Characterisation of the cellular infiltrate in the foreign body granuloma of textile meshes with its impact on collagen deposition

Klinge, U.; Dietz, Ulrich; Fet, Ngwi; Klosterhalfen, B.

doi:10.1007/s10029-014-1220-1

Cited by 26 publications

(15 citation statements)

References 21 publications

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“…By investigating the FBR following PP mesh implantation in mice, we could show a high and continuous response of macrophages especially following mesh implantation over a period of up to 90 days. Our study extends the conventional histological descriptions of FBR (27), indicating a strong, chronic innate immune response with mononuclear cell infiltrates at all time points, the lack of a switch to an antiinflammatory response, and little formation of FB-associated giant cells, as revealed by extensive flow cytometric and histological immunophenotyping in mice and humans.…”

Section: Discussionsupporting

confidence: 78%

Polypropylene mesh implantation for hernia repair causes myeloid cell–driven persistent inflammation

Heymann¹,

Trotha²,

Preisinger³

et al. 2019

JCI Insight

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Section: Discussionsupporting

confidence: 78%

Polypropylene mesh implantation for hernia repair causes myeloid cell–driven persistent inflammation

Heymann¹,

Trotha²,

Preisinger³

et al. 2019

JCI Insight

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“…These phenotypes are governed primarily by the local tissue microenvironment (Davies & Taylor, 2015). To characterize the inflammatory infiltrate in more detail, in 2014 we had studied the expression of various markers in the FBG of meshes by immunohistochemistry (Klinge, Dietz, Fet, & Klosterhalfen, 2014). The abundant expression of CD68, CD45, as well as CD8 within the FBG, suggested the possibility that macrophages alone may not be playing the decisive part.…”

Section: Introductionmentioning

confidence: 99%

CD68+ macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining

et al. 2020

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Implants like meshes for the reinforcement of tissues implement the formation of a persistent inflammation with an ambient fibrotic reaction. In the inflammatory infiltrate several distinct cell types have been identified, but CD68+ macrophages are supposed to be most important. To investigate the collaboration among the various cell types within the infiltrate we performed at explanted meshes from humans double fluorescence staining with CD68 as a constant marker and a variety of other antibodies as the second marker. The list of second markers includes lymphocytes (CD3, CD4, CD8, CD16, CD56, FoxP3, and CD11b) stem cells (CD34), leucocytes (CD45, CD15), macrophages (CD86, CD105, CD163, and CD206); deposition of EC matrix (collagen-I, collagen-III, MMP2, and MMP8); Ki67 as a marker for proliferation; and the tyrosine-protein kinase receptor AXL. The present study demonstrates within the inflammatory infiltrate the abundant capability of CD68+ cells to co-express a huge variety of other markers, including those of lymphocytes, varying between 5 and 83% of investigated cells. The observation of co-staining was not restricted to a specific polymer but was seen with polypropylene fibers as well as with fibers made of polyvinylidene fluoride, although with differences in co-expression rates. The persisting variability of these cells without the functional reduction toward differentiated mature cell types may favor the lack of healing at the interface of meshes.

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“…Heterologous materials used in the surgical treatment of incisional hernias should have a very good integration capacity. [15][16][17] After introducing the mesh into the abdominal wall, a local inflammatory reaction occurs, followed by the migration of fibroblasts on the surface of the mesh, followed by the formation of collagen fibers, which allows the mesh to be integrated into the abdominal wall and to increase its resistance at this level [18,19].…”

Section: (Fig 3)mentioning

confidence: 99%

Comparative Study on the Efficiency of 2 Different Types of Meshes (Polypropylene and ProGripTM ) in the Surgical Treatment of Incisional Hernias

Suciu¹,

Hălmaciu²,

Fodor³

et al. 2018

Mat.Plast.

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Postoperative eventration is a quite common condition in patients with clinical records of abdominal surgery. The purpose of this study was to investigate the efficacy of use of 2 different types of meshes (Polypropylene mesh and ProGripTM mesh-self-gripping mesh) in the surgical treatment of incisional hernias. In this respect, we conducted a study in which we introduced 128 patients operated for incisional hernias. Patients were divided into 2 lots: group A (102 patients with polypropylene mesh) and group B (26 patients with ProGripTM mesh). From the analysis of the data studied, we noticed that the average duration of surgery and hospitalization for patients with ProGripTM mesh is lower compared to patients with polypropylene mesh. Also, the rate of local postoperative complications was lower when using the ProGripTM mesh (15.38%) than in the case of polypropylene mesh. In conclusion, we can state that the use of the ProGripTM heterologous mesh is beneficial in the surgical treatment of patients with incisional hernias. The major advantage of using this type of mesh is given by a shorter hospitalization period for these patients, as well as by a lower rate of local postoperative complications in these patients.

show abstract

Characterisation of the cellular infiltrate in the foreign body granuloma of textile meshes with its impact on collagen deposition

Cited by 26 publications

References 21 publications

Polypropylene mesh implantation for hernia repair causes myeloid cell–driven persistent inflammation

Polypropylene mesh implantation for hernia repair causes myeloid cell–driven persistent inflammation

CD68+ macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining

Comparative Study on the Efficiency of 2 Different Types of Meshes (Polypropylene and ProGripTM ) in the Surgical Treatment of Incisional Hernias

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