Chapter 4 The Pyridine Alkaloids

Marion, Léo

doi:10.1016/s1876-0813(08)60173-6

Cited by 3 publications

(2 citation statements)

References 342 publications

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“…The number of alkaloids present in a species seems to increase with plant maturity (Lopez et al 1994). In contrast to L. infl ata, L. siphilitica and probably L. berlandieri contain pyridines other than lobeline (Marion 1960;Williams et al 1987). In contrast to L. infl ata, L. siphilitica and probably L. berlandieri contain pyridines other than lobeline (Marion 1960;Williams et al 1987).…”

Section: Disease Genesis-an Array Of Pyridine Alkaloids Some-mentioning

confidence: 91%

Campanulaceae Juss.

2012

Toxic Plants of North America

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Section: Disease Genesis-an Array Of Pyridine Alkaloids Some-mentioning

confidence: 91%

Campanulaceae Juss.

2012

Toxic Plants of North America

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“…S(2)-nicotine is the natural enantiomer in tobacco [Marion, 1950], although racemization to R(1)-nicotine occurs to a small extent during combustion [Zevin et al, 1998]. The pharmacological and physiological properties of nicotine have been extensively studied in the last decades, including its binding sites and action in the nervous system [for review see Aceto and Martin, 1982;Domino, 1998;Rand, 1989;Zevin et al, 1998].…”

Section: Introductionmentioning

confidence: 99%

Activation of olfactory and trigeminal cortical areas following stimulation of the nasal mucosa with low concentrations of S(−)‐nicotine vapor—An fMRI study on chemosensory perception

Albrecht¹,

Kopietz²,

Linn³

et al. 2008

Human Brain Mapping

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Applied to the nasal mucosa in low concentrations, nicotine vapor evokes odorous sensations (mediated by the olfactory system) whereas at higher concentrations nicotine vapor additionally produces burning and stinging sensations in the nose (mediated by the trigeminal system). The objective of this study was to determine whether intranasal stimulation with suprathreshold concentrations of S(-)-nicotine vapor causes brain activation in olfactory cortical areas or if trigeminal cortical areas are also activated. Individual olfactory detection thresholds for S(-)-nicotine were determined in 19 healthy occasional smokers using a computer-controlled air-dilution olfactometer. Functional magnetic resonance images were acquired using a 1.5T MR scanner with applications of nicotine in concentrations at or just above the individual's olfactory detection threshold. Subjects reliably perceived the stimuli as being odorous. Accordingly, activation of brain areas known to be involved in processing of olfactory stimuli was identified. Although most of the subjects never or only rarely observed a burning or painful sensation in the nose, brain areas associated with the processing of painful stimuli were activated in all subjects. This indicates that the olfactory and trigeminal systems are activated during perception of nicotine and it is not possible to completely separate olfactory from trigeminal effects by lowering the concentration of the applied nicotine. In conclusion, even at low concentrations that do not consistently lead to painful sensations, intranasally applied nicotine activates both the olfactory and the trigeminal system.

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Insect Hormones and Insect Chemical Ecology

Morgan

Wilson

1999

Comprehensive Natural Products Chemistry

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Chapter 4 The Pyridine Alkaloids

Cited by 3 publications

References 342 publications

Campanulaceae Juss.

Campanulaceae Juss.

Activation of olfactory and trigeminal cortical areas following stimulation of the nasal mucosa with low concentrations of S(−)‐nicotine vapor—An fMRI study on chemosensory perception

Insect Hormones and Insect Chemical Ecology

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