Characterisation of antimicrobial resistance patterns and class 1 integrons among Escherichia coli and Salmonella enterica serovar Choleraesuis strains isolated from humans and swine in Taiwan

Hsu, Shu‐Chen; Chiu, Tsai-Hsin; Pang, Jen-Chieh; Hsuan-Yuan, Chao-Hsiu; Chang, Gan-Nan; Tsen, Hau‐Yang

doi:10.1016/j.ijantimicag.2005.11.020

Cited by 66 publications

(64 citation statements)

References 40 publications

(61 reference statements)

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“…The results in this study show that multidrug-resistance is common in Salmonella isolates from poultry and swine, which are similar to those previously reported in Thailand [4,20] and from other countries [7,9,13]. High proportions of resistant S. enterica from swine and poultry were in agreement with a recent study conducted in Thailand that reported the highest resistance rate in Salmonella spp.…”

Section: Discussionsupporting

confidence: 91%

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Susceptibilities to Antimicrobials and Disinfectants in Salmonella Isolates Obtained from Poultry and Swine in Thailand

et al. 2008

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ABSTRACT. Salmonella enterica isolates from poultry (n=125) and swine (n=132) in Thailand were investigated for antibiotic resistance, susceptibility to disinfectants (benzalkonium chloride (BKC), chlorhexidine digluconate (CHX), zinc chloride and copper sulfate) and cyclohexane tolerance. Forty-two percent were of multiple resistance to antibiotics. The minimum inhibitory concentrations (MICs) of all antibiotics against isolates from swine were higher than that against the isolates from poultry. There were generally few variations in MICs to all disinfectants, indicating that the isolates had either no or only a limited degree of developed resistance to the disinfectants tested. Only 5 isolates (1.9%) were tolerant to cyclohexane. The proton-dependent efflux systems did not play a major role in the reduced susceptibility to BKC and CHX, since susceptibility was not restored when an efflux inhibitor, carbonyl cyanide m-chlorophenylhydrazone (CCCP) was present. Successive exposure to subinhibitory concentrations of BKC and CHX generated mutants resistant to BKC and CHX. A spontaneous BKC-resistant derivative expressed cross-resistance to antibiotics, chloramphenicol and erythromycin. The mechanism responsible for cross-resistance between BKC and antibiotics was not driven by the proton motif force (PMF). KEY WORDS: benzalkonium chloride, multiple antibiotic resistance, Salmonella enterica, proton-dependent efflux system.

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Section: Discussionsupporting

confidence: 91%

“…CuSO 4 and ZnCl 2 were dissolved in distilled water, of which pH was adjusted to 5.5 for ZnCl 2 . Multidrug resistance (MDR) was defined as isolates being resistant to 2 or more separate classes of antibiotics [13].…”

Section: Methodsmentioning

confidence: 99%

Susceptibilities to Antimicrobials and Disinfectants in Salmonella Isolates Obtained from Poultry and Swine in Thailand

et al. 2008

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“…Because the study focused on Salmonella, the isolated E. coli bacteria were not investigated further. Resistance to nalidixic acid has been found in 61 to 68% of commensal E. coli strains in humans and in 58% of isolates from pigs (32,33). Thus, it can be assumed that in the pigs used in the present study, there were multiple commensal E. coli strains carrying this resistance.…”

Section: Fig 3 Cd4mentioning

confidence: 80%

No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104

Janczyk

Kreuzer

Aßmus

et al. 2013

Appl Environ Microbiol

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b Twenty-eight-day-old weaned pigs were fed diets with a low (LZn), medium (MZn), or high (MZn) Zn concentration (50 to 80, 150, or 2,500 mg Zn/kg of diet, respectively) provided as zinc oxide (ZnO)(24 pigs per group). They were infected orally with Salmonella enterica serovar Typhimurium DT104 on day 32. Salmonellae were cultivated from feces (up to 42 days postinfection [dpi]) and organs (2 and 42 dpi). Activation of the adaptive systemic and mucosal immune systems was investigated by recording anti-Salmonella IgG levels and levels of B and T lymphocyte subpopulations in blood and gut-associated lymphatic tissue. Growth performance was recorded as well. Salmonellae were shed at higher levels and for longer periods in the HZn group (P < 0.05), with no differences in the tissues. At 2 dpi, the relative percentages of CD4 ؉ T helper cells (P < 0.01) and of CD2 ؉ T and NK cells (P < 0.01) in blood were reduced from the relative cell counts obtained at 0 dpi, irrespective of the Zn group. The lowest percentage of cytotoxic T cells was found 14 dpi in the HZn group relative to the MZn (P < 0.05) and LZn (P < 0.01) groups. Supplementation of the feed with 2,500 mg Zn/kg of diet immediately after weaning could positively affect the immune responses of piglets infected with Salmonella Typhimurium, but for a short period only. After 2 weeks, all positive effects disappeared, and rather negative effects, such as higher shedding of salmonellae, lower T cell frequencies, and worse performance, occurred. Thus, supplementation with ZnO at high levels in the pig industry should be limited to 2 to 3 weeks.

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“…DQ018382). The dfrA12-orfF-aadA2 region of class 1 integrons was also found in Salmonella Choleraesuis isolated from human and swine (Hsu et al, 2006). The SGI1 was also found in Salmonella Typhimurium and Salmonella Derby .…”

Section: Discussionmentioning

confidence: 92%

“…The widespread distribution of the integrons and SGI1 among numerous serotypes and across several distinct geographical regions indicated clearly that antimicrobial drug resistance genes in the integrons or SGI1 able to move Chang et al 3911 from strain to strain. Transfer of plasmids with class 1 integrons or SGI1 between bacterial isolates documented (Hsu et al, 2006;Boyd et al, 2008;Leverstein-van Hall et al, 2002;Doublet et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Salmonella genomic island 1 and class 1 integron in Salmonella isolates from stray dogs

Chang¹,

Chuang²,

Chiu³

et al. 2011

Afr. J. Microbiol. Res.

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Characterisation of antimicrobial resistance patterns and class 1 integrons among Escherichia coli and Salmonella enterica serovar Choleraesuis strains isolated from humans and swine in Taiwan

Cited by 66 publications

References 40 publications

Susceptibilities to Antimicrobials and Disinfectants in Salmonella Isolates Obtained from Poultry and Swine in Thailand

Susceptibilities to Antimicrobials and Disinfectants in Salmonella Isolates Obtained from Poultry and Swine in Thailand

No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104

Salmonella genomic island 1 and class 1 integron in Salmonella isolates from stray dogs

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