Abstract:16Manuka honey has broad-spectrum antimicrobial activity and unlike traditional antibiotics, 17 resistance to its killing effects has not been reported. However, its mechanism of action 18 remains unclear. Here we investigated the mechanism of action of manuka honey and its key 19 antibacterial components using a transcriptomic approach in a model organism, Pseudomonas 20 aeruginosa. We show that no single component of honey can account for its total 21 antimicrobial action, and that honey affects the expressi… Show more
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