CHAPTER 2. Carbon–Carbon Bond Forming by Ball Milling

Jacob, Katharina; Schmidt, Robert R.; Stolle, Achim

doi:10.1039/9781782621980-00034

Cited by 2 publications

(3 citation statements)

References 51 publications

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“…Due to several advantages, the area mechanochemistry has received significant attention over solution-based chemical methods and process developments [ 12 , 27 , 29 ]. The mechanochemical formation of carbon–carbon [ 39 – 40 ], carbon–heteroatom [ 41 – 42 ], metal–ligand coordination bonds [ 43 ], non-covalent interactions such as hydrogen bonds or π–π arene stacking interactions [ 44 ], etc. are popularly known in literature.…”

Section: Introductionmentioning

confidence: 99%

Mechanochemical synthesis of small organic molecules

Achar

Bose

Mal

2017

Beilstein J. Org. Chem.

231

111

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With the growing interest in renewable energy and global warming, it is important to minimize the usage of hazardous chemicals in both academic and industrial research, elimination of waste, and possibly recycle them to obtain better results in greener fashion. The studies under the area of mechanochemistry which cover the grinding chemistry to ball milling, sonication, etc. are certainly of interest to the researchers working on the development of green methodologies. In this review, a collection of examples on recent developments in organic bond formation reactions like carbon–carbon (C–C), carbon–nitrogen (C–N), carbon–oxygen (C–O), carbon–halogen (C–X), etc. is documented. Mechanochemical syntheses of heterocyclic rings, multicomponent reactions and organometallic molecules including their catalytic applications are also highlighted.

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Section: Introductionmentioning

confidence: 99%

Mechanochemical synthesis of small organic molecules

Achar

Bose

Mal

2017

Beilstein J. Org. Chem.

231

111

View full text Add to dashboard Cite

show abstract

“…[92][93][94][95][96][97][98][99][100][101] In recent years, solvent-free mechanochemistry has emerged as a 'green' alternative to the unsustainable use of petroleum-based solvents in classic organic chemistry transformations. [102][103][104][105][106] With respect to ne chemical manufacturing, it is also an effective experimental procedure, known as medicinal mechanochemistry, for the synthesis of many classes of organic compounds, active pharmaceutical ingredients (APIs), and commercially-available drugs. 75,89,[105][106][107][108][109][110][111][112][113] Unlike solution-phase organic chemistry, solvent-free ball milling conditions are generally conducted without the need for inert gas, external heat, or solvent.…”

Section: Introductionmentioning

confidence: 99%

“…[102][103][104][105][106] With respect to ne chemical manufacturing, it is also an effective experimental procedure, known as medicinal mechanochemistry, for the synthesis of many classes of organic compounds, active pharmaceutical ingredients (APIs), and commercially-available drugs. 75,89,[105][106][107][108][109][110][111][112][113] Unlike solution-phase organic chemistry, solvent-free ball milling conditions are generally conducted without the need for inert gas, external heat, or solvent. The stainless-steel reactors vials are machined from stainless-steel rods and the organic/ inorganic reactants are added in the open atmosphere with one or more stainless-steel balls.…”

Section: Introductionmentioning

confidence: 99%