Characterisation of copper oxide nanoparticles for antimicrobial applications

Ren, Guogang; Hu, Dawei; Cheng, Eileen W.C.; Vargas-Reus, Miguel A.; Reip, Paul; Allaker, Robert P.

doi:10.1016/j.ijantimicag.2008.12.004

Cited by 1,330 publications

(686 citation statements)

References 11 publications

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“…In the form of nanoparticles, the antimicrobial properties of copper are among the most described (Ren et al, 2009). Compared to traditional antibiotics, nanoparticles are effective at concentrations 1000 times lower.…”

Section: Discussionmentioning

confidence: 99%

Copper Nanoparticles as Potential Antimicrobial Agent in Disinfecting Root Canals: A Systematic Review

Sánchez‐Sanhueza

Fuentes‐Rodríguez

Bello-Toledo

2016

Int. J. Odontostomat.

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ABSTRACT:Copper was registered as the first solid antimicrobial material. Its availability makes it an important option as an antibacterial agent. At nanoparticle size it does not exceed 100 nm, allowing close interaction with microbial membranes, enhancing its effect even more. Copper generates toxic hydroxyl radicals that damage cell membranes of Gram-negative and Gram-positive bacteria, among the latter, Enterococcus faecalis, which are present in infected radicular canals. Synthesis of metal nanoparticles with antimicrobial properties has become a viable alternative and has promising applications in the fight against pathogenic microorganisms. Furthermore, the use of some polymers to stabilize nanoparticles increases their release time and may as well decrease the risk of bacterial recolonization and biofilm formation within the ducts, enhancing the antimicrobial properties of these compounds.The aim of this article is to conduct a systematic review of the literature on antimicrobial copper nanoparticles, their current applications and their potential use in the area of oral health, specifically in the field of endodontics.

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Section: Discussionmentioning

confidence: 99%

Copper Nanoparticles as Potential Antimicrobial Agent in Disinfecting Root Canals: A Systematic Review

Sánchez‐Sanhueza

Fuentes‐Rodríguez

Bello-Toledo

2016

Int. J. Odontostomat.

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“…In nano-Cu, for instance, the total amount of f-Cu 2+ increased slightly within the first 24 h but in that same period f-Cu 2+ ), and NOM. 11 The predominant species is highly dependent on the concentrations of OH − and CO 3 2− (i.e., pH and water hardness). 11 As we showed in this study, organic ligands from biota in aquatic systems may play an important role in Cu-complexation, and thus, its bioavailability and toxicity to organisms.…”

Section: Speciationmentioning

confidence: 99%

Influence of Extracellular Polymeric Substances on the Long-Term Fate, Dissolution, and Speciation of Copper-Based Nanoparticles

Adeleye

Conway

Pérez

et al. 2014

Environ. Sci. Technol.

210

217

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ABSTRACT:The influence of phytoplankton-derived soluble extracellular polymeric substances (EPS), pH, and ionic strength (IS) on the dissolution, speciation, and stability of nano-CuO, nano-Cu, and Kocide (a micron sized Cu(OH) 2 -based fungicide) was investigated over 90 days. EPS improved the stability of commercial copper-based nanoparticles (CBNPs) in most conditions, in addition to influencing their dissolution. The dissolution rate was pH 4 ≫ pH 7 > pH 11. The presence of EPS correlated with higher dissolved Cu at pH 7 and 11, and lower dissolved Cu at pH 4. More dissolution was observed at higher IS (NaCl) due to complexation with Cl − . Dissolution of nano-CuO at pH 7 increased from 0.93% after 90 days (without EPS) to 2.01% (with 5 mg-C EPS/L) at 10 mM IS. Nano-CuO dissolved even more (2.42%) when IS was increased to 100 mM NaCl (with EPS). The ratio of freeCu 2+ /total dissolved Cu decreased in the presence of EPS, or as pH and/or IS increased. On a Cu mass basis, Kocide had the highest dissolved and suspended Cu at pH 7. However, dissolution of nano-Cu resulted in a higher fraction of free Cu 2+ , which may make nano-Cu more toxic to pelagic organisms. ■ INTRODUCTIONGlobal production of copper-based nanoparticles (CBNPs) was estimated at ∼200 t/yr in 2010, and is increasing. 1 CBNPs have found use in cosmetics, pigments, paints and coatings, electronics, and pesticides. 2−4 These applications may lead to direct exposure of CBNPs to the environment due to normal use, product wear-and-tear, and/or end-of-life disposal. 1 Toxicity of CBNPs and composites to organisms has been demonstrated. 2,5−8 It is therefore important to understand the long-term fate and transformations of these materials in aquatic systems in order to predict exposure to at-risk organisms.Stability and dissolution of engineered nanoparticles (ENPs) depend on ionic strength (IS), pH, and natural organic material (NOM). 9−12 Rapid aggregation of nano-Cu was reported in freshwater by Griffitt et al. 5 The authors also found that less than 0.1% of the nano-Cu dissolved in 48 h in the freshwater media used (pH 8.2). 98% dissolution of nano-Cu was however reported at pH 6 in "uterine-fluid" after a week, 13 demonstrating the importance of pH and media composition on CBNPs' dissolution. Mudunkotuwa and co-workers 14 reported increased dissolution of aged and new CBNPs in the presence of organic acids. Similarly, Worthington et al. 15 showed that the chitosan improved stability and dissolution of nano-Cu. To our knowledge, no studies have previously investigated the effects of naturally occurring NOM such as extracellular polymeric substances (EPS) on the stability and dissolution of CBNPs. EPS are synthesized by microorganisms, which are abundant in natural aquatic systems. EPS are mainly composed of polysaccharides, proteins, nucleic acids, and other polymers; and their composition may vary spatially and temporally even within the same species. 16 EPS may interact with ENPs, thus affecting their fate and transformation. 17 Additional...

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“…Inorganic NPs are used in several applications in infection control and wound management: i.e., antibiotic delivery systems to treat disease, antibacterial coatings for implantable devices and improved materials to prevent infection and promote wound healing, antibacterial vaccines to control bacterial infections, and bacterial detection systems for microbial diagnostics [47].…”

Section: Collagen-inorganic Nanoparticles Compositesmentioning

confidence: 99%

Collagen-Nanoparticles Composites for Wound Healing and Infection Control

Grigore

Grumezescu

Holban

et al. 2017

Metals

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Nowadays, the world is facing a serious crisis represented by the rapid emergence of resistant bacteria, which jeopardizes the efficacy of antibiotics. This crisis has been attributed to the overuse and misuse of antibiotics, as well as the cessation of new drug production by the pharmaceutical industry. Therefore, bacterial strains with resistance to multiple antibiotic classes have appeared, such as Staphylococcus aureus, Acinetobacter spp. and Pseudomonas aeruginosa. This review aims to provide an updated summary of the current approach to the treatment of infections due to resistant microorganisms, with a focus on the application of the antimicrobial effects of inorganic nanoparticles in combination with collagen to promote wound healing. In addition, the paper describes the current approaches in the field of functionalized collagen hydrogels capable of wound healing and inhibiting microbial biofilm production.

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Characterisation of copper oxide nanoparticles for antimicrobial applications

Cited by 1,330 publications

References 11 publications

Copper Nanoparticles as Potential Antimicrobial Agent in Disinfecting Root Canals: A Systematic Review

Copper Nanoparticles as Potential Antimicrobial Agent in Disinfecting Root Canals: A Systematic Review

Influence of Extracellular Polymeric Substances on the Long-Term Fate, Dissolution, and Speciation of Copper-Based Nanoparticles

Collagen-Nanoparticles Composites for Wound Healing and Infection Control

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