Chapter 20. Pharmacologic Regulation of Serum Lipoproteins

Day, Charles

doi:10.1016/s0065-7743(08)60623-5

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“…Japanese quail (Coturnix coturnix japonica) have been used extensively as a model for the study of atheroslcerosis Donaldson, 1977a,b, 1979;Day, 1978;Day and Stafford, 1975;Day et al, 1977Day et al, , 1979Chapman et al, 1976;Soret et al, 1976). Morrissey and Donaldson (1977a) used a semipurified diet containing cholesterol to induce hypercholesteremia and atherosclerosis in Japanese quail within a short period of time.…”

Section: Introductionmentioning

confidence: 99%

Effect of Cholesterol Feeding on Serum Lipoproteins and Atherosclerosis in Atherosclerosis-Susceptible and Atherosclerosis-Resistant Japanese Quail

Donaldson

1982

Poultry Science

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Male and female Japanese quail from two strains bred for differing susceptibility to induction of atherosclerosis by dietary cholesterol (RES = resistant, SUS = susceptible) were fed a control diet or control diet + .5% USP cholesterol. The diets were fed for 20 weeks beginning when the quail were 7 weeks old. Only quail fed cholesterol developed atherosclerosis. Atherosclerosis (incidence and severity) was higher in males than females and higher in SUS than RES. Cholesterol feeding increased aortic, liver, and serum cholesterol concentrations and liver total fat content. There were high positive correlations between serum cholesterol and liver cholesterol in all cholesterol-fed groups but not in control groups. Diet, sex, and strain differences in cholesterol distribution among the various serum lipoproteins and ratios of beta/alpha lipoproteins were observed. These differences are discussed in terms of their usefulness in predicting atherosclerosis in quail as compared with humans.

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Section: Introductionmentioning

confidence: 99%

Effect of Cholesterol Feeding on Serum Lipoproteins and Atherosclerosis in Atherosclerosis-Susceptible and Atherosclerosis-Resistant Japanese Quail

Donaldson

1982

Poultry Science

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Chapter 20. Pharmacologic Regulation of Serum Lipoproteins

Cited by 1 publication

References 32 publications

Effect of Cholesterol Feeding on Serum Lipoproteins and Atherosclerosis in Atherosclerosis-Susceptible and Atherosclerosis-Resistant Japanese Quail

Effect of Cholesterol Feeding on Serum Lipoproteins and Atherosclerosis in Atherosclerosis-Susceptible and Atherosclerosis-Resistant Japanese Quail

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