Characterisation of Anopheles gambiae heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction

Spencer, Christopher S.; Yunta, Cristina; Lima, Glauber Pacelli Gomes de; Hemmings, Kay; Lian, Lu‐Yun; Lycett, Gareth; Paine, Mark J. I.

doi:10.1016/j.ibmb.2018.04.010

Cited by 12 publications

(16 citation statements)

References 59 publications

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“…[135,136] Enhances immune response to Plasmodium parasite Phenylalanine-4-hydroxylase a (PAH) [196] Genetic modification: development of refractory mosquitoes with increased expression of proteins post blood-feeding Nitric oxide synthase b (NOS) [170,172] Enhances Plasmodium parasite development or negative regulator of immune response Carboxypeptidase a [143] Transmission-blocking agents: inhibition of proteins provides transmission-blocking strategies. Carboxypeptidase can be already targeted using antibodies [143] Kynurenine 3-monooxygenase a [179] 3-hydroxykynurenine transaminase a [189] Ornithine decarboxylase a [200] Aquaporin 3 [178] Trehalose transporter c [177] Catalase b [158] Vitellogenin d [5] Lipophorin d [5] Apolipophorin d [181,182] Fecundity Phenylalanine-4-hydroxylase (PAH) a [196] Sterilants: inhibition may offer sterilizing strategies Ornithine decarboxylase a [197] Heme oxygenase [6] Vitellogenin d [5] Catalase b [204] Energy production during flight Trehalase c [156] Flight inhibitors: inhibition may provide flight inhibition strategies Pyrroline-5-carboxylate reductase a [144] Proline oxidase a [144] Insecticide resistance Cytochrome P450 monooxygenases e [238] Synergists: inhibitors may reverse insecticide resistance Glutathione S-transferases e [238] Survival or development of mosquitoes Aquaporin 3 [178] Insecticides: inhibitors may act as insecticides Catalase b [159] 3-hydroxykynurenine transaminase a [189] Carbonic anhydrase [52] Arylalkylamine N-acetyltransferases [51] Chorion peroxidase [207] V-ATPases [218...…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 13% of the heme contained in ingested blood is incorporated into the mosquito as follows: 7% into tissues of the adult mosquito and 6% into its eggs [203]. Spencer et al [6] reported that the consumption of heme oxygenase inhibitors such as zinc protoporphyrin (ZnPP) and tin protoporphyrin (SnPP) by An. gambiae remarkably decreased egg-laying.…”

Section: Role Of Metabolic Proteins In Fecunditymentioning

confidence: 99%

“…gambiae remarkably decreased egg-laying. They noted that inhibition of heme oxygenase increased sterility by preventing oviposition (laying of eggs), consequently culminating in reduced availability of vectors for malaria transmission [6]. So, the inhibition of heme oxygenase may be further studied for its sterilizing effect for mosquito population suppression.…”

Section: Role Of Metabolic Proteins In Fecunditymentioning

confidence: 99%

“…This blood meal is crucial for oogenesis [5]. Hence, Anopheles mosquito's ability to transmit malaria is directly linked to its ability to feed on and digest a blood meal from a malaria-infected person [6]. These processes i.e.…”

Section: Introductionmentioning

confidence: 99%

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Anopheles metabolic proteins in malaria transmission, prevention and control: a review

et al. 2020

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The increasing resistance to currently available insecticides in the malaria vector, Anopheles mosquitoes, hampers their use as an effective vector control strategy for the prevention of malaria transmission. Therefore, there is need for new insecticides and/or alternative vector control strategies, the development of which relies on the identification of possible targets in Anopheles. Some known and promising targets for the prevention or control of malaria transmission exist among Anopheles metabolic proteins. This review aims to elucidate the current and potential contribution of Anopheles metabolic proteins to malaria transmission and control. Highlighted are the roles of metabolic proteins as insecticide targets, in blood digestion and immune response as well as their contribution to insecticide resistance and Plasmodium parasite development. Furthermore, strategies by which these metabolic proteins can be utilized for vector control are described. Inhibitors of Anopheles metabolic proteins that are designed based on target specificity can yield insecticides with no significant toxicity to non-target species. These metabolic modulators combined with each other or with synergists, sterilants, and transmission-blocking agents in a single product, can yield potent malaria intervention strategies. These combinations can provide multiple means of controlling the vector. Also, they can help to slow down the development of insecticide resistance. Moreover, some metabolic proteins can be modulated for mosquito population replacement or suppression strategies, which will significantly help to curb malaria transmission.

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Section: Discussionmentioning

confidence: 99%

Section: Role Of Metabolic Proteins In Fecunditymentioning

confidence: 99%

Section: Role Of Metabolic Proteins In Fecunditymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anopheles metabolic proteins in malaria transmission, prevention and control: a review

et al. 2020

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“…Heme degradation comprises another control mechanism described in hematophagous [83,92]. The heme oxygenase (HO) enzyme catalyzes the heme oxidation into biliverdin, carbon monoxide (CO) and Fe 2+ , an oxygen and NADPH dependent reaction [40].…”

Section: Hematophagousmentioning

confidence: 99%

Control of Redox Homeostasis in Tick Blood Feeding

Sabadin¹,

Xavier²,

Vaz³

2019

Acta Scientiae. Vet.

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Introduction:Ticks are hematophagous ectoparasites that cause significate economical losses. Acaricide application is the main method to tick control. However, it causes environmental contamination and selects resistant ticks. The immunological control represents a suitable method to replace or complement acaricide application. During its life cycle, female ticks ingest large amounts of blood, which contains toxic components able to damage biomolecules. Understanding which molecular mechanisms and proteins are involved in avoid damages caused by blood intake in ticks and other hematophagous arthropods could help to found potential candidate antigens to compose an anti-tick vaccine. Review: Hemoglobin comprises almost 20% of mammalian blood proteins, its hydrolysis during tick digestion increases total free heme that can potentially generate reactive oxygen species (ROS), which easily oxidize lipids, proteins and DNA, modifying they structure and function. Lipids are more susceptible to high ROS levels. It can lead to membrane instability and cell death. Protein modifications caused by ROS can promote the protein loss of function and cell disturbance, however, it can also work as post-translational modifications, acting in cell signaling processes. DNA presents more efficient protective mechanisms against ROS, but damages can lead to double helix rupture. Oxidative stress is defined as a disturbance in the balance between the production and elimination of ROS, in favor of ROS production, leading to a disruption in redox homeostasis and/or molecular damage. Despite the well-recognized heme oxidative power and its already demonstrated cytotoxicity, ticks are able to feed on blood, controlling the redox homeostasis without causing oxidative stress. This occurs because ticks developed physiological adaptations to transport, store, metabolize and secrete toxic components from the diet. The strategies, such as heme compartmentalization in specialized organelles, and heme and iron carrying proteins are shared with most of other hematophagous. Interesting, heme degradation, a mechanism commonly described in hematophagous arthropods, showed to be absent in ticks. Moreover, there is a lack of key enzymes from the heme degradation pathway in tick genomes. As expected, antioxidant enzymes are often involved in homeostasis redox control. They act in a convenient way, eliminating physiological and non-physiological produced ROS. Despite their essential role in nonhematophagous organisms, antioxidant enzymes were associated with blood ingestion during arthropod hematophagous process, demonstrating their role in avoiding oxidative stress caused by blood intake. Catalase showed to be essential to heme detoxification in Rhipicephalus microplus tick, and diverse antioxidant enzymes are up-regulated after blood intake in a variety of hematophagous parasites. If in one hand ROS is responsible to cell damage and oxidative stress, on the other hand, several works revealed the fundamental role of ROS in cell signaling and function, demon...

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The Central Metabolism Model of Anopheles gambiae: A Tool for Understanding Malaria Vector Biology

Adedeji

Ogunlana

Fatumo

et al. 2023

Biotechnological Approaches to Sustainable Development Goals

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Characterisation of Anopheles gambiae heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction

Cited by 12 publications

References 59 publications

Anopheles metabolic proteins in malaria transmission, prevention and control: a review

Anopheles metabolic proteins in malaria transmission, prevention and control: a review

Control of Redox Homeostasis in Tick Blood Feeding

The Central Metabolism Model of Anopheles gambiae: A Tool for Understanding Malaria Vector Biology

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