Chapter 28 The thalamic contribution to the emergence of the readiness potential

Brunia, C.H.M.; Bosch, Dirk; Speelman, Johannes D.; Berg-Lenssen, M.M.C. van den; Boxtel, G.J.M. van

doi:10.1016/s1567-424x(09)70159-x

Cited by 5 publications

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“…A similar negative peak also appeared for the imagined movement task ϳ200 -300 ms after target onset. This negative deflection in cortical signals was also observed in previous EEG and MEG studies, and it has been suggested that this waveform is related to the readiness potential, which might be modulated by movement direction (Brunia et al 2000;Kornhuber and Deecke 1965;Waldert et al 2008). …”

Section: R E S U L T Ssupporting

confidence: 78%

Decoding and Cortical Source Localization for Intended Movement Direction With MEG

Wang

Sudre

et al. 2010

Journal of Neurophysiology

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Wang W, Sudre GP, Xu Y, Kass RE, Collinger JL, Degenhart AD, Bagic AI, Weber DJ. Decoding and cortical source localization for intended movement direction with MEG. J Neurophysiol 104: 2451-2461. First published August 25, 2010 doi:10.1152/jn.00239.2010. Magnetoencephalography (MEG) enables a noninvasive interface with the brain that is potentially capable of providing movement-related information similar to that obtained using more invasive neural recording techniques. Previous studies have shown that movement direction can be decoded from multichannel MEG signals recorded in humans performing wrist movements. We studied whether this information can be extracted without overt movement of the subject, because the targeted users of brain-controlled interface (BCI) technology are those with severe motor disabilities. The objectives of this study were twofold: 1) to decode intended movement direction from MEG signals recorded during the planning period before movement onset and during imagined movement and 2) to localize cortical sources modulated by intended movement direction. Ten able-bodied subjects performed both overt and imagined wrist movement while their cortical activities were recorded using a whole head MEG system. The intended movement direction was decoded using linear discriminant analysis and a Bayesian classifier. Minimum current estimation (MCE) in combination with a bootstrapping procedure enabled source-space statistical analysis, which showed that the contralateral motor cortical area was significantly modulated by intended movement direction, and this modulation was the strongest ϳ100 ms before the onset of overt movement. These results suggest that it is possible to study cortical representation of specific movement information using MEG, and such studies may aid in presurgical localization of optimal sites for implanting electrodes for BCI systems.

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Section: R E S U L T Ssupporting

confidence: 78%

Decoding and Cortical Source Localization for Intended Movement Direction With MEG

Wang

Sudre

et al. 2010

Journal of Neurophysiology

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“…Paradiso, Cunic, and Chen have used this opportunity to record the RP from either the Vim or the STN. This is a very valuable contribution, because it shows that, as expected (Brunia et al, 2000), an RP is present in both subcortical nuclei. Even more important is their finding that in most patients a bilateral subcortical RP precedes a unilateral simple movement.…”

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confidence: 76%

Slow Potentials in Anticipatory Behavior

Brunia

2004

Journal of Psychophysiology

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“…Previous studies suggested that cortical RPs are the expression of concerted activity in a number of cortical and subcortical brain structures, and that the thalamus plays an important role in premovement processing (Brunia, 1999; Brunia & van Boxtel, 2001). A study in patients with thalamic electrodes used for treatment of tremor showed enhanced cortical RPs when the stimulator was switched on compared to when the stimulator was switched off, suggesting that thalamic stimulation activates the processes that cause the emergence of the RP (Brunia et al, 2000). Our results are consistent with this hypothesis and suggest that thalamic DBS does not simply work by inhibiting the target area.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Subcortical Structures in the Preparation of Self-Paced Movement

Paradiso

Cunic²,

Chen

2004

Journal of Psychophysiology

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Although it has long been suggested that the basal ganglia and thalamus are involved in movement planning and preparation, there was little direct evidence in humans to support this hypothesis. Deep brain stimulation (DBS) is a well-established treatment for movement disorders such as Parkinson's disease, tremor, and dystonia. In patients undergoing DBS surgery, we recorded simultaneously from scalp contacts and from electrodes surgically implanted in the subthalamic nucleus (STN) of 13 patients with Parkinson's disease and in the “cerebellar” thalamus of 5 patients with tremor. The aim of our studies was to assess the role of the cortico-basal ganglia-thalamocortical loop through the STN and the cerebello-thalamocortical circuit through the “cerebellar” thalamus in movement preparation. The patients were asked to perform self-paced wrist extension movements. All subjects showed a cortical readiness potential (RP) with onset ranging between 1.5 to 2s before the onset of movement. Subcortical RPs were recorded in 11 of 13 with electrodes in the STN and in 4 of 5 patients with electrodes in the thalamus. The onset time of the STN and thalamic RPs were not significantly different from the onset time of the scalp RP. The STN and thalamic RPs were present before both contralateral and ipsilateral hand movements. Postoperative MRI studies showed that contacts with maximum RP amplitude generally were inside the target nucleus. These findings indicate that both the basal ganglia and the cerebellar circuits participate in movement preparation in parallel with the cortex.

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Chapter 28 The thalamic contribution to the emergence of the readiness potential

Cited by 5 publications

References 1 publication

Decoding and Cortical Source Localization for Intended Movement Direction With MEG

Decoding and Cortical Source Localization for Intended Movement Direction With MEG

Slow Potentials in Anticipatory Behavior

Involvement of Subcortical Structures in the Preparation of Self-Paced Movement

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