Characterising skeletal muscle haemoglobin saturation during exercise using near-infrared spectroscopy in chronic kidney disease

Wilkinson, Thomas J.; White, Alice E; Nixon, Daniel; Gould, Douglas W.; Watson, Emma; Smith, Alice C.

doi:10.1007/s10157-018-1612-0

Cited by 14 publications

(9 citation statements)

References 55 publications

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“…Our results indicate, as in the study of Wilkinson et al (2019), that as exercise intensity increases, a decrease in SmO 2 occurs, to a point at which an inflection appears. This is shown in the tablet graphics with a colour change (Humon, 2020).…”

Section: Discussionsupporting

confidence: 85%

“…Measuring SmO 2 can be a good way of controlling the intensity of exercise and adapting it to the needs of the person (Wilkinson et al, 2019). To accomplish this, it would be interesting to have studies that confirm the usefulness of SmO 2 , relating it to the data obtained with traditional techniques of performance assessment, assuming the peculiar responses of these subjects.…”

Section: Introductionmentioning

confidence: 99%

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Quadriceps Muscle Oxygenation during a Maximum Stress Test in Middle-Aged Athletes

Paredes-Ruiz¹,

Jodar-Reverte²,

Ferrer-López³

et al. 2020

Monten. J. Sports Sci. Med.

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Determining oxygen muscle saturation (SmO 2 ) using near-infrared spectroscopy (NIRS) is an emerging technique that is increasingly used in sports science; therefore, it is necessary to know its results in different population groups. We analysed it in a group of recreational participants in Nordic Walking. The purpose of this research was to analyse the SmO 2 values obtained at various times from testing in a group of athletes over 45. Thirty athletes (18 males) with a mean age of 51.3 years completed a maximal exercise testing in treadmill according to a modified Bruce protocol on a ramp. The electrocardiogram was continuously monitored. We measured VO 2 max (Metalyzer 3B). In addition, we placed a Humon Hex device on the right thigh to measure quadriceps oxygenation. Heart rate, VO 2 , and SmO 2 ratios were obtained based on the exercise intensity. We obtained a SmO 2 at startup of 63.3%, standard deviation (SD) 9.2%; SmO 2 declined 61.8%, SD 11.4%; SmO 2 in VO 2 max 57.4% SD 10.2% and SmO 2 5 minutes after starting recovery 72.5% SD7.9%. There was a relationship between ventilatory thresholds and variations in SmO 2 . There were no significant differences between the sexes. We could conclude that the minimum values of SmO 2 were related to the VO 2 max. During the recovery phase, the values were higher than at rest. The information obtained could be used to control and plan the training. KEY WORDS nordic walking, muscle oxygenation, maximal exercise testing ORIGINAL SCIENTIFIC PAPER

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Quadriceps Muscle Oxygenation during a Maximum Stress Test in Middle-Aged Athletes

Paredes-Ruiz¹,

Jodar-Reverte²,

Ferrer-López³

et al. 2020

Monten. J. Sports Sci. Med.

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“…As shown in Table 3, only one small study (24 cases and 6 controls) up to date has evaluated muscle oxygenation via NIRS in nondialysis CKD patients. In this study, Wilkinson et al [88] described NIRS-derived skeletal muscle O 2 saturation changes during and following exercise and found that CKD patients have dysfunctional kinetics that may indicate reduced mitochondria capacity to perform oxidative phosphorylation. Moreover, there are few studies examining muscle oxygenation via NIRS in ESKD individuals.…”

Section: Assessment Of Endothelial Dysfunction In Ckd: Functional Metmentioning

confidence: 87%

Assessment of Endothelial and Microvascular Function in CKD: Older and Newer Techniques, Associated Risk Factors, and Relations with Outcomes

Theodorakopoulou

Schoina

Sarafidis³

2020

Am J Nephrol

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Background: Endothelium is the inner cellular lining of the vessels that modulates multiple biological processes including vasomotor tone, permeability, inflammatory responses, hemostasis, and angiogenesis. Endothelial dysfunction, the basis of atherosclerosis, is characterized by an imbalance between endothelium-derived relaxing factors and endothelium-derived contracting factors. Summary: Starting from the semi-invasive venous occlusion plethysmography, several functional techniques have been developed to evaluate microvascular function and subsequently used in patients with CKD. Flow-mediated dilatation of the forearm is considered to be the “gold standard,” while in the last years, novel, noninvasive methods such as laser speckle contrast imaging and near-infrared spectroscopy are scarcely used. Moreover, several circulating biomarkers of endothelial function have been used in studies in CKD patients. This review summarizes available functional methods and biochemical markers for the assessment of endothelial and microvascular function in CKD and discusses existing evidence on their associations with comorbid conditions and outcomes in this population. Key Messages: Accumulated evidence suggests that endothelial dysfunction occurs early in CKD and is associated with target organ damage, progression of renal injury, cardiovascular events, and mortality. Novel methods evaluating microvascular function can offer a detailed, real-time assessment of underlying phenomena and should be increasingly used to shed more light on the role of endothelial dysfunction on cardiovascular and renal disease progression in CKD.

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“…Patients with mitochondrial dysfunction are unable to adequately use O2 for oxidative phosphorylation; instead, lactic acid accumulates early in exercise, which leads to exaggerated circulatory and ventilatory responses [ 33 ]. Research by our group showed greater than normal deoxygenation of skeletal muscle hemoglobin in CKD patients during an incremental exercise test, which we hypothesized to indicate reduced mitochondrial and oxidative phosphorylation capacity [ 34 ]. We have also recently shown that at the cellular level, exercise training has no effect on mitochondrial mass or the mRNA expression of key proteins involved in mitochondrial biogenesis [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Response of the oxygen uptake efficiency slope to exercise training in patients with chronic kidney disease

Wilkinson

Watson

Vadaszy

et al. 2020

Kidney Res Clin Pract

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Background: Chronic kidney disease (CKD) patients have poor cardiorespiratory fitness. Although cardiopulmonary exercise testing (CPET) is a universal assessment of cardiorespiratory fitness, values taken at 'peak' effort are strongly influenced by motivation and the choice of test endpoint. The oxygen uptake efficiency slope (OUES) integrates cardiovascular, musculoskeletal, and respiratory function into a single index to provide a more pragmatic and safer alternative to maximal testing. No research has explored whether exercise can improve the OUES in CKD patients. Methods: Thirty-two patients with non-dialysis CKD were recruited into a 12-week exercise program consisting of mixed aerobic and resistance training three times a week. CPET was conducted at baseline, and then, following a 6-week control period, at pre-and post-exercise intervention. Direct measurements of oxygen consumption (VȮ 2) and ventilatory parameters were collected. The OUES was calculated as the relationship between VȮ 2 and the log 10 of minute ventilation (VĖ). Results: No changes were observed in any variable during the control period, although modest increases in VȮ 2peak were observed. No meaningful changes were observed as a result of exercise in any cardiorespiratory value obtained. The OUES calculated at 100%, 90%, 75%, and 50% of exercise duration did not change significantly after 12 weeks of exercise training. Conclusion: Our results show that 12 weeks of exercise training had no beneficial effects on the OUES, which supports the modest change observed in VȮ 2peak. The lack of change in the OUES and other parameters could indicate a dysfunctional cardiorespiratory response to exercise in patients with CKD, likely mediated by dysfunctional peripheral metabolic mechanisms.

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Characterising skeletal muscle haemoglobin saturation during exercise using near-infrared spectroscopy in chronic kidney disease

Cited by 14 publications

References 55 publications

Quadriceps Muscle Oxygenation during a Maximum Stress Test in Middle-Aged Athletes

Quadriceps Muscle Oxygenation during a Maximum Stress Test in Middle-Aged Athletes

Assessment of Endothelial and Microvascular Function in CKD: Older and Newer Techniques, Associated Risk Factors, and Relations with Outcomes

Response of the oxygen uptake efficiency slope to exercise training in patients with chronic kidney disease

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