Characterisation of phenolic antioxidants in <i>Scabiosa arenaria</i> flowers by LC–ESI-MS/MS and NMR

Hlila, Malek Besbes; Mosbah, Habib; Zanina, Nahla; Nejma, Aymen Ben; Jannet, Hichem Ben; Aouni, Mahjoub; Selmi, Boulbaba

doi:10.1111/jphp.12561

Cited by 8 publications

(5 citation statements)

References 37 publications

(75 reference statements)

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“…A debris ion at m / z 269 was examined in peak 9, and the [M − H] − was 431.0984, indicating a loss of glucoside. Therefore, peak 9 was considered to be apigenin-7-O-glucoside (apigetrin) [25]. For peak 13 (tR = 19.34 min), the molecular ion [M + H] + was seen at m / z 317.9656 in the positive mode.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau

et al. 2019

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Incarvillea compacta Maxim is a traditional Tibetan plant widely used to treat rheumatic pain and bruises. We conducted qualitative analyses by liquid chromatography-mass spectrometry and quantitative analyses of the total phenols, flavonoids, and alkaloids content of different extracts of I. compacta Maxim. Antioxidant and analgesic activity were analyzed. The results showed that the methanol extract had the highest content of the various ingredients. A total of 25 constituents were identified, of which compounds 1–23 were found for the first time in this plant. The water extract had the highest capacity to clear free radicals in the antioxidant test. The water extract had dose-dependent analgesic effects in the first and second phase in a formalin test. The latency of pain from a hot-plate test was augmented by the water extract when the dose was greater than or equal to 30 g/kg. The water extract significantly decreased the amount of writhing in a dose-dependent manner compared with the control group in the acetic acid-induced writhing test. These results showed that I. compacta Maxim is a new antioxidant and analgesic agent, and this study provides information on its ingredients for further study.

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Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau

et al. 2019

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“…The extract of S. flavida significantly attenuated the amount of OS in the fibroblast cells almost with a power like EA. The genus Scabiosa has been enriched by phenolic constituents, in particular flavonoids, iridoids, and triterpene saponins, allowing it to possess antioxidant, anti‐inflammatory, analgesic, and many other biological actions . The antioxidant and scavenging capacity of F .…”

Section: Discussionmentioning

confidence: 99%

Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells

Momtaz

Baeeri

Rahimifard

et al. 2018

J of Cellular Biochemistry

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Aging contributes to an increased risk of developing a number of neurodegenerative and chronic disorders, predominantly related to oxidative stress (OS) and defects in the antioxidant balance. This study focused on the antisenescence effect of four plant species (Falcaria vulgaris, Ixiolirion tataricum, Ajuga chamaecistus, and Scabiosa flavida) on H2O2‐induced premature senescence in rat NIH3T3 fibroblasts, which were found to be rich in effective phytochemicals with traditional ethnobotanical backgrounds. Plant materials were collected, identified, and extracted. To determine the viability of NIH3T3 cells, an MTT assay was conducted. The levels of OS markers and the senescence‐associated ß‐galactosidase (SA‐ß‐GAL) activity were analyzed by the Elisa reader. The cell cycle pattern was evaluated by flow cytometry. The expression of senescence‐related inflammatory cytokines and the molecules involved in aging signaling pathways were investigated using the real‐time reverse transcription polymerase chain reaction (RT‐PCR). H2O2 treatment decreased cell viability and increased lipid peroxidation (LPO) and the reactive oxygen species (ROS) in NIH3T3s. However, S. flavida exhibited low cytotoxicity, reduced OS and SA‐ß‐GAL activities in NIH3T3 cells compared with the H2O2‐treated group. I. tataricum was the second best plant, although it was more toxic to NIHT3T cells. S. flavida decreased G0/G1 arrest and facilitated the G2/M transition of NIH3T3s, also downregulated the expression of p38, p53, p16, and the related inflammatory mediators. S. flavida potentially modulated senescence‐associated hallmarks in fibroblasts exposed to H2O2, thus it may inhibit the aging process via controlling the OS. Therefore it is a promising candidate for future antiaging explorations.

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“…[16,17] Many of Scabiosa species contain triterpenes, triterpene glycosides, triterpene saponins, iridoids, iridoid glucosides, monoterpenoid glucoindole alkaloids, coumarins and flavonoids. [18][19][20][21][22] It has been reported that extracts of S. tschilliensis and S. comosa, [23] S. arenaria, [24] S. tschilliensis, [25] compounds isolated from S. arenaria flowers [26] and S. comosa influorescence [27] have antioxidant property. Swerosid and seco-iridoid isolated from S. columbaria roots, [28] essential oil from fruit, stem and leaf and flowers of S. arenaria, [16] ethanol extracts of S. arenaria, [29] Lomelosia olivieri (Coult.)…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that extracts of S. tschilliensis and S. comosa , [23] S. arenaria , [24] S. tschilliensis , [25] compounds isolated from S. arenaria flowers [26] and S. comosa influorescence [27] have antioxidant property. Swerosid and seco‐iridoid isolated from S. columbaria roots, [28] essential oil from fruit, stem and leaf and flowers of S. arenaria , [16] ethanol extracts of S. arenaria , [29] Lomelosia olivieri (Coult.)…”

Section: Introductionmentioning

confidence: 99%

Investigation of Phytochemical, Antioxidant and Antidiabetic Potentials of Scabiosa L. (Caprifoliaceae) Species with Chemometric Methods

Albayrak,

Aksoy,

Yilmaz

et al. 2024

Chemistry & Biodiversity

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In this research, the total phenolic and flavonoid amounts, phenolic compositions, in vitro antioxidant, antibacterial and antidiabetic properties of the methanol extracts obtained from Scabiosa L. (Caprifoliaceae) species distributed in the flora of Türkiye were investigated using chemometric methods. For this purpose, principal component (PCA) and agglomerative hierarchical clustering analysis were performed as chemometric methods. Chlorogenic acid, quinic acid and cyranoside were determined in the extracts. According to chemometric analysis, S. columbaria subsp. ochroleuca var. ochroleuca and S. triniifolia species were found to be valuable in terms of methanol extract yields, total phenolic and flavonoid contents, antioxidant and antidiabetic activities while S. columbaria subsp. ochroleuca var. webbiana species were found to be valuable in terms of phenolic composition. The methanol extracts of Scabiosa species showed high antioxidant activity, with high phenolic and flavonoid contents. Among the tested 13 bacteria, Scabiosa extracts showed only low activity against Klebsiella pneumoniae, Streptococcus pneumoniae and Pseudomonas aeruginosa. The extracts showed high α‐amylase and α‐glucosidase inhibitory activity. The results show that Scabiosa methanol extracts may be a source of alternative antioxidants that may be beneficial in slowing or preventing the progression of various oxidative stress‐related diseases.

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Characterisation of phenolic antioxidants in Scabiosa arenaria flowers by LC–ESI-MS/MS and NMR

Abstract: The results of the present work indicate that S. arenaria flower's ethyl acetate extract could be used as natural antioxidant agents in food preservation and human health.

Cited by 8 publications

References 37 publications

Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau

Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau

Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells

Investigation of Phytochemical, Antioxidant and Antidiabetic Potentials of Scabiosa L. (Caprifoliaceae) Species with Chemometric Methods

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