Chapter 5 The Imidazole Alkaloids

Some Aspects of Guanidine Secondary Metabolites

“…Subsequently, WIESNER et al (738) proposed a monoterpenoid structure (594) for chaksine after further degradative studies. This proposal conformed with the IH-NMR studies reported later by the same group (739) and with X-ray diffraction of the ureido acid (595), a degradation product of chaksine (741).…”

Antibacterial, anti-inflammatory, anti-cholinesterase and mutagenic effects of extracts obtained from some trees used in South African traditional medicine

“…Alkaloids, tannins, lactones, triterpenoids and hydroxystilbene glycosides are found in Combretum and Terminalia species McGaw et al, 2000). Albilocin, flavonoids, acetylhistamine and imidazoleatic acid occur in Albizia adianthifolia (Maat and Beyerman, 1983) and limonoids are present in Trichilia species (Mulholland and Taylor, 1980). Tannins, ethyl galate and the flavonoids the octasanol, ␤-amyrine and ␣-betulin are present in Acacia species (Ayoub, 1984;Abdelnabi et al, 1992;Neuwinger, 1996), while ferulic esters, terpenoids, phytosterols and amygdalin occur in Prunus africana .…”

Detection of Novel Cytotoxic Imidazole Alkaloids in Tomato Products by LC-MS/MS

“…In comparison with the above-mentioned alkaloids, there are fewer reports on their occurrence, and a considerable part of imidazole alkaloids have been identified in marine organisms over the last few decades . The most popular representative of the imidazole alkaloids is undeniably pilocarpine, which was first isolated from Pilocarpus jaborandi Holmes leaves and is known for its therapeutic use as a miotic agent and sialagogue . In general, the occurrence of imidazole alkaloids in plants has been primarily described in the genus Pilocarpus , belonging to the family Rutaceae .…”