Characterisation of Exiguobacterium aurantiacum isolates from blood cultures of six patients

Abstract

Exiguobacterium spp. are alkaliphilic, halotolerant, non-spore-forming Gram-positive bacilli, hitherto uncharacterized from human infections. Six isolates of Exiguobacterium aurantiacum were obtained from patients with bacteraemia, three of whom had myeloma. All isolates formed orange-yellow pigmented colonies on blood agar, were catalase- and DNase-positive, and grew on nutrient agar at pH 10 and in the presence of NaCl 6% w/v. The six isolates were susceptible to all antimicrobial agents tested and were uniform in their fatty acid and mass spectrum profiles.

A survey of the microbial populations in some Australian coalbed methane reservoirs

“…E. aurantiacum are non-spore forming alkaliphilic rods, capable of aerobic or anaerobic growth at 20-41°C (Fruhling et al, 2002;Rodrigues et al, 2006). They have been found in environments as diverse as lakes and human blood (Lopez et al, 2005;Pitt et al, 2007). A single amplicon related to a Geobacillus species was observed in a coal sample, CSR 6.…”

Exiguobacterium sp. A1b/GX59 isolated from a patient with community-acquired pneumonia and bacteremia: genomic characterization and literature review

“…As documented, most infections due to Exiguobacterium spp. had underlying diseases, such as liver cirrhosis [2], intravenous drug abuse and multiple myeloma [6]. However, the patient in present study was in a generally healthy condition, though he suffered from T2DM.…”

“…The clinical characterizations of Exiguobacterium species isolated previously from different infectious samples were listed in Table 3 [2–6]. As documented, most infections due to Exiguobacterium spp.…”

“…To better understand the characteristics of Exiguobacterium infections, PubMed was searched and 5 related reports were included for comparison [2–6]. …”

“…To date, only a few cases of bacteremia and skin infection were documented in English literature [2–6]. However, the clinical infection due to the micro-organism might be probably underdiagnosed or unreported, for it tended to be misidentified by routine commercial methods [2–6]. As an emerging pathogen, its pathogenesis should be clarified.…”