Characteristic [Beta]-Globin Gene Cluster Haplotypes of Evenkis and Oroqens in North China

Shimizu, Kōji; Marubayashi, Azusa; Tokimasa, Kozue; Harihara, Shinji; Omoto, Keiichi; Imanishi, Tadashi; Hao, Luping; Jin, Feng

doi:10.1353/hub.2005.0009

Cited by 7 publications

(11 citation statements)

References 28 publications

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“…Haplotypes are combinations of 5 0 subhaplotypes (combinations of + or -at the five restriction sites 5 0 to the d-globin gene) and 3 0 subhaplotypes (combinations of + or -at the two restriction sites in and 3 0 to the b-globin gene) (Shimizu et al 2004), and they were estimated by the EH program of Ott (2003). Pairwise linkage disequilibrium (LD) of D 0 between seven pairwise RFLP sites was calculated according to the method of Lewontin (1964).…”

Section: Rflps and Haplotype Estimationmentioning

confidence: 99%

“…Although the resolving power of the frequency distribution analysis of the b-globin gene cluster haplotypes may be inferior to that using the combination of mtDNA and Y-chromosome haplogroups, the former study using nuclear DNA polymorphisms to analyze the genetic relationships between human populations is also useful (Shimizu et al 2004). The present study analyzed the characteristics of the b-globin gene cluster haplotypes in Han Chinese at Beijing, Xi'an, and Kunming and showed their mutual genetic relationships and also their genetic affinities for other Asians.…”

Section: Introductionmentioning

confidence: 99%

“…-Globin gene diversity analysis based on haplotype frequency distribution in some populations Data from Mexican mestizos, Cypriots, Sicilians, Algerians, Asian Indians, Samoans, Cambodians, Thais, South Chinese(Shimizu et al 2001), Koreans, Japanese, three Colombian Amerindians, Evenkis, Oroqens(Shimizu et al 2004), Khalkhs, Buryats(Shimizu et al 2006), and three Han Chinese (present study) b Data from Cypriots and Sicilians c Data from three Colombian Amerindians d Data from Cambodians, Thais, South Chinese, Evenkis, Oroqens, Khalkhs, Buryats, Koreans, Japanese, and three Han Chinese e Data from Cambodians and Thais f Data from Khalkhs, Buryats, Evenkis, and Oroqens g Data from Koreans and Japanese h Data from three Han Chinese and South Chinese i Data from Han Chinese at Beijing and Xi'an j Data from Han Chinese at Kunming and South Chinese…”

mentioning

confidence: 99%

“…The haplotype frequency distribution has been analyzed much less frequently than the 5 0 subhaplotype frequency distribution, but the former is more useful for genetic study than the latter (Shimizu et al 2004(Shimizu et al , 2006.…”

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Characteristics of the β-Globin Gene Cluster Haplotypes of Three Han Chinese Populations at Beijing, Xi’an, and Kunming as Compared with Those of Other Asian Populations

et al. 2008

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Haplotype frequencies of the beta-globin gene cluster of Han Chinese at Beijing, Xi'an, and Kunming were estimated, and their mutual genetic relationships were examined and compared to those of Buryats, Khalkhs, Evenkis, Oroqens, Koreans, and Colombian Amerindians. A major 5' subhaplotype (5' to the delta-globin gene), a major 3' subhaplotype (in and 3' to the beta-globin gene), and a major haplotype (combination of 5' and 3' subhaplotypes) are represented as + - - - -, - +, and + - - - - - +, respectively, and found in all three Han Chinese. A rare 5' subhaplotype, - - - - -, which is one of the possible ancestral types, was found only in Han Chinese at Kunming at low frequency (0.013), and a rare 3' subhaplotype, - -, was also observed in all three Han Chinese at low frequencies (0.009-0.014). The present haplotype frequency study suggested that the highest genetic affinity was found between Han Chinese at Beijing and those at Xi'an; the next highest was between Han Chinese at Beijing and Koreans, followed by that between Han Chinese at Beijing and Khalkhs, then that between Han Chinese at Xi'an and those at Kunming or Khalkhs, and finally that between Han Chinese at Beijing and those at Kunming. A genetic boundary between northern and southern Han Chinese was not evident in the present study.

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Section: Rflps and Haplotype Estimationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Characteristics of the β-Globin Gene Cluster Haplotypes of Three Han Chinese Populations at Beijing, Xi’an, and Kunming as Compared with Those of Other Asian Populations

et al. 2008

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“…The distinct advantage of the β-globin gene cluster approach is that different populations from different studies are easily comparable since the same restriction sites and haplotypes have been widely used. Although many studies using the β-globin gene cluster haplotype have been carried out in a variety of populations in Africa, Europe, America and Asia, only a few northern Chinese ethnic populations have been analyzed 13 14 . In spite of their important roles in origin, migration and evolutionary history of Chinese ethnic populations, a large number of southwestern Chinese minority populations have not been investigated for β-globin gene cluster characteristics and haplotype variation.…”

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β-globin gene cluster haplotypes in ethnic minority populations of southwest China

Sun

Liu

Huang

et al. 2017

Sci Rep

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The genetic diversity and relationships among ethnic minority populations of southwest China were investigated using seven polymorphic restriction enzyme sites in the β-globin gene cluster. The haplotypes of 1392 chromosomes from ten ethnic populations living in southwest China were determined. Linkage equilibrium and recombination hotspot were found between the 5′ sites and 3′ sites of the β-globin gene cluster. 5′ haplotypes 2 (+−−−), 6 (−++−+), 9 (−++++) and 3′ haplotype FW3 (−+) were the predominant haplotypes. Notably, haplotype 9 frequency was significantly high in the southwest populations, indicating their difference with other Chinese. The interpopulation differentiation of southwest Chinese minority populations is less than those in populations of northern China and other continents. Phylogenetic analysis shows that populations sharing same ethnic origin or language clustered to each other, indicating current β-globin cluster diversity in the Chinese populations reflects their ethnic origin and linguistic affiliations to a great extent. This study characterizes β-globin gene cluster haplotypes in southwest Chinese minorities for the first time, and reveals the genetic variability and affinity of these populations using β-globin cluster haplotype frequencies. The results suggest that ethnic origin plays an important role in shaping variations of the β-globin gene cluster in the southwestern ethnic populations of China.

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Distribution of OCA2∗481Thr and OCA2∗615Arg, associated with hypopigmentation, in several additional populations

et al. 2011

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Characteristic [Beta]-Globin Gene Cluster Haplotypes of Evenkis and Oroqens in North China

Cited by 7 publications

References 28 publications

Characteristics of the β-Globin Gene Cluster Haplotypes of Three Han Chinese Populations at Beijing, Xi’an, and Kunming as Compared with Those of Other Asian Populations

Characteristics of the β-Globin Gene Cluster Haplotypes of Three Han Chinese Populations at Beijing, Xi’an, and Kunming as Compared with Those of Other Asian Populations

β-globin gene cluster haplotypes in ethnic minority populations of southwest China

Distribution of OCA2∗481Thr and OCA2∗615Arg, associated with hypopigmentation, in several additional populations

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