Characterisation and drug release performance of biodegradable chitosan–graphene oxide nanocomposites

Justin, Richard; Chen, Biqiong

doi:10.1016/j.carbpol.2013.12.012

Cited by 182 publications

(102 citation statements)

References 72 publications

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“…Similar pH-sensitive drug release behavior was previously reported for GO-poly(vinyl alcohol) hydrogels, 26 chitosan-functionalized GO nanosheets, 31,32 dry chitosan-GO nanocomposites, 30 and dry chitosan-reduced GO nanocomposites. 75 The diffusion of the encapsulated drug in an acidic solution is unfavorable because GO sheets tend to form tightly packed aggregates.…”

Section: Ph-sensitive Drug Release Behaviorsupporting

confidence: 78%

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Self‐assembled graphene oxide–gelatin nanocomposite hydrogels: Characterization, formation mechanisms, and pH‐sensitive drug release behavior

Piao

Chen

2014

J Polym Sci B Polym Phys

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Novel physically crosslinked graphene oxide (GO)-gelatin nanocomposite hydrogels were obtained by selfassembly. The hydrogels with various ratios of GO to gelatin were prepared, and characterized by X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, and scanning electron microscopy. The static and dynamic rheological properties of the hydrogels were investigated, along with the underlying hydrogel formation mechanisms. The storage modulus of the hydrogels (containing 98-98.5 wt % water) reached 114.5 kPa, owing to the relatively strong physical bonding (i.e., hydrogen bonding and electrostatic forces) between GO and gelatin. Drug release tests showed that the drug release from the hydrogel was pH-dependent, with 96% of the model drug released in a neutral environment, compared to 28% released in an acidic medium. These hydrogels could have potential in pH-sensitive drug delivery. V C 2014

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Section: Ph-sensitive Drug Release Behaviorsupporting

confidence: 78%

“…28 Similarly, small additions of GO enhanced the mechanical properties and drug delivery performance in dry and solid chitosan-GO nanocomposites. 29,30 In the form of nanosheet powder, gelatin-functionalized graphene nanosheets 18 and chitosanfunctionalized graphene nanosheets 31,32 were investigated for potential application as pH-sensitive drug carriers.…”

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confidence: 99%

Self‐assembled graphene oxide–gelatin nanocomposite hydrogels: Characterization, formation mechanisms, and pH‐sensitive drug release behavior

Piao

Chen

2014

J Polym Sci B Polym Phys

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“…Since 2 mL of 20 μg/mL EPI was exactly absorbed on 180 μL of 100 μg/mL PSSG, the MLC of PSSG to EPI can be calculated as the mass ratio of EPI to PSSG (40-18 μg). Therefore, for our drug carrier system, the MLC is 2.22 mg/mg, which is much higher than that of GO in the reported literatures (with corresponding values of 0.815, 43 1, 21 1.4 36 and 2 mg/mg, 22 respectively). This is mainly due to the π-π stacking …”

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confidence: 56%

“…27,36 The reduction degree of the PSS-functionalized GO was investigated using UV-vis ( Figure 3A) and FTIR spectroscopy ( Figure 3B). In Figure 3A, a strong absorption peak at 231 nm was observed in GO (curve c), which was attributed to π-π* transitions of C=C in aromatic ring.…”

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Preparation and tumor cell model based biobehavioral evaluation of the nanocarrier system using partially reduced graphene oxide functionalized by surfactant

Wang

Liu²,

Luo

2015

IJN

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Background Currently, surfactant-functionalized nanomaterials are tending toward development of novel tumor-targeted drug carriers to overcome multidrug resistance in cancer therapy. Now, investigating the biocompatibility and uptake mechanism of specific drug delivery systems is a growing trend, but usually a troublesome issue, in simple pharmaceutical research. Methods We first reported the partially reduced graphene oxide modified with poly(sodium 4-styrenesulfonate) (PSS) as a nanocarrier system. Then, the nanocarrier was characterized by atomic force microscope, scanning electron microscope, high-resolution transmission electron microscope, ultraviolet–visible (UV-vis) spectroscopy, Fourier transform infrared spectroscopy, X-Ray powder diffraction, and Raman spectroscopy. Epirubicin (EPI) was attached to PSSG via π–π stacking, hydrogen bonding, and physical absorption to form conjugates of PSSG–EPI. The adsorption and desorption profiles, cytotoxicity coupled with drug accumulation, and uptake of PSSG and PSSG–EPI were evaluated. Finally, the subcellular behaviors, distribution, and biological fate of the drug delivery system were explored by confocal laser scanning microscope using direct fluorescence colocalization imaging and transmission electron microscopy. Results The partially reduced graphene oxide sheets functionalized by surfactant exhibit good dispersibility. Moreover, due to much less carboxyl groups retained on the edge of PSSG sheets, the nanocarriers exhibit biocompatibility in vitro. The obtained PSSG shows a high drug-loading capacity of 2.22 mg/mg. The complexes of PSSG–EPI can be transferred to lysosomes in 2 hours through endocytosis, then the drug is released in the cytoplasm in 8 hours, and ultimately EPI is delivered into cell nucleus to exhibit medicinal effects in 1 day. Conclusion The comprehensive exploration of the biological uptake mechanism of functional graphene-mediated tumor cell targeting model provides a typical protocol for evaluation of drug delivery system and will benefit the discovery of new surfactant-modified nanocarriers in nanomedicine.

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Mechanical Properties of Natural Biopolymer Nanocomposites

Chen¹

2017

Bionanocomposites

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Characterisation and drug release performance of biodegradable chitosan–graphene oxide nanocomposites

Cited by 182 publications

References 72 publications

Self‐assembled graphene oxide–gelatin nanocomposite hydrogels: Characterization, formation mechanisms, and pH‐sensitive drug release behavior

Self‐assembled graphene oxide–gelatin nanocomposite hydrogels: Characterization, formation mechanisms, and pH‐sensitive drug release behavior

Preparation and tumor cell model based biobehavioral evaluation of the nanocarrier system using partially reduced graphene oxide functionalized by surfactant

Mechanical Properties of Natural Biopolymer Nanocomposites

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