2017
DOI: 10.1590/0074-02760170121
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Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil

Abstract: The classification of human papillomavirus (HPV) intratypic lineages by complete genome sequencing is a determinant in understanding biological differences in association with this disease. In this work, we have characterised complete HPV genomes from southern Brazil. Fifteen cervicovaginal Pap smear negative samples previously categorised as HPV-positive were sequenced using ultradeep sequencing, and 18 complete genomes from 13 different HPV types were assembled. Phylogenetic and genetic distance analyses wer… Show more

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Cited by 9 publications
(7 citation statements)
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“…The genomes sequenced in the current study were compared to the 47 complete HPV18 genomes described previously [ 14 , 15 , 16 , 30 , 31 ] and currently available in NCBI Genbank. The present study adds 51 new unique sequences ( Figure 2 ).…”
Section: Resultsmentioning
confidence: 99%
“…The genomes sequenced in the current study were compared to the 47 complete HPV18 genomes described previously [ 14 , 15 , 16 , 30 , 31 ] and currently available in NCBI Genbank. The present study adds 51 new unique sequences ( Figure 2 ).…”
Section: Resultsmentioning
confidence: 99%
“…Regarding the number, it ranged from 3 to 34 with 14.20 ± 8.18 as a mean ±SD and 12.50 as a median value. Severity of STs varies from mild (1-10), moderate (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) and severe (>30), with (3, 7.5%), (23, 57.5%) (14, 35%) of the patients had severe, moderate and mild STs respectively.…”
Section: Resultsmentioning
confidence: 99%
“…En nuestro estudio no se encontró significancia estadística entre la infección por virus de papiloma humano y el número de partos vaginales, similar a lo hallado por Rajkumar y col. (33) . Tampoco se halló significancia estadística entre el haber tenido alguna lesión de cuello uterino y la infección por VPH, lo que difiere de estudios (31) , Oliveira (34) , Motoyama (35) , Naqvi, Wajid y Mitra (36) y Harden y Munger (13) . Los antecedentes de ITS, uso de anticonceptivo hormonal y/o condón y fumar no mostraron significancia estadística con el resultado positivo por VPH; esto difiere con los estudios de Hellberg y de Vaccarella, que encuentran relación entre estos factores y la infección por VPH (23,37,38) .…”
Section: Discussionunclassified