Characterisation of Additively Manufactured Metallic Stents

Langi, Enzoh; Bisht, Anuj; Silberschmidt, Vadim V.; Ruiz, Pablo D.; Vogt, Felix; Mailto, Lucas; Masseling, Lukas; Zhao, Liguo

doi:10.1016/j.prostr.2019.07.008

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…These microstructural features can be very beneficial for tailoring and adjusting appropriate properties of metallic materials by LPBF. This was already shown for various corrosion-resistant biomaterials like Ti-based and CoCr-based alloys, Nitinol, or 316L stainless steel for, e.g., stent applications, porous structures for bone replacement, dental prostheses, or dental crowns and bridges. − However, the feasibility of the LPBF process for filigree structures utilized for stents using biodegradable alloys has yet to be intensively validated. The realization of favorable, very thin stent struts below 70 μm with conventional LPBF systems is crucial due to the size of the melting pool and semi-melted particles.…”

Section: Introductionmentioning

confidence: 99%

Cell–Material Interactions in Direct Contact Culture of Endothelial Cells on Biodegradable Iron-Based Stents Fabricated by Laser Powder Bed Fusion and Impact of Ion Release

Paul

Lode

Placht

et al. 2021

ACS Appl. Mater. Interfaces

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Additive manufacturing is a promising technology for the fabrication of customized implants with complex geometry. The objective of this study was to investigate the initial cell−material interaction of degradable Fe-30Mn-1C-0.02S stent structures in comparison to conventional 316L as a reference, both processed by laser powder bed fusion. FeMn-based alloys have comparable mechanical properties with clinically applied AISI 316L for a corrosion-resistant stent material. Different corrosion stages of the as-built Fe-30Mn-1C-0.02S stent surfaces were simulated by pre-conditioning in DMEM under cell culture conditions for 2 h, 7 days, and 28 days. Human umbilical vein endothelial cells (HUVECs) were directly seeded onto the pre-conditioned samples, and cell viability, adherence, and morphology were analyzed. These studies were accompanied by measurements of iron and manganese ion release and Auger electron spectroscopy to evaluate the influence of corrosion products and degradation on the cells. In the initial phase (2 h of preconditioning), HUVECs were able to attach but the cell number decreased over the cultivation period of 14 days and the CD31 staining pattern of intercellular contacts was disordered. At later time points of corrosion (7 and 28 days of pre-conditioning), CD31 staining was distinctly located at the intercellular contacts, and the cell density increased after seeding and was stable for up to 14 days. Formation of a complex degradation layer, which had a composition and thickness dependent on the pre-conditioning time, led to a reduced ion release and finally showed a positive effect on cell survival. Concluding, our data suggest the suitability of Fe-30Mn-1C-0.02S for in vivo applications.

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Section: Introductionmentioning

confidence: 99%

Cell–Material Interactions in Direct Contact Culture of Endothelial Cells on Biodegradable Iron-Based Stents Fabricated by Laser Powder Bed Fusion and Impact of Ion Release

Paul

Lode

Placht

et al. 2021

ACS Appl. Mater. Interfaces

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“…Balloon-expandable stents, unlike the self-expanding stents, experience large plastic deformations resulting in their self-hardening [ 14 , 15 ]. Such stents are usually made from stainless steel or cobalt-chrome-based alloys [ 16 , 17 ]. Some authors [ 17 , 18 , 19 , 20 , 21 ] suggest using pure iron, magnesium, and zinc alloys, as well as poly-L-lactic acid biopolymer for stents, as these materials are able to degrade and resorb in the body after implantation.…”

Section: Introductionmentioning

confidence: 99%

“…Such stents are usually made from stainless steel or cobalt-chrome-based alloys [ 16 , 17 ]. Some authors [ 17 , 18 , 19 , 20 , 21 ] suggest using pure iron, magnesium, and zinc alloys, as well as poly-L-lactic acid biopolymer for stents, as these materials are able to degrade and resorb in the body after implantation. The focus of this paper is on balloon-expandable stents, as they are more commercially available.…”

Section: Introductionmentioning

confidence: 99%

Inelastic Deformation of Coronary Stents: Two-Level Model

et al. 2022

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This study describes the internal structure of materials used to produce medical stents. A two-level elastoviscoplastic mathematical model, which sets the parameters and describes the processes at the grain level, was developed and numerically implemented. A separate study was conducted to identify the most dangerous deformation modes in the balloon-expandable stent placement using the finite-element method in COMSOL Multiphysics. As a result, the challenging strain state type required for setting the kinematic loading on a representative macrovolume in the two-level model was obtained. A yield surface for different deformation paths in the principal deformation space for stainless steel AISI 316L was obtained and the effect of grain size on the deformation behavior of this material was explored using the developed model.

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Additive manufacturing of vascular stents

Shi

et al. 2023

Acta Biomaterialia

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Characterisation of Additively Manufactured Metallic Stents

Cited by 5 publications

References 9 publications

Cell–Material Interactions in Direct Contact Culture of Endothelial Cells on Biodegradable Iron-Based Stents Fabricated by Laser Powder Bed Fusion and Impact of Ion Release

Cell–Material Interactions in Direct Contact Culture of Endothelial Cells on Biodegradable Iron-Based Stents Fabricated by Laser Powder Bed Fusion and Impact of Ion Release

Inelastic Deformation of Coronary Stents: Two-Level Model

Additive manufacturing of vascular stents

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