Characterisation of the Antibody Response in Sinopharm (BBIBP-CorV) Recipients and COVID-19 Convalescent Sera from the Republic of Moldova

Ulinici, Mariana; Suljič, Alen; Poggianella, Monica; Bonotto, Rafaela Milan; Rus, Katarina Resman; Paraschiv, Angela; Bonetti, Amedeo Marco; Todiras, Mihail; Corlăteanu, Alexandru; Groppa, Stanislav; Ceban, Emil; Petrovec, Miroslav; Marcello, Alessandro

doi:10.3390/vaccines11030637

Cited by 1 publication

(1 citation statement)

References 49 publications

(55 reference statements)

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“…demonstrating significant efficacy and safety without any major side effects. [166][167][168] Minor side effects (eg, local reaction at the injection site, headache, muscle pain) and clinically important adverse effects (eg, myocarditis, pericarditis, and thrombotic events) were reported following the COVID-19 vaccine. In addition, acute coronary syndromes, hypertension, and arrhythmias also have been reported as very rare cardiovascular side effects, without finally confirmed association.…”

Section: Covid-19 Vaccinesmentioning

confidence: 99%

Distinct Features of Vascular Diseases in COVID-19

Ceasovschih,

Sorodoc,

Shor

et al. 2023

JIR

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The Coronavirus Disease 2019 (COVID-19) pandemic was declared in early 2020 after several unexplained pneumonia cases were first reported in Wuhan, China, and subsequently in other parts of the world. Commonly, the disease comprises several clinical features, including high temperature, dry cough, shortness of breath, and hypoxia, associated with findings of interstitial pneumonia on chest X-ray and computer tomography. Nevertheless, severe forms of acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) are not limited to the respiratory tract but also may be extended to other systems, including the cardiovascular system. The bi-directional relationship between atherosclerosis and COVID-19 is accompanied by poor prognosis. The immune response hyperactivation due to SARS-CoV-2 infection causes an increased secretion of cytokines, endothelial dysfunction, and arterial stiffness, which promotes the development of atherosclerosis. Also, due to the COVID-19 pandemic, access to healthcare amenities was reduced, resulting in increased morbidity and mortality in patients at risk. Furthermore, as lockdown measures were largely adopted worldwide, the sedentary lifestyle and the increased consumption of processed nutrients or unhealthy food increased, and in the consequence, we might observe even 70% of overweight and obese population. Altogether, with the relatively low ratio of vaccinated people in many countries, and important health debt appeared, which is now and will be for next decade a large healthcare challenge. However, the experience gained in the COVID-19 pandemic and the new methods of patients’ approaching have helped the medical system to overcome this crisis and will hopefully help in the case of new possible epidemics.

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Section: Covid-19 Vaccinesmentioning

confidence: 99%