Chapter 6.2: Six-Membered Ring Systems: Diazines and Benzo Derivatives

Manlove, Amelia H.; Groziak, Michael P.

doi:10.1016/s0959-6380(09)70040-6

Cited by 21 publications

(9 citation statements)

References 363 publications

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“…Also in the family of heterocyclic compounds nitrogen containing heterocycles are an important class of compounds in the medicinal chemistry and also contributed to the society from biological and industrial point which helps to understand life processes [ 25 ]. A totally unsaturated membered six-ring containing nitrogen is known as azine [ 26 ] or pyridine ( 1 ); with two nitrogen atoms it is known as diazine [ 27 ], and with a nitrogen at 1,2-position, it is known as pyridine ( 2 ), at 1,3-position as pyrimidine ( 3 ), and at 1,4-position as pyrazine ( 4 ) ( Figure 1 ). However, the current review intends to focus on the significance of pyrimidine class of antimicrobial agents along with clinical and in vitro applications of pyrimidine derivatives to facilitate the development of more potent as well as effective antimicrobial agents.…”

Section: Introductionmentioning

confidence: 99%

Significance and Biological Importance of Pyrimidine in the Microbial World

Sharma

Chitranshi

Agarwal

2014

International Journal of Medicinal Chemistry

203

160

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Microbes are unique creatures that adapt to varying lifestyles and environment resistance in extreme or adverse conditions. The genetic architecture of microbe may bear a significant signature not only in the sequences position, but also in the lifestyle to which it is adapted. It becomes a challenge for the society to find new chemical entities which can treat microbial infections. The present review aims to focus on account of important chemical moiety, that is, pyrimidine and its various derivatives as antimicrobial agents. In the current studies we represent more than 200 pyrimidines as antimicrobial agents with different mono-, di-, tri-, and tetrasubstituted classes along with in vitro antimicrobial activities of pyrimidines derivatives which can facilitate the development of more potent and effective antimicrobial agents.

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Section: Introductionmentioning

confidence: 99%

Significance and Biological Importance of Pyrimidine in the Microbial World

Sharma

Chitranshi

Agarwal

2014

International Journal of Medicinal Chemistry

203

160

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“…8 In contrast, the lone electron pairs of nitrogen atoms of pyrimidine and triazine are in the equatorial position to the ring that constrains them from being involved in π-conjugation and causes the appearance of partly positive charges on carbon atoms. 9,10 This makes them favorable acceptor constituents in the design of donor−acceptor (D−A)-type electroactive compounds. Moreover, in nitrogen-containing heterocycles, triplet states with nπ* character are present, which facilitates intersystem crossing, thus increasing the intensity of delayed fluorescence.…”

Section: ■ Introductionmentioning

confidence: 99%

Effects of Electron-Withdrawing Strengths of the Substituents on the Properties of 4-(Carbazolyl-R-benzoyl)-5-CF₃-1H-1,2,3-triazole Derivatives as Blue Emitters for Doping-Free Electroluminescence Devices

Stanitska,

Pokhodylo,

Lytvyn

et al. 2024

ACS Omega

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The synthesis of four 4-(carbazolyl-R-benzoyl)-5-CF 3 -1H-1,2,3-triazoles with extra groups ((3-methyl)-phenyl-, 4fluorophenyl-, quinolinyl-, or (3-trifluoromethyl)-phenyl-) in the acceptor fragment has been reported. The effects of substituents with different electron-withdrawing strengths on the thermal, electrochemical, photophysical, and electroluminescence properties of the synthesized compounds are discussed. The results of X-ray analyses and density functional theory (DFT) calculations support unusual molecular packing and electronic properties. The compounds are capable of glass formation with glass transition temperatures ranging from 54−84 °C. Ionization potentials of the compounds are in the range of 5.98−6.22 eV and electron affinities range from 3.09 to 3.35 eV. Under ultraviolet excitation, the neat films of the compounds exhibit blue emission with photoluminescence quantum yields ranging from 18 to 27%. The films of selected compounds are used for the preparation of host-free light-emitting layers of organic light-emitting diodes with very simple device structures and an external quantum efficiency of 4.6%.

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“…The reactivities of 2,4,5 and 6 carbon atoms, as well as substituents attached to them, vary individually. Although the parent compound, pyrimidine is not widely used, many of its derivatives are found in commercial products or in nature [1][2][3] (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Antimicrobial Activity of Pyrimidines: A Review

JADHAV¹,

BARAVKAR²

2021

Asian J Pharm Clin Res

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Over the past era, development of small heterocycles as potential therapeutics has been a zone of major interest. A large number of pyrimidine derivatives are of considerable biological and chemical interest. Pyrimidine derivatives have shown numerous biological activities such as antimicrobial, antitubercular, anticancer, anticonvulsant, antidiabetic, antiviral, and anti-inflammatory. Being a heterocyclic compound, Pyrimidine finds its use for designing synthesis of newer biologically active structures, as its aromaticity makes it relatively stable, also reactive sites which allow for functionalization. Several amino derivatives of nitrogen-containing heterocycles such as pyrimidine, pyridine possess an antimicrobial activity. In this review, recent advancements in the antimicrobial activity of pyrimidine derivatives have been reported.

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Chapter 6.2: Six-Membered Ring Systems: Diazines and Benzo Derivatives

Cited by 21 publications

References 363 publications

Significance and Biological Importance of Pyrimidine in the Microbial World

Significance and Biological Importance of Pyrimidine in the Microbial World

Effects of Electron-Withdrawing Strengths of the Substituents on the Properties of 4-(Carbazolyl-R-benzoyl)-5-CF₃-1H-1,2,3-triazole Derivatives as Blue Emitters for Doping-Free Electroluminescence Devices

Recent Advances in Antimicrobial Activity of Pyrimidines: A Review

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Chapter 6.2: Six-Membered Ring Systems: Diazines and Benzo Derivatives

Cited by 21 publications

References 363 publications

Significance and Biological Importance of Pyrimidine in the Microbial World

Significance and Biological Importance of Pyrimidine in the Microbial World

Effects of Electron-Withdrawing Strengths of the Substituents on the Properties of 4-(Carbazolyl-R-benzoyl)-5-CF3-1H-1,2,3-triazole Derivatives as Blue Emitters for Doping-Free Electroluminescence Devices

Recent Advances in Antimicrobial Activity of Pyrimidines: A Review

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Effects of Electron-Withdrawing Strengths of the Substituents on the Properties of 4-(Carbazolyl-R-benzoyl)-5-CF₃-1H-1,2,3-triazole Derivatives as Blue Emitters for Doping-Free Electroluminescence Devices