Characterising arthralgia in the preclinical phase of rheumatoid arthritis using MRI

Abstract

Subclinical inflammation as measured by MRI is present in 44% of patients with CSA. A combination of symptoms/characteristics incompletely differentiated patients with and without MRI inflammation.

Differences in the symptomatic phase preceding ACPA-positive and ACPA-negative RA: a longitudinal study in arthralgia during progression to clinical arthritis

“…The Leiden clinically suspect arthralgia cohort is a population-based inception cohort that started in April 2012 at the outpatient clinic of the Leiden University Medical Center 12. Inclusion required the presence of recent onset (<1 year) arthralgia of small joints that was considered suspect to progress to RA according to the clinical expertise of the rheumatologist.…”

“…Patients were followed until progression to clinical arthritis with a maximum of 2 years. The cohort has been described elsewhere in detail 12. At the time of analysis (1 November 2016), 441 patients were included, of whom 74 had developed clinical arthritis.…”

The diagnostic accuracy of the squeeze test to identify arthritis: a cross-sectional cohort study

“…Included were patients referred with arthralgia of recent-onset (symptom duration <2 years) and either arthritis confirmed at physical examination (arthritis was allowed to be present in any joint and not confined to hand or foot joints) or a clinical suspicion to progress to arthritis over time according to their rheumatologists 15. Patients with arthralgia that at first visit had diagnoses that were clearly other than suspected arthritis or apparent arthritis were not studied as there was no medical need to perform the squeeze test.…”

Problems of Rheumatoid Arthritis Immunopathology: Evolution of the Disease

“…Для стратификации пациентов в зависимости от риска развития РА был разработан «предсказательный алго-ритм» (prediction rule) [42,[198][199][200]. В недавних исследо-ваниях было показано, что артралгии (как единственный симптом) выявляются лишь у небольшого числа пациен-тов (7%), обращающихся к ревматологу поликлиники, но у 20% в процессе проспективного наблюдения разви-вается РА [201]. Установлено, что пациенты с «клиниче-ски подозрительной артралгией» (clinically suspect arthralgia), у которых имеются боли в суставах, в отсутствие вос-паления имеют высокий риск прогрессирования заболе-вания в РА.…”