Characterising vancomycin's immunotoxic profile using Swiss and CFW mice as an experimental model

While antibiotics are clearly important treatments for infection, antibiotic-induced modulation of the immune system can have detrimental effects on pathogen clearance and immune functionality, increasing the risk of secondary infection. These injurious consequences may be mediated, at least in part, through effects on the mitochondria, the functioning of which is already compromised by the underlying septic process. Here, we review the complex interactions between antibiotic administration, immune cell and mitochondrial dysfunction.

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Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review

Miller

Singer

2022

Journal of Antimicrobial Chemotherapy

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Current World Literature

Gordon

2010

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Patch tests can detect a wide range of sensitivities to inorganic and organic chemicals, drugs, biologic molecules, inhalants acting as contactants, food allergens, allergens that have not been commercially extracted, and solid allergens. Because patch tests detect the full range of immunologic reactions, Gell and Coombs type I to IV, they may be uniquely reactive when other allergy tests are negative. Because of the large number of published studies that utilize patch testing, clinicians often can use a literature search of prior studies of similar problems, or for particular allergens, to choose technical details that make successful patch testing more likely.

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Characterising vancomycin's immunotoxic profile using Swiss and CFW mice as an experimental model

Cited by 2 publications

References 25 publications

Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review

Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review

Current World Literature

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