Chapter 16. Nonclassical Targets for Antibacterial Agents

The search for antimicrobial agents effective against bacteria resistant to multiple antibiotics

“…In the search for new microbial targets, a number of other processes that would affect bacterial growth have been suggested. These include inhibition of lipoprotein and lipopolysaccharide biosynthesis in gram-negative bacteria, cell division, and metabolite transport (1,59). Many of these pathways have been validated as candidate targets for antibiotic action by showing that mutations in the structural genes encoding the pathways are lethal (59).…”