of Graft Hypertrophy After Matrix-Based Autologous Chondrocyte Implantation

Autologous chondrocyte implantation for cartilage repair: current perspectives

Tavşanlarda Artikular Kartilaj Defekt Onarımında Devekuşu Plantar Ligament Kökenli Hücre İçermeyen Matriks Doku Kullanımı

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