Chapter 5 Biomarkers Related To Aging In Human Populations

Crimmins, Eileen M.; Vasunilashorn, Sarinnapha; Kim, Jung Ki; Alley, Dawn E.

doi:10.1016/s0065-2423(08)00405-8

Cited by 137 publications

(125 citation statements)

References 359 publications

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“…Aging is associated with increased concentration of circulating inflammatory markers, including inflammatory cytokines and fibrinolytic products. The concentration of some of these substances is associated with increased risk of death, functional dependence, and geriatric syndromes and may mirror the functional age of the person [16,38]. Cure and prolongation of survival are common goals at any age.…”

Section: Definition Of Agingmentioning

confidence: 99%

Anorexia, undernutrition, weight loss, sarcopenia, and cachexia of aging

Hao

Guo

2012

Eur Rev Aging Phys Act

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During the period between 2000 and 2030, the number of persons older than 65 years is projected to grow from 550 to 937 million worldwide. Globally, this growth represents an increase from 6.9 to 12 %. Studies have found that 74.6 % of women and 67.4 % of men aged 65 years or older suffer from many clinical and subclinical syndromes and problems, including anorexia, undernutrition, weight loss, sarcopenia, and cachexia, which are often overlooked or managed inadequately. These issues are very common in the elder. The key clinical question is whether these changes in the elder are distinct entities or an interdependent continuum. In this article, we reviewed these issues of related basic, clinical knowledge. The purpose of this review is to enhance the recognition of anorexia, undernutrition, weight loss, sarcopenia, and cachexia.

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Section: Definition Of Agingmentioning

confidence: 99%

Anorexia, undernutrition, weight loss, sarcopenia, and cachexia of aging

Hao

Guo

2012

Eur Rev Aging Phys Act

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“…There have been many studies of individual biomarkers as predictors of mortality in older people (Seeman et al 2004;Crimmins et al 2008). A number of prognostic indices for older adults living in the community have also been developed (Yourman et al 2012); however, these indices are all based on subjects' responses to questionnaires and use of administrative datasets but do not include the wider range of information that can be easily collected in a clinical setting.…”

Section: Introductionmentioning

confidence: 99%

Multiple, but not traditional risk factors predict mortality in older people: the concord health and ageing in men project

Hirani

Naganathan

Blyth

et al. 2014

AGE

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This study aims to identify the common risk factors for mortality in community-dwelling older men. A prospective population-based study was conducted with a median of 6.7 years of follow-up. Participants included 1705 men aged ≥70 years at baseline (2005)(2006)(2007) living in the community in Sydney, Australia. Demographic information, lifestyle factors, health status, self-reported history of diseases, physical performance measures, blood pressure, height and weight, disability (activities of daily living (ADL) and instrumental ADLs, instrumental ADLs (IADLs)), cognitive status, depressive symptoms and blood analyte measures were considered. Cox regression analyses were conducted to model predictors of mortality. During follow-up, 461 men (27 %) died. Using Cox proportional hazards model, significant predictors of mortality included in the final model (p<0.05) were older age, body mass index<20 kg m 2 , high white cell count, anaemia, low albumin, current smoking, history of cancer, history of myocardial infarction, history of congestive heart failure, depressive symptoms and ADL and IADL disability and impaired chair stands. We found that overweight and obesity and/or being a lifelong nondrinker of alcohol were protective against mortality. Compared to men with less than or equal to one risk factor, the hazard ratio in men with three risk factors was 2.5; with four risk factors, it was 4.0; with five risk factors, it was 4.9; and for six or more risk factors, it AGE (2014) was 11.4, respectively. We have identified common risk factors that predict mortality that may be useful in making clinical decisions among older people living in the community. Our findings suggest that, in primary care, screening and management of multiple risk factors are important to consider for extending survival, rather than simply considering individual risk factors in isolation. Some of the "traditional" risk factors for mortality in a younger population, including high blood pressure, hypercholesterolaemia, overweight and obesity and diabetes, were not independent predictors of mortality in this population of older men.

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“…This links social-science to an epidemiological and physiological literature represented by work such as Crimmins et al (2008), Edmunds (1982) However, a straightforwardly relevant question to ask is whether subjective responses on people"s feelings of psychological well-being are reliable. Krueger and Schkade (2008), who argue in the affirmative, show that people"s own satisfaction answers through time are correlated with a Pearson"s r of approximately 0.6.…”

Section: Perhaps Of Particular Interest To Industrial Relations Reseamentioning

confidence: 99%

Emotional Prosperity and the Stiglitz Commission

Oswald

2010

Brit J Industrial Rel

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This paper argues --in line with the proposals of the recent Stiglitz Commission on the Measurement of Economic Performance and Social Progress --that we should now be measuring a nation"s emotional prosperity rather than its economic prosperity (that is, we ought to focus on the level of mental well-being not the number of pounds in people"s bank accounts). The paper reviews recent ideas in this field. It also describes seven recent studies that, worryingly, suggest that emotional prosperity may be declining through time. For labourmarket specialists, a key question for future research is how much this downward trend can be traced back to increased pressures in working life. That question currently remains open.

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Chapter 5 Biomarkers Related To Aging In Human Populations

Cited by 137 publications

References 359 publications

Anorexia, undernutrition, weight loss, sarcopenia, and cachexia of aging

Anorexia, undernutrition, weight loss, sarcopenia, and cachexia of aging

Multiple, but not traditional risk factors predict mortality in older people: the concord health and ageing in men project

Emotional Prosperity and the Stiglitz Commission

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