Chapter 15. Sc, Y, the lanthanides, and the actinides

Jones, Catherine

doi:10.1039/ic9918800211

Cited by 3 publications

(1 citation statement)

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“…Among invertebrates, OCT influences foraging behavior in honey bees (17); resets aggressive motivation in crickets (18); and functions in appetitive associative learning (19,20), ethanol tolerance development (21), ovarian muscle contraction (22), and possibly aggression levels in Drosophila (23). Like their vertebrate amine neuron counterparts (24)(25)(26), OCT neurons in Drosophila (i) are few in number but have enormous fields of innervation covering essentially all neuropil areas in the fly brain (27)(28)(29) and (ii) function by activating multiple G protein-coupled receptors (30,31).…”

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confidence: 99%

Modulation of Drosophila male behavioral choice

Certel

Savella

Schlegel

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

142

163

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The reproductive and defensive behaviors that are initiated in response to specific sensory cues can provide insight into how choices are made between different social behaviors. We manipulated both the activity and sex of a subset of neurons and found significant changes in male social behavior. Results from aggression assays indicate that the neuromodulator octopamine (OCT) is necessary for Drosophila males to coordinate sensory cue information presented by a second male and respond with the appropriate behavior: aggression rather than courtship. In competitive male courtship assays, males with no OCT or with low OCT levels do not adapt to changing sensory cues and court both males and females. We identified a small subset of neurons in the suboesophageal ganglion region of the adult male brain that coexpress OCT and male forms of the neural sex determination factor, Fruitless (Fru M ). A single Fru M -positive OCT neuron sends extensive bilateral arborizations to the suboesophageal ganglion, the lateral accessory lobe, and possibly the posterior antennal lobe, suggesting a mechanism for integrating multiple sensory modalities. Furthermore, eliminating the expression of Fru M by transformer expression in OCT/tyramine neurons changes the aggression versus courtship response behavior. These results provide insight into how complex social behaviors are coordinated in the nervous system and suggest a role for neuromodulators in the functioning of male-specific circuitry relating to behavioral choice.aggression ͉ courtship ͉ fruitless ͉ octopamine ͉ sex-specific

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