Characterisation of chicken ZAP

Goossens, Kate E.; Karpala, Adam J.; Ward, Alister C.; Bean, Andrew G. D.

doi:10.1016/j.dci.2014.05.011

Cited by 22 publications

(27 citation statements)

References 24 publications

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“…In mammalian species, there are two short and long isoforms of ZAP. However, the only long isoform of ZAP has been identified in chickens [86]. In mammalian species, the shorter isoform of ZAP is known as the regulator of RIG-I signaling.…”

Section: Rig-i Like Receptormentioning

confidence: 99%

Antiviral responses against chicken respiratory infections: Focus on avian influenza virus and infectious bronchitis virus

2020

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Section: Rig-i Like Receptormentioning

confidence: 99%

Antiviral responses against chicken respiratory infections: Focus on avian influenza virus and infectious bronchitis virus

2020

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“…To a limited extent IRGs have been investigated in more detail in birds [22–24]. In analogy to the mammalian system the avian Mx orthologue was considered to have potent antiviral properties [25, 26].…”

Section: Introductionmentioning

confidence: 99%

Tissue and time specific expression pattern of interferon regulated genes in the chicken

Röll

Härtle²,

Lütteke

et al. 2017

BMC Genomics

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BackgroundType I interferons are major players against viral infections and mediate their function by the induction of Interferon regulated genes (IRGs). Recently, it became obvious that these cytokines have a multitude of additional functions. Due to the unique features of the chickens’ immune system, available data from mouse models are not easily transferable; hence we performed an extensive analysis of chicken IRGs.ResultsA broad database search for homologues to described mammalian IRGs (common IRGs, cIRGs) was combined with a transcriptome analysis of spleen and lung at different time points after application of IFNα. To apply physiological amounts of IFN, half-life of IFN in the chicken was determined. Interestingly, the calculated 36 min are considerably shorter than the ones obtained for human and mouse. Microarray analysis revealed many additional IRGs (newly identified IRGs; nIRGs) and network analysis for selected IRGs showed a broad interaction of nIRGs among each other and with cIRGs. We found that IRGs exhibit a highly tissue and time specific expression pattern as expression quality and quantity differed strongly between spleen and lung and over time. While in the spleen for many affected genes changes in RNA abundance peaked already after 3 h, an increasing or plateau-like regulation after 3, 6 and 9 h was observed in the lung.ConclusionsThe induction or suppression of IRGs in chickens is both tissue and time specific and beside known antiviral mechanisms type I IFN induces many additional cellular functions. We confirmed many known IRGs and established a multitude of so far undescribed ones, thus providing a large database for future research on antiviral mechanisms and additional IFN functions in non-mammalian species.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-017-3641-6) contains supplementary material, which is available to authorized users.

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“…These genes exert antiviral effector functions, many of which are still not fully understood (15). In chickens, ISGs are not generally well described with the exception of the chicken ZAP and viperin genes (32, 33). …”

Section: Immunity Against Alvmentioning

confidence: 99%

“…Interestingly, chicken biliary exosomes were found to contain ZAP and these inhibited ALV-J replication in vitro (35). Chicken ZAP is expressed in response to H5N1 and IBDV infections (32), but whether chicken ZAP is the key factor that inhibited ALV-J replication requires further study. It is important to identify and verify additional chicken ISGs to broaden our understanding of innate immune responses to develop protective strategies against ALV infections in chickens.…”

Section: Immunity Against Alvmentioning

confidence: 99%

Immunity to Avian Leukosis Virus: Where Are We Now and What Should We Do?

Feng

Zhang

2016

Front. Immunol.

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Avian leukosis virus (ALV) is an avian oncogenic retrovirus causing enormous economic losses in the global poultry industry. Although ALV-related research has lasted for more than a century, there are no vaccines to protect chickens from ALV infection. The interaction between chickens and ALV remains not fully understood especially with regard to the host immunity. The current review provides an overview of our current knowledge of innate and adaptive immunity induced by ALV infection. More importantly, we have pointed out the unknown area involved in ALV-related studies, which is worthy of our serious exploring in future.

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Characterisation of chicken ZAP

Cited by 22 publications

References 24 publications

Antiviral responses against chicken respiratory infections: Focus on avian influenza virus and infectious bronchitis virus

Antiviral responses against chicken respiratory infections: Focus on avian influenza virus and infectious bronchitis virus

Tissue and time specific expression pattern of interferon regulated genes in the chicken

Immunity to Avian Leukosis Virus: Where Are We Now and What Should We Do?

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