CHAPTER 8. Bioactive Conducting Polymers for Optimising the Neural Interface

Goding, Josef; Green, Rylie A.; Martens, Penny J.; Poole‐Warren, Laura

doi:10.1039/9781782628453-00192

Cited by 1 publication

(2 citation statements)

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“…[27,[37][38][39] However, continued issues with low conductivity have hindered translation of CHs into biomedical applications. [24,40,41] In the last decade, poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) has dominated the CP field, due to its excellent electrical properties, chemical and thermal stability and low oxidation potential. [24,25] However, despite the promise of CPs as attractive materials for in vitro models of functional brain tissue, challenges with their use continue to hinder widespread application in tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

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An Electroactive Oligo‐EDOT Platform for Neural Tissue Engineering

Ritzau‐Reid

Spicer

Gelmi

et al. 2020

Adv Funct Materials

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The unique electrochemical properties of the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4-ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end-capping strategy, into block co-polymers. By exploiting end-functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co-polymer is produced that is electroactive, processable, and bio-compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.

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