Characterisation of Single Nucleotide Polymorphisms and Haplotypes of MSTN Associated with Growth Traits in European Sea Bass (Dicentrarchus labrax)

Functional Characterization of the Almstn2 Gene and Its Association with Growth Traits in the Yellowfin Seabream Acanthopagrus latus (Hottuyn, 1782)

“…In the present study, we used sequencing to detect three SNPs (SNP1885, SNP1888, and SNP1915) in the mstn intron in the A. latus population. All three loci of SNP-Almstn2b +1885 A/G, SNP-Almstn2b +1888 A/G, and SNP-Almstn2b +1915 A/G had a significant association with the morphological characteristics, especially weight traits, which were similar to the above study [26,33].…”

“…Moreover, as a key breeding candidate gene in L. crocea, mstn was implicated in the regulation of morphology determination [42]. Furthermore, in the analysis of SNP loci and morphology trait association, the total weight, fillet weight, and standard length was significantly related to the mstn SNP5252T > A locus in intron 2 in D. labrax [33]. The relationship between the abdominal length, pre-anal length, post-anal length, standard height, head length, head width, and body length and SNP14873C > T locus in exon 3 of D. labrax mstn was prominent (p < 0.05) [33].…”

“…Additionally, many mammal studies have shown the presence of SNPs in the mstn gene [35,36]. In teleosts, nine SNPs and two indels were identified in exons 1-3 of mstn in the D. labrax population [33]. One of the SNPs which was scanned in the 5 -flanking region of the mstn1b gene had a prominent association with harvest traits in S. salar [25].…”

“…Starting with the fishery industry, inhibiting the expression of mstn is helpful for the management of muscle development in teleost fish, as well as for developing new policies to control the quality and production of meat. So far, numerous mstn genes have been identified in teleost fish, such as the gilthead seabream S. aurata [14], tilapia Oreochromis mossambicus [15], channel catfish Ictalurus furcatus [16], cyprinid loach Misgurnus anguillicaudatus [17], common carp Cyprinus carpio [18], zebrafish Danio rerio [19], rainbow trout Oncorhynchus mykiss [20], Japanese flounder Paralichthys olivaceus [21,22], yellowcheek carp Elopichthys bambusa [23], Atlantic salmon Salmo salar [24,25], mandarin fish Siniperca chuatsi [26], large yellow croaker Larimichthys crocea [27], grass carp Ctenopharyngodon idellus [28], Tibet fish Gymnocypris przewalskii [29], African lungfsh Protopterus annectens [30], pufferfish Takifugu bimaculatus [31], Nile tilapia Oreochromis niloticus [32], European sea bass Dicentrarchus labrax [33], and A. latus [34]. The functional identification of this gene lays the foundation for the genetic breeding of teleosts.…”