Characterisation of successive Acinetobacter baumannii isolates from a deceased haemophagocytic lymphohistiocytosis patient

Choi, Hyeon Jin; Kil, Min Cheol; Choi, Ji-Young; Kim, Sun-Ju; Park, Ki-Sup; Kim, Yae-Jean; Ko, Kwan Soo

doi:10.1016/j.ijantimicag.2016.09.024

Cited by 16 publications

(19 citation statements)

References 18 publications

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“…Point mutations in pmrA and pmrB upregulate their gene expression, resulting in remodeling of outer membrane ( Figure 1-IV ). 94 Recently, a plasmid-mediated colistin resistance gene, mcr-1 , has been reported in Escherichia coli . 95 , 96 Although mcr-1 gene has not been identified in A. baumannii , still it is speculated that progression from MDR Acinetobacter to pan drug resistance is unavoidable due to the arrival of transmissible colistin resistance mechanisms.…”

Section: Carbapenemsmentioning

confidence: 99%

Insight into <em>Acinetobacter baumannii</em>: pathogenesis, global resistance, mechanisms of resistance, treatment options, and alternative modalities

Asif

Alvi

Rehman

2018

IDR

238

224

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Acinetobacter baumannii, once considered a low-category pathogen, has emerged as an obstinate infectious agent. The scientific community is paying more attention to this pathogen due to its stubbornness to last resort antimicrobials, including carbapenems, colistin, and tigecycline, its high prevalence of infections in the hospital setting, and significantly increased rate of community-acquired infections by this organism over the past decade. It has given the fear of pre-antibiotic era to the world. To further enhance our understanding about this pathogen, in this review, we discuss its taxonomy, pathogenesis, current treatment options, global resistance rates, mechanisms of its resistance against various groups of antimicrobials, and future therapeutics.

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Section: Carbapenemsmentioning

confidence: 99%

Insight into <em>Acinetobacter baumannii</em>: pathogenesis, global resistance, mechanisms of resistance, treatment options, and alternative modalities

Asif

Alvi

Rehman

2018

IDR

238

224

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“…Adams et al [40] Park et al [41] Lesho et al [42] Beceiro et al [44] Rolain et al [46] Kim et al [48] Arroyo et al [34] Snitkin et al [47] Choi et al [43] Choi et al [45] Colistin resistance and dependence in A. baumannii sule polysaccharide (CPS) and efflux pumps [54,55]. For CPS production, reduced production of CPS in colistin-resistant mutants was observed in Klebsiella pneumoniae, which is a contradictory finding [56].…”

Section: P233s A)mentioning

confidence: 99%

“…baumannii seems to occur readily by simple mutation in both laboratories and patients [45,66], a genotyping study revealed that colistin-resistant A. baumannii isolates did not disseminate clonally [67].…”

Section: P233s A)mentioning

confidence: 99%

Old drug, new findings: colistin resistance and dependence of Acinetobacter baumannii

Choi

Lee

2017

Precis Future Med

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Colistin is an old drug, and its use has recently resurged because of increasing antibiotic resistance in gram-negative bacteria such as Acinetobacter baumannii. Although the colistin resistance rates in gram-negative bacteria are currently not high, many colistin-resistant isolates are being identified and the possibility of horizontal transmission of colistin resistance has increased because of the plasmid-borne colistin resistance gene mcr-1 (mobilized colistin resistance). In this review, we have discussed colistin resistance in A. baumannii. In addition, we have reviewed an abnormal phenomenon called colistin dependence in A. baumannii.

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“…Of the 38 isolates collected from various specimens in a single patient deceased from haemophagocytic lymphohistiocytosis ( Choi et al, 2017 ), 24 isolates (BL1–BL24) from the blood were included in this study. As shown in our previous study, the first blood isolate BL1 was collected on April 12, 2012, BL2–BL16 were isolated between May 17 and June 18, 2012, and BL17–BL24 were isolated from August 16–31, 2012.…”

Section: Methodsmentioning

confidence: 99%

“…We recently reported successively isolated MDR A. baumannii from a single patient who died from haemophagocytic lymphohistiocytosis ( Choi et al, 2017 ). In that study, A. baumannii isolates from blood were divided into two groups based on pulsed-field gel electrophoresis, suggesting that the strains isolated in the latter period did not recur, but that patients may be re-infected with a different strain isolated in the former period.…”

Section: Introductionmentioning

confidence: 99%

Genomic Analysis of Consecutive Acinetobacter baumannii Strains From a Single Patient

Kim

2018

Front. Microbiol.

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Acinetobacter baumannii is one of the most important nosocomial pathogens, and thus it is required to investigate how it disseminate in hospitals and infect patients. We performed whole genome sequencing for 24 A. baumannii strains isolated successively from the blood of a single patient to evaluate whether repeated infections were due to re-infection or relapse infection and to investigate within-host evolution. The whole genome of the first strain, BL1, was sequenced de novo using the PacBio RSII system. BL2–BL24, were sequenced with an Illumina Hiseq4000 and mapped to the genome sequences of BL1. We identified 42 single-nucleotide variations among the strains. The SNVs differentiated the strains into three groups, BL1, BL2–BL16, and BL17–BL24, indicating that the patient suffered from re-infections or co-infections by similar, but different strains. The results also showed that A. baumannii strains in each group were rather stable at the genomic level. Our study emphasizes the importance of intensive infection control.

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Characterisation of successive Acinetobacter baumannii isolates from a deceased haemophagocytic lymphohistiocytosis patient

Cited by 16 publications

References 18 publications

Insight into <em>Acinetobacter baumannii</em>: pathogenesis, global resistance, mechanisms of resistance, treatment options, and alternative modalities

Insight into <em>Acinetobacter baumannii</em>: pathogenesis, global resistance, mechanisms of resistance, treatment options, and alternative modalities

Old drug, new findings: colistin resistance and dependence of Acinetobacter baumannii

Genomic Analysis of Consecutive Acinetobacter baumannii Strains From a Single Patient

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