Chapter VIII The nitric oxide system in the urogenital tract

Davidoff, M; Middendorff, Ralf

doi:10.1016/s0924-8196(00)80062-7

Cited by 5 publications

(1 citation statement)

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“…Similar to M2 and M3 (and M1) muscarinic acetylcholine receptors (mAChR) shown to be involved in cilia-driven transport in the airways (Klein et al 2009), cholinergic contribution to the transport of spermatozoa is also thinkable, since M2, M3 (and M1) mAChRs were also described in ciliated cells of the efferent ducts (Siu et al 2006). In addition, the presence of NOS in ciliated cells suggests that NO also could have an impact on sperm transport (Davidoff & Middendorff 2000).…”

Section: Transport Effects By Kinociliamentioning

confidence: 99%

Contractility of the epididymal duct - function, regulation and potential drug effects

et al. 2018

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During their transit through the epididymis, spermatozoa mature and acquire motility and fertilizing capacity. The smooth muscle cells (SMCs) of the epididymal duct are thought to be responsible for the adequate transport of spermatozoa. Thus, precise regulation of SMC function also represents a prerequisite for sperm maturation thereby contributing to male fertility. In this review we would like to highlight various aspects of epididymal SMC function and discuss several angles with respect to regulation of contraction and relaxation. Different to the vas deferens, where disturbed SMC pathways resulting in male infertility could be defined, comparable information is missing in the epididymis. We therefore include some vas deferens data which could also be useful for a better understanding of epididymal SMC function. Furthermore, we would like to draw attention to drugs used in clinical practice and their potential (side) effects on contractions in the epididymis.

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Section: Transport Effects By Kinociliamentioning

confidence: 99%