Chapter 6 The Neuroanatomy of Atypical Handedness in Schizophrenia

Satz, Paul; Green, Michael Foster; Ganzell, Steven; Bartzokis, George; Bledin, Anthony G.; Vaclav, Joseph F.

doi:10.1016/s0166-4115(08)61247-9

Cited by 2 publications

(4 citation statements)

References 46 publications

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“…Moreover, strongly nondextral subjects were not clearly distinguishable from those with intermediate (possibly ambiguous) degrees of handedness. The results thus failed to support the concept that ambiguous handedness comprises an index of especially severe neurodevelopmental compromise (Satz et al, in press). Because our sample had relatively few nondextral patients with family history of nondextrality or with strong nondextrality, the failure to detect effects on IQ scores may simply reflect a lack of statistical power.…”

Section: Discussionmentioning

confidence: 70%

Intellectual Deficits in First-Episode Schizophrenia: Evidence for Progressive Deterioration

Bilder

Lipschutz-Broch

Reiter

et al. 1992

Schizophrenia Bulletin

266

113

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The developmental processes leading to neuropsychological deficits in schizophrenia are poorly understood. Both early developmental defects and subsequent deterioration may occur. Intelligence test profiles are often used to estimate premorbid ability and deterioration from prior levels of functioning. These characteristics were assessed in samples of first-episode (n = 51) and chronic (n = 50) schizophrenic patients. Although the groups showed few differences on tests to estimate premorbid intellectual ability, the chronic group performed worse on measures considered sensitive to deterioration. Dextral (right-handed) patients tended to have better performance; this effect was marked in the first-episode sample, especially on verbal tests. Male patients showed more evidence of deterioration than female patients. Subgroups differing in the time course of premorbid social dysfunction also differed in intelligence test profiles, suggesting that estimates of social and cognitive deterioration may have concurrent validity. The results support the hypothesis that patients differ in the course of cognitive decline and suggest that deterioration of function may follow the onset of overt psychosis in some patients. Prospective longitudinal studies of first-episode schizophrenic patients could directly test this hypothesis.

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Section: Discussionmentioning

confidence: 70%

Intellectual Deficits in First-Episode Schizophrenia: Evidence for Progressive Deterioration

Bilder

Lipschutz-Broch

Reiter

et al. 1992

Schizophrenia Bulletin

266

113

View full text Add to dashboard Cite

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“…As mentioned earlier, several studies have found an association between handedness and increased VBRs in schizophrenia (Katsanis and Iacono 1989; Pearlson et al 1989; Satz et al 1990; Clementz et al 1994). It would be reasonable to expect that the relationships between atypical handedness and neuroanatomy would be mirrored by associations between handedness and neurocognition.…”

Section: Are There Clinical and Cognitive Correlates Of Atypical Hand...mentioning

confidence: 73%

“…The fifth study (Satz et al 1990), reported MRI data on a small sample of lateralized ( n = 25) and nonlateral ized ( n = 10) chronic schizophrenia patients using the HPDT, in which the lateralized group was classified based on consistent preference in the same direction (right in all but one patient) for all tasks across repeated presentations. The MRI scans were also compared with those from a normal control group ( n = 25).…”

Section: Atypical Handedness: Is There a Shift In The Distribution?mentioning

confidence: 99%

“…Five of these studies also reported data on prevalence, as noted earlier in this review (Clementz et al 1994; Manoach 1994; Cannon et al 1995; O’Callaghan et al 1995; Taylor and Amir 1995). The remaining studies were Katsanis and Iacono 1989; Pearlson et al 1989; Barr et al 1990; Joseph 1990; Satz et al 1990; Faustman et al 1991; Kern et al 1991; Brown et al 1992; Tyler et al 1995; Manschreck et al 1996; Morgenstern et al 1996; Hayden et al 1997. Most of these studies were not addressed in the original review by Green et al (1989 b ) because of its focus on assessment methodology and prevalence.…”

Section: Are There Clinical and Cognitive Correlates Of Atypical Hand...mentioning

confidence: 99%

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Atypical Handedness in Schizophrenia: Some Methodological and Theoretical Issues

Satz¹,

Green²

1999

Schizophrenia Bulletin

117

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An updated review of the literature strongly supports the view that in schizophrenia there is an atypical leftward shift in the handedness distribution that, while comprising different subtypes, is characterized by a more variable and less completely lateralized pattern of manual preference, referred to as mixed handedness (MH) or ambiguous handedness (AH). Only two studies revealed an increased prevalence of left-handedness suggestive of pathological left-handedness (PLH). This article also examines the current status of neurodevelopmental factors and mechanisms in schizophrenia that purport to explain these pathological shifts in handedness (PLH, MH, AH). Different theoretical positions were evaluated, each involving some aspect of left hemisphere insult (unilateral or bilateral). Finally, it was shown that these shifts predict certain key symptoms and neural substrates in schizophrenia including thought disorder, negative symptoms, neuropsychological impairment, family history, and brain anatomy. These subtypes may represent neurodevelopmental markers of insult during intrauterine life that are nongenetic in origin.

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Chapter 6 The Neuroanatomy of Atypical Handedness in Schizophrenia

Cited by 2 publications

References 46 publications

Intellectual Deficits in First-Episode Schizophrenia: Evidence for Progressive Deterioration

Intellectual Deficits in First-Episode Schizophrenia: Evidence for Progressive Deterioration

Atypical Handedness in Schizophrenia: Some Methodological and Theoretical Issues

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