2011
DOI: 10.1111/j.1742-1241.2011.02799.x
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Characterising the castration-resistant prostate cancer population: a systematic review

Abstract: Summary Background:  Castration‐resistant prostate cancer (CRPC) is an advanced form of prostate cancer associated with poor survival rates. However, characterisation of the disease epidemiology is hampered by use of varying terminology, definition and disease management. The aim of this review was to conduct a systematic review to provide greater clarity on the sum of the available epidemiologic evidence and to guide future research into the disease prevalence, progression, characteristics and outcome. Method… Show more

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Cited by 677 publications
(549 citation statements)
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“…36 The process by which PCa cells become hormone-resistant is unidentified, but it has been proposed that hormone depletion could result in a selective advantage to androgen-independent cells, which grow, repopulate the tumor and eventually migrate away from the original site to give rise to metastasis. 37 The evolution from hormone-dependent to hormone-independent PCa is supposed to be an effect of genetic alterations, 38 however numerous evidences are accumulating about the role of tumor microenvironment on the outset of a metastatic disease.…”
Section: Discussionmentioning
confidence: 99%
“…36 The process by which PCa cells become hormone-resistant is unidentified, but it has been proposed that hormone depletion could result in a selective advantage to androgen-independent cells, which grow, repopulate the tumor and eventually migrate away from the original site to give rise to metastasis. 37 The evolution from hormone-dependent to hormone-independent PCa is supposed to be an effect of genetic alterations, 38 however numerous evidences are accumulating about the role of tumor microenvironment on the outset of a metastatic disease.…”
Section: Discussionmentioning
confidence: 99%
“…Metastatic prostate cancer is characterized by a period during which the suppression of serum testosterone using androgen deprivation therapy is sufficient to control the disease (2). However, this period is followed by a transition to castration resistance, during which progression occurs despite the continued suppression of testosterone.…”
Section: Introductionmentioning
confidence: 99%
“…Conventional therapies for metastatic hormone-refractory PC are mostly palliative and fail to effectively improve the survival rate, at present [2]. Thus, further options are needed as alternatives or in addition to the classic therapeutic approaches to prevent or delay tumor growth, minimizing toxicity.…”
Section: Introductionmentioning
confidence: 99%