Chapter II.5.2 – Nonthrombogenic Treatments and Strategies

Sefton, Michael V.; Gemmell, Cynthia H.; Gorbet, Maud

doi:10.1016/b978-0-08-087780-8.00155-8

Cited by 4 publications

(6 citation statements)

References 140 publications

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“…[ 8 ] Moreover, surface properties (roughness, hydrophilicity, low fouling toward biological molecules) are directly related to immune response and blood coagulation activation. [ 9 ] Despite these advances, several challenges for the use of conventional PLA fi brous mesh remain to be addressed. One such challenge is their hydrophobic surface, which causes nonspecifi c interactions with proteins in the blood.…”

Section: Resultsmentioning

confidence: 99%

Air‐Spun PLA Nanofibers Modified with Reductively Sheddable Hydrophilic Surfaces for Vascular Tissue Engineering: Synthesis and Surface Modification

Sabbatier

Cunningham

et al. 2013

Macromol. Rapid Commun.

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Polylactide (PLA) is a class of promising biomaterials that hold great promise for various biological and biomedical applications, particularly in the field of vascular tissue engineering where it can be used as a fibrous mesh to coat the inside of vascular prostheses. However, its hydrophobic surface providing nonspecific interactions and its limited ability to further modifications are challenges that need to be overcome. Here, the development of new air-spun PLA nanofibers modified with hydrophilic surfaces exhibiting reduction response is reported. Surface-initiated atom transfer radical polymerization allows for grafting pendant oligo(ethylene oxide)-containing polymethacrylate (POEOMA) from PLA air-spun fibers labeled with disulfide linkages. The resulting PLA-ss-POEOMA fibers exhibit enhanced thermal stability and improved surface properties, as well as thiol-responsive shedding of hydrophilic POEOMA by the cleavage of its disulfide linkages in response to reductive reactions, thus tuning the surface properties.

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Section: Resultsmentioning

confidence: 99%

Air‐Spun PLA Nanofibers Modified with Reductively Sheddable Hydrophilic Surfaces for Vascular Tissue Engineering: Synthesis and Surface Modification

Sabbatier

Cunningham

et al. 2013

Macromol. Rapid Commun.

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“…Yet, with a sol‐gel transition temperature below 37°C as well as decreasing mechanical stability and elasticity as a result of swelling effects, the applicability of pure gelatin is limited. However, modifications and functionalization can increase the potential for applications in physiological environments …”

Section: Introductionmentioning

confidence: 99%

“…However, modifications and functionalization can increase the potential for applications in physiological environments. 8 For usage as cellular substrates, hydrogel surfaces are often functionalized with proteins and polymers to improve and promote cell-surface interactions. Cells perceive and react to various biochemical and biophysical signals from the microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Micropatterning of reagent‐free, high energy crosslinked gelatin hydrogels for bioapplications

et al. 2017

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Hydrogels are crosslinked polymeric gels of great interest in the field of tissue engineering, particularly as biocompatible cell or drug carriers. Reagent-free electron irradiated gelatin is simple to manufacture, inexpensive and biocompatible. Here, the potential to micropattern gelatin hydrogel surfaces during electron irradiation crosslinking was demonstrated as a promising microfabrication technique to produce thermally stable structures on highly relevant length scales for bioapplications. In the present work, grooves of 3.75 to 170 mm width and several hundred nanometers depth were transferred onto gelatin hydrogels during electron irradiation and characterized by 3D confocal microscopy after exposure to ambient and physiological conditions. The survival and influence of these microstructures on cellular growth was further characterized using NIH 3T3 fibroblasts. Topographical modifications produced surface structures on which the cultured fibroblasts attached and responded by adapting their morphologies. This developed technique allows for simple and effective structuring of gelatin and opens up new possibilities for irradiation crosslinked hydrogels in biomedical applications in which cell attachment and contact guidance are favored.

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“…The PLL-PEG surface was modified using tripeptide Arg-Gly-Asp (RGD) protein sequence that was responsible for binding proteins to cell surfaces. The goal of the RGD incorporation onto the surface was to promote the cell growth on the hydrophilic PEG containing surfaces [32]. In the other papers we suggested the solution enabling the stabilization of the porous coating using silicon nanoparticles [34,35].…”

Section: Porous Extracellular-like Coatingsmentioning

confidence: 99%

“…In addition, as a step to prepare the substrate surface for applying the porous coating, the haemocompatibile ultrathin coating were previously deposited. Following information given elsewhere [32,33], the nonthrombogenic surface for vascular grafts/artificial hearts was prepared in order to consist an intact luminal endothelial cell layer. Porous materials like poly-L-lysine polyethylene glycol and hyaluronic acid (PLL-PEG/HA) in the form of porous coatings were the key issue.…”

Section: Porous Extracellular-like Coatingsmentioning

confidence: 99%

Bio-Inspiered Blood-Contacting Materials Elaborated For The Heart Assist System

Major¹

2015

Archives of Metallurgy and Materials

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I dedicate this work to my Father, who is also my Mentor.He has enabled me to execute my professional passion.The paper presents the main achievements of the author on the development of blood contacting materials. The main objective of the work is to elaborate materials dedicated for the heart support systems. Appropriately designed biomaterial surfaces enable fully controlled cellular differentiation, proliferation, and even restoration of the tissue structure on solids. The paper presents two approaches to modify the surface, which can control the life processes of tissue. The first solution considers the topography in the form of cell niches. The main objective of the study is a modified surface of thin films deposited on the polymer substrate constituting the microenvironment for the cells caused by residual stress and optimized stiffness of the surface using the plasma methods. The research hypothesis was the plasma surface modification method generating a controlled contribution of residual stress in the coating affect the surface topography in the form of nano-wrinkles similar to the niches in the tissue environment. Topography and stiffness of the surface coating allows the targeted cellular differentiation. The properly formed surface topography effectively inhibits blood clotting processes. The second solution considers implementation of self-organizing feature of extracellular matrix like coatings and selective cell mobilization. The multiscale analysis and phenomenologic description were performed to experimental research. For this purpose, the deposition method was based on electrostatic interactions in polyelectrolytes. This type of cell-polymer structure imitate the native structures.Keywords: Surface modification, cell-material interaction, tissue precursors, materials for regenerative medicine Praca przedstawia najważniejsze osiągniecia autora dotyczące rozwoju materiałów do kontaktu z krwią. Głównym celem prowadzonych prac są materiały o przeznaczeniu w komorach wspomagania serca. Odpowiednio zaprojektowana powierzchnia biomateriału umożliwia w pełni kontrolowane różnicowanie komórkowe, proliferację i nawet odtworzenie struktury tkanki na ciele stałym. W pracy przedstawiono dwa podejścia modyfikacji powierzchniowej, które pozwalają sterować procesami życio-wymi tkanki. Pierwszym rozwiązaniem są powłoki o topografii nisz komórkowych. Celem głównym badań jest zmodyfikowana powierzchnia materiałów cienkowarstwowych nałożonych na podłoże polimerowe stanowiąca mikrośrodowisko dla wychwytu i kontrolowanego różnicowania komórek uzyskane przez odpowiedni udział naprężeń własnych i zoptymalizowaną sztywność powierzchniową. Ukierunkowana mikrostrukturą i właściwościami powierzchniowymi monowarstwa hamuje procesy wykrzepiania krwi. Drugie rozwiązanie dotyczy powłok o strukturze macierzy zewnątrzkomórkowej. Celem badań jest wieloskalowa analiza i opis fenomenologiczny samoorganizujących się powłok z funkcją selektywnej mobilizacji komórkowej. Jest to nowoczesne podejście na poziomie badań eksperymentalnyc...

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Chapter II.5.2 – Nonthrombogenic Treatments and Strategies

Cited by 4 publications

References 140 publications

Air‐Spun PLA Nanofibers Modified with Reductively Sheddable Hydrophilic Surfaces for Vascular Tissue Engineering: Synthesis and Surface Modification

Air‐Spun PLA Nanofibers Modified with Reductively Sheddable Hydrophilic Surfaces for Vascular Tissue Engineering: Synthesis and Surface Modification

Micropatterning of reagent‐free, high energy crosslinked gelatin hydrogels for bioapplications

Bio-Inspiered Blood-Contacting Materials Elaborated For The Heart Assist System

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