Characterisation of the ecotoxicity of hospital effluents: A review

Orias, Frédéric; Perrodin, Yves

doi:10.1016/j.scitotenv.2013.02.064

Cited by 192 publications

(83 citation statements)

References 87 publications

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“…Consequently, our study and all the other ecotoxicological studies dealing with CSO contain 335 a bias attributable to the fact that the potentially considerable hazard represented by these types of 336 molecules is not taken into account. Indeed, as shown by Orias et al 36 purchased in the past and that they continue to use. Moreover, some of them linger on in the environment 345 for long periods (due to their high half-life times) and their release can continue due to rainfall events.…”

Section: The Case Of Pharmaceutical Compounds In Cso Studies 330mentioning

confidence: 94%

Identification and assessment of ecotoxicological hazards attributable to pollutants in urban wet weather discharges

Gosset

Durrieu

Orias

et al. 2017

Environ. Sci.: Processes Impacts

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Section: The Case Of Pharmaceutical Compounds In Cso Studies 330mentioning

confidence: 94%

Identification and assessment of ecotoxicological hazards attributable to pollutants in urban wet weather discharges

Gosset

Durrieu

Orias

et al. 2017

Environ. Sci.: Processes Impacts

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“…With the exception of oxazepam, the concentrations of these molecules in the psychiatric hospital effluent were lower than the maximal concentrations described in Orias and Perrodin (2013) for several hospital wastewaters. The concentration of oxazepam was higher in the French psychiatric wastewater effluent than in those detected in other psychiatric hospital effluents (Yuan et al (2013) or in hospital wastewaters (Orias and Perrodin 2013).…”

Section: Discussionmentioning

confidence: 55%

Proteomic changes in Corbicula fluminea exposed to wastewater from a psychiatric hospital

Bebianno

Sroda

Gomes

et al. 2015

Environ Sci Pollut Res

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The increase use of pharmaceutical compounds in veterinary practice and human population results in the ubiquitous presence of these compounds in aquatic ecosystems. Because pharmaceuticals are highly bioactive, there is concern about their toxicological effects in aquatic organisms. Therefore, the aim of this study was to assess the effects of an effluent from a psychiatric hospital (containing a complex mixture of 25 pharmaceutical compounds from eleven therapeutic classes) on the freshwater clam Corbicula fluminea using a proteomic approach. The exposure of C. fluminea to this complex effluent containing anxiolytics, analgesics, lipid regulators, beta blockers, antidepressants, antiepileptics, antihistamines, antihypertensives, antiplatelets and antiarrhythmics induced protein changes after 1 day of exposure in clam gills and digestive gland more evident in the digestive gland. These changes included increase in the abundance of proteins associated with structural (actin and tubulin), cellular functions (calreticulin, proliferating cell nuclear antigen (PCNA), T complex protein 1 (TCP1)) and metabolism (aldehyde dehydrogenase (ALDH), alcohol dehydrogenase, 6 phosphogluconate dehydrogenase). Results from this study indicate that calreticulin, PCNA, ALDH and alcohol dehydrogenase in the digestive gland and T complex protein 1 (TCP1)) and 6 phosphogluconate dehydrogenase in the gills represent useful biomarkers for the ecotoxicological characterization of psychiatric hospital effluents in this species.

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“…Some sources of toxicity values such as MSDSs/SDSs, Wikipharma, and literature reviews [59] present both lab test and predicted data. In some instances lab testing results are dissimilar and appear contradictory.…”

Section: Pbt Environmental Risk Ratio and Ecotoxicity Analysismentioning

confidence: 99%

“…Direct relationships between the low levels of pharmaceuticals identified in drinking water and adverse impacts to human health are not being observed at this time [46,47]. However, numerous laboratory studies [48][49][50][51][52][53][54][55][56] and literature reviews [57][58][59] have demonstrated the negative impacts of drugs to aquatic organisms.…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Dispensing and Wasting In Health Care Facilities, Amounts, Costs and Evaluation of Potential Ecologic Effects

Mankes¹,

Silver²

2017

SOJPPS

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Drug waste from hospitals contributes to environmental contamination. Patient excreta, bathing or discarding of excess drugs are some sources of drug waste. We report on the wasting of 84 drugs of 14 therapeutic classes in two hospitals in Albany, NY. We consider drug metabolism, excretion, disposal and ecotoxicity in strategies for reducing drug waste, costs and potential environmental damage.Medication (12,345) and waste collection (199) records for: drugs dispensed, returned and wasted were examined. Of 2,700 drugs available, 84 drugs from 14 classes, weighing 56 kg were dispensed to patients, and 2.3 kg were wasted. Twelve drugs accounted for 80 percent of the drug waste and cost $111,000. Of the top wasted and dispensed drugs, all but ibuprofen are persistant and none were bioaccumulative. Ibuprofen, ipratropium ondansetron and oxymetazoline are "very highly toxic" or "highly toxic". Environmental Risk Ratio (PEC/PNEC) for the 20 top drugs were"Insignificant" or "Cannot Be Excluded".Acetazolamide is the most toxic to fish. Dexamethasone has the greatest chronic toxicity to Ceriodaphnia. Ibuprofen is predicted to be very highly toxic (acute and chronic) to zebra mussel, crab and fish. Neostigmine is the most acutely toxic (LC50<1 mg/L) to Daphnia. Ondansetron is the most acutely toxic to green algae. All but 2 of the drugs were 5 to 100% excreted. Fourteen were metabolised. Active metabolites were formed from 2 drugs. Nicardipine, ondansetron and prednisone formed drug conjugates which were excreted. Incineration was the manufacturer's recommended disposal method.We recommend excess drugs be returned to the hospital pharmacy for disposal by incineration. Drug use and disposal should be monitored by an expert committee according to recognized guidelines of pharmaceutical management. Knowledge of the adverse impacts from the release of highly toxic drugs into the environment must influence drug selection and disposal.Key words: Waste; Ecotoxicity; Wastewater; Abbreviations AMCH = Academic Medical Center Hospital; ASTER = Assessment Tools for the Evaluation of Risk. United States Environmental Protection Agency https://archive.epa.gov/med/med_archive_03/web/html/ aster.html Last accessed 6/4/17; B = Bioaccumulation is the general term describing a process by which chemicals are taken up by an organism either directly from exposure to a contaminated medium or by consumption of food containing the chemical; EC50 = Effective Concentration producing an adverse effect in 50% of a test species; EbC50 or ErC50 = EC50 in terms of reduction of growth rate; EyC50 = EC50 in terms of change in biomass yield; Ecosar = Ecologic Structure Activity Relationships is a computerized predictive system that estimates aquatic toxicity. The program estimates a chemical's acute (short-term) toxicity and chronic (long-term or delayed) toxicity to aquatic organisms such as fish, invertebrates, and plants by using computerized Structure Activity Relationships (SARs). https://www.epa.gov/tsca-screening-tools/ ecological-structure-...

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Characterisation of the ecotoxicity of hospital effluents: A review

Cited by 192 publications

References 87 publications

Identification and assessment of ecotoxicological hazards attributable to pollutants in urban wet weather discharges

Identification and assessment of ecotoxicological hazards attributable to pollutants in urban wet weather discharges

Proteomic changes in Corbicula fluminea exposed to wastewater from a psychiatric hospital

Pharmaceutical Dispensing and Wasting In Health Care Facilities, Amounts, Costs and Evaluation of Potential Ecologic Effects

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